New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

Alexander W. Pfaff, Alejandra de-la-Torre, Elise Rochet, Julie Brunet, Marcela Sabou, Arnaud Sauer, Tristan Bourcier, Jorge E. Gomez-Marin, Ermanno Candolfi

Resultado de la investigación: Contribución a RevistaRevisión Literaria

27 Citas (Scopus)

Resumen

Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America.
Idioma originalEnglish (US)
Páginas (desde-hasta)99-107
Número de páginas9
PublicaciónInternational Journal for Parasitology
DOI
EstadoPublished - feb 1 2014

Huella dactilar

Ocular Toxoplasmosis
Parasites
South America
Toxoplasma
Eye Manifestations
Protozoan Infections
Parasite Load
Communicable Disease Control
Tropism
Interleukin-17
Toxoplasmosis
Immunologic Factors
North America
Genetic Markers
Pathology

Citar esto

Pfaff, Alexander W. ; de-la-Torre, Alejandra ; Rochet, Elise ; Brunet, Julie ; Sabou, Marcela ; Sauer, Arnaud ; Bourcier, Tristan ; Gomez-Marin, Jorge E. ; Candolfi, Ermanno. / New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. En: International Journal for Parasitology. 2014 ; pp. 99-107.
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abstract = "Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2{\%} of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America.",
author = "Pfaff, {Alexander W.} and Alejandra de-la-Torre and Elise Rochet and Julie Brunet and Marcela Sabou and Arnaud Sauer and Tristan Bourcier and Gomez-Marin, {Jorge E.} and Ermanno Candolfi",
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New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. / Pfaff, Alexander W.; de-la-Torre, Alejandra; Rochet, Elise; Brunet, Julie; Sabou, Marcela; Sauer, Arnaud; Bourcier, Tristan; Gomez-Marin, Jorge E.; Candolfi, Ermanno.

En: International Journal for Parasitology, 01.02.2014, p. 99-107.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

AU - Pfaff, Alexander W.

AU - de-la-Torre, Alejandra

AU - Rochet, Elise

AU - Brunet, Julie

AU - Sabou, Marcela

AU - Sauer, Arnaud

AU - Bourcier, Tristan

AU - Gomez-Marin, Jorge E.

AU - Candolfi, Ermanno

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America.

AB - Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America.

U2 - 10.1016/j.ijpara.2013.09.007

DO - 10.1016/j.ijpara.2013.09.007

M3 - Literature review

SP - 99

EP - 107

JO - International Journal for Parasitology

JF - International Journal for Parasitology

SN - 0020-7519

ER -