Nanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrier

Martha Leonor Pinzón-Daza, Ivana Campia, Joanna Kopecka, Ruth Garzón, Dario Ghigo, Chiara Riganti

Resultado de la investigación: Contribución a RevistaArtículo de revisión

45 Citas (Scopus)

Resumen

The blood-brain barrier (BBB), the unusual microvascular endothelial interface between the central nervous system (CNS) and the circulatory system, is a major hindrance to drug delivery in the brain parenchyma. Besides the absence of fenestrations and the abundance of tight junctions, ATP-binding cassette (ABC) transporters critically reduce drug entry within the CNS, as they carry many drugs back into the bloodstream. Nanoparticle-and liposome-carried drugs, because of their increased cellular uptake and reduced efflux through ABC transporters, have been developed in recent times to circumvent the low drug permeability of the BBB. This review discusses the role of ABC transporters in controlling drug penetration into the brain parenchyma, the rationale for using nanoparticle-and liposome-based strategies to increase drug delivery across the BBB and new therapeutic strategies for using nanoparticle-and liposome-carried drugs in different conditions, ranging from CNS tumors and neurodegenerative diseases to viral infections and epilepsy. © 2013 Bentham Science Publishers.
Idioma originalEnglish (US)
Páginas (desde-hasta)625-640
Número de páginas16
PublicaciónCurrent Drug Metabolism
DOI
EstadoPublished - jul 1 2013

Huella dactilar

Drug Delivery Systems
Blood-Brain Barrier
Drug delivery
Liposomes
Nanoparticles
ATP-Binding Cassette Transporters
Neurology
Pharmaceutical Preparations
Brain
Neurodegenerative diseases
Central Nervous System
Central Nervous System Neoplasms
Tumors
Tight Junctions
Central Nervous System Diseases
Virus Diseases
Cardiovascular System
Neurodegenerative Diseases
Permeability
Epilepsy

Citar esto

Pinzón-Daza, Martha Leonor ; Campia, Ivana ; Kopecka, Joanna ; Garzón, Ruth ; Ghigo, Dario ; Riganti, Chiara. / Nanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrier. En: Current Drug Metabolism. 2013 ; pp. 625-640.
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Nanoparticle-and liposome-carried drugs: New strategies for active targeting and drug delivery across blood-brain barrier. / Pinzón-Daza, Martha Leonor; Campia, Ivana; Kopecka, Joanna; Garzón, Ruth; Ghigo, Dario; Riganti, Chiara.

En: Current Drug Metabolism, 01.07.2013, p. 625-640.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

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AU - Pinzón-Daza, Martha Leonor

AU - Campia, Ivana

AU - Kopecka, Joanna

AU - Garzón, Ruth

AU - Ghigo, Dario

AU - Riganti, Chiara

PY - 2013/7/1

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AB - The blood-brain barrier (BBB), the unusual microvascular endothelial interface between the central nervous system (CNS) and the circulatory system, is a major hindrance to drug delivery in the brain parenchyma. Besides the absence of fenestrations and the abundance of tight junctions, ATP-binding cassette (ABC) transporters critically reduce drug entry within the CNS, as they carry many drugs back into the bloodstream. Nanoparticle-and liposome-carried drugs, because of their increased cellular uptake and reduced efflux through ABC transporters, have been developed in recent times to circumvent the low drug permeability of the BBB. This review discusses the role of ABC transporters in controlling drug penetration into the brain parenchyma, the rationale for using nanoparticle-and liposome-based strategies to increase drug delivery across the BBB and new therapeutic strategies for using nanoparticle-and liposome-carried drugs in different conditions, ranging from CNS tumors and neurodegenerative diseases to viral infections and epilepsy. © 2013 Bentham Science Publishers.

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