Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population

L. M. Gómez, E. Sánchez, E. A. Ruiz-Narvaez, M. A. López-Nevot, J. M. Anaya, J. Martín

Resultado de la investigación: Contribución a RevistaArtículo

28 Citas (Scopus)

Resumen

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population. © 2007 Blackwell Munksgaard.
Idioma originalEnglish (US)
Páginas (desde-hasta)28-33
Número de páginas6
PublicaciónTissue Antigens
DOI
EstadoPublished - jul 1 2007

Huella dactilar

Macrophage Migration-Inhibitory Factors
Tuberculosis
Microsatellite Repeats
Alleles
Population
Genes
Tuberculin Test
Virus Diseases
Skin Tests
Pulmonary Tuberculosis
Innate Immunity
Single Nucleotide Polymorphism
Multivariate Analysis
Odds Ratio
HIV
Confidence Intervals
Cytokines

Citar esto

Gómez, L. M. ; Sánchez, E. ; Ruiz-Narvaez, E. A. ; López-Nevot, M. A. ; Anaya, J. M. ; Martín, J. / Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population. En: Tissue Antigens. 2007 ; pp. 28-33.
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title = "Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population",
abstract = "Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95{\%} confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population. {\circledC} 2007 Blackwell Munksgaard.",
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Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population. / Gómez, L. M.; Sánchez, E.; Ruiz-Narvaez, E. A.; López-Nevot, M. A.; Anaya, J. M.; Martín, J.

En: Tissue Antigens, 01.07.2007, p. 28-33.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population

AU - Gómez, L. M.

AU - Sánchez, E.

AU - Ruiz-Narvaez, E. A.

AU - López-Nevot, M. A.

AU - Anaya, J. M.

AU - Martín, J.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population. © 2007 Blackwell Munksgaard.

AB - Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population. © 2007 Blackwell Munksgaard.

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DO - 10.1111/j.1399-0039.2007.00843.x

M3 - Article

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JF - HLA

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