Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis

Angélica M. Delgado-Vega, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaRevisión Literaria

45 Citas (Scopus)

Resumen

Objectives: To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data. Methods: Case-control studies on HLA-DRB1 association with RA in Latin America were searched up to October 2006. Genotype frequencies were extracted according to both shared epitope (SE) and HLA-DR4 positive or negative alleles. The effect summary odds ratio (OR) and 95% confidence intervals was obtained. Heterogeneity and publication bias were assessed. Results: Eight studies containing 684 cases and 1015 controls were included. Under the random effects model, the common OR was 3.28 (1.93, 5.60) (p <0.0001) and 3.54 (2.47, 5.05) (p = 4.22 × 10- 12) for HLA-DR4 and SE, respectively. There was no evidence of publication bias according to Funnel plot and Egger's regression test (p = 0,445 for DR4 and p = 0,464 for SE meta-analysis). Significant heterogeneity was observed for HLA-DR4 (I2 = 81.06%, Q = 36.96, p = 0.000005) but not for the SE meta-analysis. Conclusions: HLA-DR4 and SE positive HLA-DRB1 alleles (mainly HLA-DRB1*0404) are associated with RA in Latin Americans. Heterogeneity is expected owing to the diverse degree of admixture between the examined populations. Our findings support the HLA as a major susceptibility locus for RA and validate the SE hypothesis in Latin America. © 2007 Elsevier B.V. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)402-408
Número de páginas7
PublicaciónAutoimmunity Reviews
DOI
EstadoPublished - jun 1 2007

Huella dactilar

HLA-DRB1 Chains
HLA-DR4 Antigen
Meta-Analysis
Epitopes
Rheumatoid Arthritis
Latin America
Publication Bias
Alleles
Odds Ratio
Population
Case-Control Studies
Genotype
Confidence Intervals

Citar esto

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title = "Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis",
abstract = "Objectives: To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data. Methods: Case-control studies on HLA-DRB1 association with RA in Latin America were searched up to October 2006. Genotype frequencies were extracted according to both shared epitope (SE) and HLA-DR4 positive or negative alleles. The effect summary odds ratio (OR) and 95{\%} confidence intervals was obtained. Heterogeneity and publication bias were assessed. Results: Eight studies containing 684 cases and 1015 controls were included. Under the random effects model, the common OR was 3.28 (1.93, 5.60) (p <0.0001) and 3.54 (2.47, 5.05) (p = 4.22 × 10- 12) for HLA-DR4 and SE, respectively. There was no evidence of publication bias according to Funnel plot and Egger's regression test (p = 0,445 for DR4 and p = 0,464 for SE meta-analysis). Significant heterogeneity was observed for HLA-DR4 (I2 = 81.06{\%}, Q = 36.96, p = 0.000005) but not for the SE meta-analysis. Conclusions: HLA-DR4 and SE positive HLA-DRB1 alleles (mainly HLA-DRB1*0404) are associated with RA in Latin Americans. Heterogeneity is expected owing to the diverse degree of admixture between the examined populations. Our findings support the HLA as a major susceptibility locus for RA and validate the SE hypothesis in Latin America. {\circledC} 2007 Elsevier B.V. All rights reserved.",
author = "Delgado-Vega, {Ang{\'e}lica M.} and Anaya, {Juan Manuel}",
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Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis. / Delgado-Vega, Angélica M.; Anaya, Juan Manuel.

En: Autoimmunity Reviews, 01.06.2007, p. 402-408.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis

AU - Delgado-Vega, Angélica M.

AU - Anaya, Juan Manuel

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Objectives: To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data. Methods: Case-control studies on HLA-DRB1 association with RA in Latin America were searched up to October 2006. Genotype frequencies were extracted according to both shared epitope (SE) and HLA-DR4 positive or negative alleles. The effect summary odds ratio (OR) and 95% confidence intervals was obtained. Heterogeneity and publication bias were assessed. Results: Eight studies containing 684 cases and 1015 controls were included. Under the random effects model, the common OR was 3.28 (1.93, 5.60) (p <0.0001) and 3.54 (2.47, 5.05) (p = 4.22 × 10- 12) for HLA-DR4 and SE, respectively. There was no evidence of publication bias according to Funnel plot and Egger's regression test (p = 0,445 for DR4 and p = 0,464 for SE meta-analysis). Significant heterogeneity was observed for HLA-DR4 (I2 = 81.06%, Q = 36.96, p = 0.000005) but not for the SE meta-analysis. Conclusions: HLA-DR4 and SE positive HLA-DRB1 alleles (mainly HLA-DRB1*0404) are associated with RA in Latin Americans. Heterogeneity is expected owing to the diverse degree of admixture between the examined populations. Our findings support the HLA as a major susceptibility locus for RA and validate the SE hypothesis in Latin America. © 2007 Elsevier B.V. All rights reserved.

AB - Objectives: To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data. Methods: Case-control studies on HLA-DRB1 association with RA in Latin America were searched up to October 2006. Genotype frequencies were extracted according to both shared epitope (SE) and HLA-DR4 positive or negative alleles. The effect summary odds ratio (OR) and 95% confidence intervals was obtained. Heterogeneity and publication bias were assessed. Results: Eight studies containing 684 cases and 1015 controls were included. Under the random effects model, the common OR was 3.28 (1.93, 5.60) (p <0.0001) and 3.54 (2.47, 5.05) (p = 4.22 × 10- 12) for HLA-DR4 and SE, respectively. There was no evidence of publication bias according to Funnel plot and Egger's regression test (p = 0,445 for DR4 and p = 0,464 for SE meta-analysis). Significant heterogeneity was observed for HLA-DR4 (I2 = 81.06%, Q = 36.96, p = 0.000005) but not for the SE meta-analysis. Conclusions: HLA-DR4 and SE positive HLA-DRB1 alleles (mainly HLA-DRB1*0404) are associated with RA in Latin Americans. Heterogeneity is expected owing to the diverse degree of admixture between the examined populations. Our findings support the HLA as a major susceptibility locus for RA and validate the SE hypothesis in Latin America. © 2007 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.autrev.2006.11.004

DO - 10.1016/j.autrev.2006.11.004

M3 - Literature review

SP - 402

EP - 408

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

ER -