Naloxone facilitates appetitive extinction and eliminates escape from frustration

Jacob N. Norris, Andrés M. Pérez-Acosta, Leonardo A. Ortega, Mauricio R. Papini

Resultado de la investigación: Contribución a RevistaArtículo

18 Citas (Scopus)

Resumen

Two experiments tested the effects of opioid receptor blockage on behavior. In Experiment 1, rats reinforced for lever pressing with either sucrose or food pellets received treatment with saline, 2, and 10 mg/kg naloxone, i.p. (within-subject design). Naloxone 10 mg/kg increased response latency, but 2 mg/kg had no effect. When shifted to extinction (between-group design), naloxone (2 and 10 mg/kg) facilitated extinction relative to saline animals, after reinforcement with either sucrose or food pellets. In Experiment 2, after 10 sessions of access to 32% sucrose or an empty tube (between-group design), all rats were exposed to the empty tube while allowing them to jump over a barrier into a different compartment. Escape latencies were shorter for downshifted saline than for saline rats always given access to the empty tube. This escape-from-frustration effect was eliminated by naloxone (2 mg/kg, i.p.). Opioid blockage appears to reduce the value of alternative incentives. © 2009 Elsevier Inc. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)81-87
Número de páginas7
PublicaciónPharmacology Biochemistry and Behavior
DOI
EstadoPublished - nov 1 2009

Huella dactilar

Frustration
Naloxone
Sucrose
Rats
Food
Experiments
Opioid Receptors
Opioid Analgesics
Reaction Time
Motivation
Reinforcement
Animals
Psychological Extinction
Therapeutics

Citar esto

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title = "Naloxone facilitates appetitive extinction and eliminates escape from frustration",
abstract = "Two experiments tested the effects of opioid receptor blockage on behavior. In Experiment 1, rats reinforced for lever pressing with either sucrose or food pellets received treatment with saline, 2, and 10 mg/kg naloxone, i.p. (within-subject design). Naloxone 10 mg/kg increased response latency, but 2 mg/kg had no effect. When shifted to extinction (between-group design), naloxone (2 and 10 mg/kg) facilitated extinction relative to saline animals, after reinforcement with either sucrose or food pellets. In Experiment 2, after 10 sessions of access to 32{\%} sucrose or an empty tube (between-group design), all rats were exposed to the empty tube while allowing them to jump over a barrier into a different compartment. Escape latencies were shorter for downshifted saline than for saline rats always given access to the empty tube. This escape-from-frustration effect was eliminated by naloxone (2 mg/kg, i.p.). Opioid blockage appears to reduce the value of alternative incentives. {\circledC} 2009 Elsevier Inc. All rights reserved.",
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Naloxone facilitates appetitive extinction and eliminates escape from frustration. / Norris, Jacob N.; Pérez-Acosta, Andrés M.; Ortega, Leonardo A.; Papini, Mauricio R.

En: Pharmacology Biochemistry and Behavior, 01.11.2009, p. 81-87.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Naloxone facilitates appetitive extinction and eliminates escape from frustration

AU - Norris, Jacob N.

AU - Pérez-Acosta, Andrés M.

AU - Ortega, Leonardo A.

AU - Papini, Mauricio R.

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Two experiments tested the effects of opioid receptor blockage on behavior. In Experiment 1, rats reinforced for lever pressing with either sucrose or food pellets received treatment with saline, 2, and 10 mg/kg naloxone, i.p. (within-subject design). Naloxone 10 mg/kg increased response latency, but 2 mg/kg had no effect. When shifted to extinction (between-group design), naloxone (2 and 10 mg/kg) facilitated extinction relative to saline animals, after reinforcement with either sucrose or food pellets. In Experiment 2, after 10 sessions of access to 32% sucrose or an empty tube (between-group design), all rats were exposed to the empty tube while allowing them to jump over a barrier into a different compartment. Escape latencies were shorter for downshifted saline than for saline rats always given access to the empty tube. This escape-from-frustration effect was eliminated by naloxone (2 mg/kg, i.p.). Opioid blockage appears to reduce the value of alternative incentives. © 2009 Elsevier Inc. All rights reserved.

AB - Two experiments tested the effects of opioid receptor blockage on behavior. In Experiment 1, rats reinforced for lever pressing with either sucrose or food pellets received treatment with saline, 2, and 10 mg/kg naloxone, i.p. (within-subject design). Naloxone 10 mg/kg increased response latency, but 2 mg/kg had no effect. When shifted to extinction (between-group design), naloxone (2 and 10 mg/kg) facilitated extinction relative to saline animals, after reinforcement with either sucrose or food pellets. In Experiment 2, after 10 sessions of access to 32% sucrose or an empty tube (between-group design), all rats were exposed to the empty tube while allowing them to jump over a barrier into a different compartment. Escape latencies were shorter for downshifted saline than for saline rats always given access to the empty tube. This escape-from-frustration effect was eliminated by naloxone (2 mg/kg, i.p.). Opioid blockage appears to reduce the value of alternative incentives. © 2009 Elsevier Inc. All rights reserved.

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