Natural selection and genetic diversity in the butterfly heliconius melpomene

Simon H. Martin, Markus Möst, William J. Palmer, Camilo Salazar, W. Owen McMillan, Francis M. Jiggins, Chris D. Jiggins

Resultado de la investigación: Contribución a RevistaArtículo

18 Citas (Scopus)

Resumen

© 2016 by the Genetics Society of America.A combination of selective and neutral evolutionary forces shape patterns of genetic diversity in nature. Among the insects, most previous analyses of the roles of drift and selection in shaping variation across the genome have focused on the genus Drosophila. A more complete understanding of these forces will come from analyzing other taxa that differ in population demography and other aspects of biology. We have analyzed diversity and signatures of selection in the neotropical Heliconius butterflies using resequenced genomes from 58 wild-caught individuals of Heliconius melpomene and another 21 resequenced genomes representing 11 related species. By comparing intraspecific diversity and interspecific divergence, we estimate that 31% of amino acid substitutions between Heliconius species are adaptive. Diversity at putatively neutral sites is negatively correlated with the local density of coding sites as well as nonsynonymous substitutions and positively correlated with recombination rate, indicating widespread linked selection. This process also manifests in significantly reduced diversity on longer chromosomes, consistent with lower recombination rates. Although hitchhiking around beneficial nonsynonymous mutations has significantly shaped genetic variation in H. melpomene, evidence for strong selective sweeps is limited overall. We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation. On the whole, our study suggests that positive selection is less pervasive in these butterflies as compared to fruit flies, a fact that curiously results in very similar levels of neutral diversity in these very different insects.
Idioma originalEnglish (US)
Páginas (desde-hasta)525-541
Número de páginas17
PublicaciónGenetics
DOI
EstadoPublished - may 1 2016

Huella dactilar

Butterflies
Genetic Selection
Genome
Genetic Recombination
Insects
Population
Amino Acid Substitution
Diptera
Haplotypes
Drosophila
Fruit
Chromosomes
Demography
Mutation

Citar esto

Martin, S. H., Möst, M., Palmer, W. J., Salazar, C., McMillan, W. O., Jiggins, F. M., & Jiggins, C. D. (2016). Natural selection and genetic diversity in the butterfly heliconius melpomene. Genetics, 525-541. https://doi.org/10.1534/genetics.115.183285
Martin, Simon H. ; Möst, Markus ; Palmer, William J. ; Salazar, Camilo ; McMillan, W. Owen ; Jiggins, Francis M. ; Jiggins, Chris D. / Natural selection and genetic diversity in the butterfly heliconius melpomene. En: Genetics. 2016 ; pp. 525-541.
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abstract = "{\circledC} 2016 by the Genetics Society of America.A combination of selective and neutral evolutionary forces shape patterns of genetic diversity in nature. Among the insects, most previous analyses of the roles of drift and selection in shaping variation across the genome have focused on the genus Drosophila. A more complete understanding of these forces will come from analyzing other taxa that differ in population demography and other aspects of biology. We have analyzed diversity and signatures of selection in the neotropical Heliconius butterflies using resequenced genomes from 58 wild-caught individuals of Heliconius melpomene and another 21 resequenced genomes representing 11 related species. By comparing intraspecific diversity and interspecific divergence, we estimate that 31{\%} of amino acid substitutions between Heliconius species are adaptive. Diversity at putatively neutral sites is negatively correlated with the local density of coding sites as well as nonsynonymous substitutions and positively correlated with recombination rate, indicating widespread linked selection. This process also manifests in significantly reduced diversity on longer chromosomes, consistent with lower recombination rates. Although hitchhiking around beneficial nonsynonymous mutations has significantly shaped genetic variation in H. melpomene, evidence for strong selective sweeps is limited overall. We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation. On the whole, our study suggests that positive selection is less pervasive in these butterflies as compared to fruit flies, a fact that curiously results in very similar levels of neutral diversity in these very different insects.",
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Martin, SH, Möst, M, Palmer, WJ, Salazar, C, McMillan, WO, Jiggins, FM & Jiggins, CD 2016, 'Natural selection and genetic diversity in the butterfly heliconius melpomene', Genetics, pp. 525-541. https://doi.org/10.1534/genetics.115.183285

Natural selection and genetic diversity in the butterfly heliconius melpomene. / Martin, Simon H.; Möst, Markus; Palmer, William J.; Salazar, Camilo; McMillan, W. Owen; Jiggins, Francis M.; Jiggins, Chris D.

En: Genetics, 01.05.2016, p. 525-541.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - Natural selection and genetic diversity in the butterfly heliconius melpomene

AU - Martin, Simon H.

AU - Möst, Markus

AU - Palmer, William J.

AU - Salazar, Camilo

AU - McMillan, W. Owen

AU - Jiggins, Francis M.

AU - Jiggins, Chris D.

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N2 - © 2016 by the Genetics Society of America.A combination of selective and neutral evolutionary forces shape patterns of genetic diversity in nature. Among the insects, most previous analyses of the roles of drift and selection in shaping variation across the genome have focused on the genus Drosophila. A more complete understanding of these forces will come from analyzing other taxa that differ in population demography and other aspects of biology. We have analyzed diversity and signatures of selection in the neotropical Heliconius butterflies using resequenced genomes from 58 wild-caught individuals of Heliconius melpomene and another 21 resequenced genomes representing 11 related species. By comparing intraspecific diversity and interspecific divergence, we estimate that 31% of amino acid substitutions between Heliconius species are adaptive. Diversity at putatively neutral sites is negatively correlated with the local density of coding sites as well as nonsynonymous substitutions and positively correlated with recombination rate, indicating widespread linked selection. This process also manifests in significantly reduced diversity on longer chromosomes, consistent with lower recombination rates. Although hitchhiking around beneficial nonsynonymous mutations has significantly shaped genetic variation in H. melpomene, evidence for strong selective sweeps is limited overall. We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation. On the whole, our study suggests that positive selection is less pervasive in these butterflies as compared to fruit flies, a fact that curiously results in very similar levels of neutral diversity in these very different insects.

AB - © 2016 by the Genetics Society of America.A combination of selective and neutral evolutionary forces shape patterns of genetic diversity in nature. Among the insects, most previous analyses of the roles of drift and selection in shaping variation across the genome have focused on the genus Drosophila. A more complete understanding of these forces will come from analyzing other taxa that differ in population demography and other aspects of biology. We have analyzed diversity and signatures of selection in the neotropical Heliconius butterflies using resequenced genomes from 58 wild-caught individuals of Heliconius melpomene and another 21 resequenced genomes representing 11 related species. By comparing intraspecific diversity and interspecific divergence, we estimate that 31% of amino acid substitutions between Heliconius species are adaptive. Diversity at putatively neutral sites is negatively correlated with the local density of coding sites as well as nonsynonymous substitutions and positively correlated with recombination rate, indicating widespread linked selection. This process also manifests in significantly reduced diversity on longer chromosomes, consistent with lower recombination rates. Although hitchhiking around beneficial nonsynonymous mutations has significantly shaped genetic variation in H. melpomene, evidence for strong selective sweeps is limited overall. We did however identify two regions where distinct haplotypes have swept in different populations, leading to increased population differentiation. On the whole, our study suggests that positive selection is less pervasive in these butterflies as compared to fruit flies, a fact that curiously results in very similar levels of neutral diversity in these very different insects.

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DO - 10.1534/genetics.115.183285

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EP - 541

JO - Genetics

JF - Genetics

SN - 0016-6731

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