Neighboring gene regulation by antisense long Non-Coding RNAs

Victoria E. Villegas, Peter G. Zaphiropoulos

Resultado de la investigación: Contribución a RevistaRevisión Literaria

99 Citas (Scopus)

Resumen

© 2015 by the authors; licensee MDPI, Basel, Switzerland.Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm.
Idioma originalEnglish (US)
Páginas (desde-hasta)3251-3266
Número de páginas16
PublicaciónInternational Journal of Molecular Sciences
DOI
EstadoPublished - feb 3 2015

Huella dactilar

Long Noncoding RNA
Antisense RNA
gene expression
RNA
Gene expression
Genes
proteins
chromatin
cytoplasm
nucleic acids
Biological Phenomena
Switzerland
Chromatin Assembly and Disassembly
Gene Expression Regulation
Cellular Structures
Transcription
deoxyribonucleic acid
Transcriptome
Nucleic Acids
Chromatin

Citar esto

@article{71cfff30258b4cfea9177dbb0f912204,
title = "Neighboring gene regulation by antisense long Non-Coding RNAs",
abstract = "{\circledC} 2015 by the authors; licensee MDPI, Basel, Switzerland.Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm.",
author = "Villegas, {Victoria E.} and Zaphiropoulos, {Peter G.}",
year = "2015",
month = "2",
day = "3",
doi = "10.3390/ijms16023251",
language = "English (US)",
pages = "3251--3266",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

}

Neighboring gene regulation by antisense long Non-Coding RNAs. / Villegas, Victoria E.; Zaphiropoulos, Peter G.

En: International Journal of Molecular Sciences, 03.02.2015, p. 3251-3266.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Neighboring gene regulation by antisense long Non-Coding RNAs

AU - Villegas, Victoria E.

AU - Zaphiropoulos, Peter G.

PY - 2015/2/3

Y1 - 2015/2/3

N2 - © 2015 by the authors; licensee MDPI, Basel, Switzerland.Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm.

AB - © 2015 by the authors; licensee MDPI, Basel, Switzerland.Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can generate long non-coding RNAs (lncRNAs), one of the most diverse classes of cellular transcripts, which have demonstrated multifunctional roles in fundamental biological processes, including embryonic pluripotency, differentiation and development. Antisense lncRNAs have been shown to control nearly every level of gene regulation—pretranscriptional, transcriptional and posttranscriptional—through DNA–RNA, RNA–RNA or protein–RNA interactions. This review is centered on functional studies of antisense lncRNA-mediated regulation of neighboring gene expression. Specifically, it addresses how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes by altering the sense mRNA structure or the cellular compartmental distribution, either in the nucleus or the cytoplasm.

U2 - 10.3390/ijms16023251

DO - 10.3390/ijms16023251

M3 - Literature review

SP - 3251

EP - 3266

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

ER -