Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region

Título traducido de la contribución: Micro-epidemiología de las infecciones de malaria de especies mixtas en una población rural que vive en la región amazónica colombiana

Milena Camargo, Sara C Soto-De León, Luisa Del Río-Ospina, Astrid C Páez, Zanony González, Edgardo González, Juan R Cubides, Paola A Camargo-Ayala, Manuel E Patarroyo, Manuel A Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

4 Citas (Scopus)

Resumen

En los últimos años se han registrado brotes de paludismo en la región amazónica colombiana, y el paludismo ha reaparecido en zonas donde antes estaba controlado. La información de las redes de transmisión del paludismo y los conocimientos sobre las características de las poblaciones que influyen en la dispersión de las especies de parásitos son limitados. El objetivo de este estudio fue determinar los patrones de distribución de las infecciones únicas y mixtas de Plasmodium vivax, P. malariae y P. falciparum, así como las agrupaciones socio-espaciales significativas relacionadas con la aparición de tales infecciones. Una búsqueda activa en 57 localidades dio como resultado la inscripción de 2.106 pacientes sintomáticos. Los niveles de parasitemia se evaluaron mediante microscopía óptica, y los parásitos se detectaron mediante PCR. La asociación entre infecciones mixtas (en el 43,2% de la población) y factores socio-espaciales se modeló mediante regresión logística y análisis de correspondencia múltiple. P. vivax se presentó con mayor frecuencia (71.0%), seguido por P. malariae (43.2%), en todas las localidades. Los resultados sugieren que un modelo de regulación dependiente de la densidad de parásitos (en el que la fiebre juega un papel central) fue apropiado para modelar la frecuencia de infecciones de especies mixtas en esta población. Este estudio resalta la subregistro de infecciones mixtas por Plasmodium spp. en el área endémica de malaria de la región amazónica colombiana y la asociación entre los factores causales y ambientales en dichas áreas.
Idioma originalEnglish (US)
Páginas (desde-hasta)5543
Número de páginas14
PublicaciónScientific Reports
Volumen8
N.º1
DOI
EstadoPublished - abr 3 2018
Publicado de forma externa

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Camargo, Milena ; Soto-De León, Sara C ; Del Río-Ospina, Luisa ; Páez, Astrid C ; González, Zanony ; González, Edgardo ; Cubides, Juan R ; Camargo-Ayala, Paola A ; Patarroyo, Manuel E ; Patarroyo, Manuel A. / Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region. En: Scientific Reports. 2018 ; Vol. 8, N.º 1. pp. 5543.
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title = "Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region",
abstract = "Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2{\%} of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0{\%}), followed by P. malariae (43.2{\%}), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.",
author = "Milena Camargo and {Soto-De Le{\'o}n}, {Sara C} and {Del R{\'i}o-Ospina}, Luisa and P{\'a}ez, {Astrid C} and Zanony Gonz{\'a}lez and Edgardo Gonz{\'a}lez and Cubides, {Juan R} and Camargo-Ayala, {Paola A} and Patarroyo, {Manuel E} and Patarroyo, {Manuel A}",
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doi = "10.1038/s41598-018-23801-9",
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Camargo, M, Soto-De León, SC, Del Río-Ospina, L, Páez, AC, González, Z, González, E, Cubides, JR, Camargo-Ayala, PA, Patarroyo, ME & Patarroyo, MA 2018, 'Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region', Scientific Reports, vol. 8, n.º 1, pp. 5543. https://doi.org/10.1038/s41598-018-23801-9

Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region. / Camargo, Milena; Soto-De León, Sara C; Del Río-Ospina, Luisa; Páez, Astrid C; González, Zanony; González, Edgardo; Cubides, Juan R; Camargo-Ayala, Paola A; Patarroyo, Manuel E; Patarroyo, Manuel A.

En: Scientific Reports, Vol. 8, N.º 1, 03.04.2018, p. 5543.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region

AU - Camargo, Milena

AU - Soto-De León, Sara C

AU - Del Río-Ospina, Luisa

AU - Páez, Astrid C

AU - González, Zanony

AU - González, Edgardo

AU - Cubides, Juan R

AU - Camargo-Ayala, Paola A

AU - Patarroyo, Manuel E

AU - Patarroyo, Manuel A

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.

AB - Malaria outbreaks have been reported in recent years in the Colombian Amazon region, malaria has been re-emerging in areas where it was previously controlled. Information from malaria transmission networks and knowledge about the population characteristics influencing the dispersal of parasite species is limited. This study aimed to determine the distribution patterns of Plasmodium vivax, P. malariae and P. falciparum single and mixed infections, as well as the significant socio-spatial groupings relating to the appearance of such infections. An active search in 57 localities resulted in 2,106 symptomatic patients being enrolled. Parasitaemia levels were assessed by optical microscopy, and parasites were detected by PCR. The association between mixed infections (in 43.2% of the population) and socio-spatial factors was modelled using logistic regression and multiple correspondence analyses. P. vivax occurred most frequently (71.0%), followed by P. malariae (43.2%), in all localities. The results suggest that a parasite density-dependent regulation model (with fever playing a central role) was appropriate for modelling the frequency of mixed species infections in this population. This study highlights the under-reporting of Plasmodium spp. mixed infections in the malaria-endemic area of the Colombian Amazon region and the association between causative and environmental factors in such areas.

U2 - 10.1038/s41598-018-23801-9

DO - 10.1038/s41598-018-23801-9

M3 - Article

C2 - 29615693

VL - 8

SP - 5543

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

ER -

Camargo M, Soto-De León SC, Del Río-Ospina L, Páez AC, González Z, González E y otros. Micro-epidemiology of mixed-species malaria infections in a rural population living in the Colombian Amazon region. Scientific Reports. 2018 abr 3;8(1):5543. https://doi.org/10.1038/s41598-018-23801-9