Monogenic polyautoimmunity in primary immunodeficiency diseases.

G Azizi , R Yazdani , W Rae, H Abolhassani , M Rojas, A Aghamohammadi , Juan-Manuel Anaya

Resultado de la investigación: Tipos de Contribución a publicaciones especializadasArticulo

5 Citas (Scopus)

Resumen

Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, particularly autoimmunity. A specific group of monogenic PIDs are due to mutations in genes that are critical for the regulation of immunological tolerance and immune responses. This group of monogenic PIDs is at high risk of developing polyautoimmunity (i.e., the presence of more than one autoimmune disease in a single patient) because of their impaired immunity. In this review, we discuss the mechanisms of autoimmunity in PIDs and the characteristics of polyautoimmunity in the following PIDs: IPEX; monogenic IPEX-like syndrome; LRBA deficiency; CTLA4 deficiency; APECED; ALPS; and PKCδ deficiency.
Idioma originalSpanish (Colombia)
Páginas1028
Número de páginas1039
Volumen10
Publicación especializadaAutoimmunity Reviews
DOI
EstadoPublished - oct 17 2018

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Azizi , G., Yazdani , R., Rae, W., Abolhassani , H., Rojas, M., Aghamohammadi , A., & Anaya, J-M. (2018). Monogenic polyautoimmunity in primary immunodeficiency diseases. Autoimmunity Reviews, 10, 1028. https://doi.org/10.1016/j.autrev.2018.05.001
Azizi , G ; Yazdani , R ; Rae, W ; Abolhassani , H ; Rojas, M ; Aghamohammadi , A ; Anaya, Juan-Manuel. / Monogenic polyautoimmunity in primary immunodeficiency diseases. En: Autoimmunity Reviews. 2018 ; Vol. 10. pp. 1028.
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abstract = "Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, particularly autoimmunity. A specific group of monogenic PIDs are due to mutations in genes that are critical for the regulation of immunological tolerance and immune responses. This group of monogenic PIDs is at high risk of developing polyautoimmunity (i.e., the presence of more than one autoimmune disease in a single patient) because of their impaired immunity. In this review, we discuss the mechanisms of autoimmunity in PIDs and the characteristics of polyautoimmunity in the following PIDs: IPEX; monogenic IPEX-like syndrome; LRBA deficiency; CTLA4 deficiency; APECED; ALPS; and PKCδ deficiency.",
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Azizi , G, Yazdani , R, Rae, W, Abolhassani , H, Rojas, M, Aghamohammadi , A & Anaya, J-M 2018, 'Monogenic polyautoimmunity in primary immunodeficiency diseases.' Autoimmunity Reviews, vol. 10, pp. 1028. https://doi.org/10.1016/j.autrev.2018.05.001

Monogenic polyautoimmunity in primary immunodeficiency diseases. / Azizi , G; Yazdani , R; Rae, W; Abolhassani , H; Rojas, M; Aghamohammadi , A; Anaya, Juan-Manuel.

En: Autoimmunity Reviews, Vol. 10, 17.10.2018, p. 1028.

Resultado de la investigación: Tipos de Contribución a publicaciones especializadasArticulo

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AU - Yazdani , R

AU - Rae, W

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AU - Aghamohammadi , A

AU - Anaya, Juan-Manuel

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N2 - Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, particularly autoimmunity. A specific group of monogenic PIDs are due to mutations in genes that are critical for the regulation of immunological tolerance and immune responses. This group of monogenic PIDs is at high risk of developing polyautoimmunity (i.e., the presence of more than one autoimmune disease in a single patient) because of their impaired immunity. In this review, we discuss the mechanisms of autoimmunity in PIDs and the characteristics of polyautoimmunity in the following PIDs: IPEX; monogenic IPEX-like syndrome; LRBA deficiency; CTLA4 deficiency; APECED; ALPS; and PKCδ deficiency.

AB - Primary immunodeficiency diseases (PIDs) consist of a large group of genetic disorders that affect distinct components of the immune system. PID patients are susceptible to infection and non-infectious complications, particularly autoimmunity. A specific group of monogenic PIDs are due to mutations in genes that are critical for the regulation of immunological tolerance and immune responses. This group of monogenic PIDs is at high risk of developing polyautoimmunity (i.e., the presence of more than one autoimmune disease in a single patient) because of their impaired immunity. In this review, we discuss the mechanisms of autoimmunity in PIDs and the characteristics of polyautoimmunity in the following PIDs: IPEX; monogenic IPEX-like syndrome; LRBA deficiency; CTLA4 deficiency; APECED; ALPS; and PKCδ deficiency.

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JO - Autoimmunity Reviews

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Azizi G, Yazdani R, Rae W, Abolhassani H, Rojas M, Aghamohammadi A y otros. Monogenic polyautoimmunity in primary immunodeficiency diseases. Autoimmunity Reviews. 2018 oct 17;10:1028. https://doi.org/10.1016/j.autrev.2018.05.001