Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review

Carlos Alberto Calderon Ospina; Mauricio Orlando Nava Mesa; Ana María Paez-Hurtado

doi:10.1080/1028415X.2022.2034242

Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review

Título traducido de la contribución: Mecanismos de acción de la vitamina B1 (tiamina), B6 (piridoxina) y B12 (cobalamina) en el dolor: una revisión narrativa

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

54 Citas (Scopus)

Resumen

El dolor es una experiencia sensorial y emocional compleja con componentes nociceptivos, nociplásicos y neuropáticos. Se ha discutido durante mucho tiempo la implicación de las vitaminas B neurotrópicas (B1 - tiamina, B6 - piridoxina y B12 - cianocobalamina) como moduladores de la inflamación y el dolor. Nueva evidencia sugiere su potencial terapéutico en diferentes condiciones de dolor. En esta revisión, discutimos el papel principal de las vitaminas B neurotrópicas en diferentes vías nociceptivas en el sistema nervioso y describimos sus mecanismos de acción analgésica. La revisión bibliográfica realizada mostró que, a través de diferentes mecanismos, estas vitaminas regulan varios mediadores inflamatorios y neurales en el dolor nociceptivo y neuropático. Algunos de estos procesos incluyen la activación del sistema modulador del dolor descendente y, en vías intracelulares específicas, efectos antiinflamatorios, antioxidantes y regeneradores nerviosos. Además, datos recientes muestran los efectos antinociceptivos, antialodínicos y antihiperalgésicos de la combinación de estas vitaminas, así como sus efectos sinérgicos con analgésicos conocidos. Por lo tanto, comprender cómo las vitaminas B1, B6 y B12 afectan varios mecanismos nociceptivos puede ser importante en el tratamiento de diversas afecciones dolorosas.

Título traducido de la contribución	Mecanismos de acción de la vitamina B1 (tiamina), B6 (piridoxina) y B12 (cobalamina) en el dolor: una revisión narrativa
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1-19
Número de páginas	19
Publicación	Nutritional Neuroscience
Volumen	26
N.º	3
Fecha en línea anticipada	feb 14 2022
DOI	https://doi.org/10.1080/1028415X.2022.2034242
Estado	Publicada - feb 14 2022

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ODS 3: Salud y bienestar

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Neurociencia celular y molecular

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10.1080/1028415X.2022.2034242

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title = "Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review",

abstract = "Pain is a complex sensory and emotional experience with nociceptive, nociplastic, and neuropathic components. An involvement of neurotropic B vitamins (B1{\textendash}thiamine, B6{\textendash}pyridoxine, and B12{\textendash}cyanocobalamin) as modulators of inflammation and pain has been long discussed. New evidence suggests their therapeutic potential in different pain conditions. In this review, we discuss the main role of neurotropic B vitamins on different nociceptive pathways in the nervous system and to describe their analgesic action mechanisms. The performed literature review showed that, through different mechanisms, these vitamins regulate several inflammatory and neural mediators in nociceptive and neuropathic pain. Some of these processes include aiming the activation of the descending pain modulatory system and in specific intracellular pathways, anti-inflammatory, antioxidative and nerve regenerative effects. Moreover, recent data shows the antinociceptive, antiallodynic, and anti-hyperalgesic effects of the combination of these vitamins, as well as their synergistic effects with known analgesics. Understanding how vitamins B1, B6, and B12 affect several nociceptive mechanisms can therefore be of significance in the treatment of various pain conditions.",

author = "\{Calderon Ospina\}, \{Carlos Alberto\} and \{Nava Mesa\}, \{Mauricio Orlando\} and Paez-Hurtado, \{Ana Mar{\'i}a\}",

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Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review. / Calderon Ospina, Carlos Alberto ; Nava Mesa, Mauricio Orlando; Paez-Hurtado, Ana María.
En: Nutritional Neuroscience, Vol. 26, N.º 3, 14.02.2022, p. 1-19.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review

AU - Calderon Ospina, Carlos Alberto

AU - Nava Mesa, Mauricio Orlando

AU - Paez-Hurtado, Ana María

PY - 2022/2/14

Y1 - 2022/2/14

N2 - Pain is a complex sensory and emotional experience with nociceptive, nociplastic, and neuropathic components. An involvement of neurotropic B vitamins (B1–thiamine, B6–pyridoxine, and B12–cyanocobalamin) as modulators of inflammation and pain has been long discussed. New evidence suggests their therapeutic potential in different pain conditions. In this review, we discuss the main role of neurotropic B vitamins on different nociceptive pathways in the nervous system and to describe their analgesic action mechanisms. The performed literature review showed that, through different mechanisms, these vitamins regulate several inflammatory and neural mediators in nociceptive and neuropathic pain. Some of these processes include aiming the activation of the descending pain modulatory system and in specific intracellular pathways, anti-inflammatory, antioxidative and nerve regenerative effects. Moreover, recent data shows the antinociceptive, antiallodynic, and anti-hyperalgesic effects of the combination of these vitamins, as well as their synergistic effects with known analgesics. Understanding how vitamins B1, B6, and B12 affect several nociceptive mechanisms can therefore be of significance in the treatment of various pain conditions.

AB - Pain is a complex sensory and emotional experience with nociceptive, nociplastic, and neuropathic components. An involvement of neurotropic B vitamins (B1–thiamine, B6–pyridoxine, and B12–cyanocobalamin) as modulators of inflammation and pain has been long discussed. New evidence suggests their therapeutic potential in different pain conditions. In this review, we discuss the main role of neurotropic B vitamins on different nociceptive pathways in the nervous system and to describe their analgesic action mechanisms. The performed literature review showed that, through different mechanisms, these vitamins regulate several inflammatory and neural mediators in nociceptive and neuropathic pain. Some of these processes include aiming the activation of the descending pain modulatory system and in specific intracellular pathways, anti-inflammatory, antioxidative and nerve regenerative effects. Moreover, recent data shows the antinociceptive, antiallodynic, and anti-hyperalgesic effects of the combination of these vitamins, as well as their synergistic effects with known analgesics. Understanding how vitamins B1, B6, and B12 affect several nociceptive mechanisms can therefore be of significance in the treatment of various pain conditions.

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Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review

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