Lupus nephritis in colombians: Contrasts and comparisons with other populations

Juan Manuel Anaya, Carlos Cañas, Rubén D. Mantilla, Ricardo Pineda-Tamayo, Gabriel J. Tobón, Catalina Herrera-Diaz, Diego M. Rendón, Adriana Rojas-Villarraga, Mauricio Uribe

Resultado de la investigación: Contribución a RevistaArtículo

19 Citas (Scopus)

Resumen

Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. The purpose of this study was to examine the clinical and immunological characteristics associated with LN development during the course of SLE in Colombians. Therefore, patients with SLE followed at five different referral centers in Medellin, Bogota, and Cali were included in this cross-sectional and multicenter study. Factors influencing LN were assessed by conditional logistic regression analysis, adjusting by gender, age at onset, duration of disease, and city of origin. The entire sample population included 467 patients, of whom 51% presented with LN. The presence of anti-dsDNA antibodies (adjusted odds ratio (AOR), 2.06; 95% confidence interval (CI), 1.16-3.65), pleuritis (AOR, 3.82; 95% CI, 1.38-10.54), and hypertension (AOR, 2.63; 95% CI, 1.23-5.62) were positively associated with LN, whereas the presence of anti-La antibodies was a protective factor against LN development (AOR, 0.4; 95% CI, 0.19-0.85). A review of literature on LN in different populations is made. The identified clinical- and laboratory-associated factors would assist earlier diagnosis and guide decisions on therapeutic interventions on this critical and frequent complication of SLE. © Springer Science+Business Media, LLC 2011.
Idioma originalEnglish (US)
Páginas (desde-hasta)199-207
Número de páginas9
PublicaciónClinical Reviews in Allergy and Immunology
DOI
EstadoPublished - jun 1 2011

Huella dactilar

Lupus Nephritis
Systemic Lupus Erythematosus
Population
Odds Ratio
Confidence Intervals
Anti-Idiotypic Antibodies
Pleurisy
Age of Onset
Multicenter Studies
Early Diagnosis
Referral and Consultation
Cross-Sectional Studies
Logistic Models
Regression Analysis
Hypertension

Citar esto

Anaya, J. M., Cañas, C., Mantilla, R. D., Pineda-Tamayo, R., Tobón, G. J., Herrera-Diaz, C., ... Uribe, M. (2011). Lupus nephritis in colombians: Contrasts and comparisons with other populations. Clinical Reviews in Allergy and Immunology, 199-207. https://doi.org/10.1007/s12016-010-8249-4
Anaya, Juan Manuel ; Cañas, Carlos ; Mantilla, Rubén D. ; Pineda-Tamayo, Ricardo ; Tobón, Gabriel J. ; Herrera-Diaz, Catalina ; Rendón, Diego M. ; Rojas-Villarraga, Adriana ; Uribe, Mauricio. / Lupus nephritis in colombians: Contrasts and comparisons with other populations. En: Clinical Reviews in Allergy and Immunology. 2011 ; pp. 199-207.
@article{90affafd7a8647b79459e42c93e6eda1,
title = "Lupus nephritis in colombians: Contrasts and comparisons with other populations",
abstract = "Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. The purpose of this study was to examine the clinical and immunological characteristics associated with LN development during the course of SLE in Colombians. Therefore, patients with SLE followed at five different referral centers in Medellin, Bogota, and Cali were included in this cross-sectional and multicenter study. Factors influencing LN were assessed by conditional logistic regression analysis, adjusting by gender, age at onset, duration of disease, and city of origin. The entire sample population included 467 patients, of whom 51{\%} presented with LN. The presence of anti-dsDNA antibodies (adjusted odds ratio (AOR), 2.06; 95{\%} confidence interval (CI), 1.16-3.65), pleuritis (AOR, 3.82; 95{\%} CI, 1.38-10.54), and hypertension (AOR, 2.63; 95{\%} CI, 1.23-5.62) were positively associated with LN, whereas the presence of anti-La antibodies was a protective factor against LN development (AOR, 0.4; 95{\%} CI, 0.19-0.85). A review of literature on LN in different populations is made. The identified clinical- and laboratory-associated factors would assist earlier diagnosis and guide decisions on therapeutic interventions on this critical and frequent complication of SLE. {\circledC} Springer Science+Business Media, LLC 2011.",
author = "Anaya, {Juan Manuel} and Carlos Ca{\~n}as and Mantilla, {Rub{\'e}n D.} and Ricardo Pineda-Tamayo and Tob{\'o}n, {Gabriel J.} and Catalina Herrera-Diaz and Rend{\'o}n, {Diego M.} and Adriana Rojas-Villarraga and Mauricio Uribe",
year = "2011",
month = "6",
day = "1",
doi = "10.1007/s12016-010-8249-4",
language = "English (US)",
pages = "199--207",
journal = "Clinical Reviews in Allergy and Immunology",
issn = "1080-0549",
publisher = "Humana Press",

}

Anaya, JM, Cañas, C, Mantilla, RD, Pineda-Tamayo, R, Tobón, GJ, Herrera-Diaz, C, Rendón, DM, Rojas-Villarraga, A & Uribe, M 2011, 'Lupus nephritis in colombians: Contrasts and comparisons with other populations', Clinical Reviews in Allergy and Immunology, pp. 199-207. https://doi.org/10.1007/s12016-010-8249-4

Lupus nephritis in colombians: Contrasts and comparisons with other populations. / Anaya, Juan Manuel; Cañas, Carlos; Mantilla, Rubén D.; Pineda-Tamayo, Ricardo; Tobón, Gabriel J.; Herrera-Diaz, Catalina; Rendón, Diego M.; Rojas-Villarraga, Adriana; Uribe, Mauricio.

En: Clinical Reviews in Allergy and Immunology, 01.06.2011, p. 199-207.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Lupus nephritis in colombians: Contrasts and comparisons with other populations

AU - Anaya, Juan Manuel

AU - Cañas, Carlos

AU - Mantilla, Rubén D.

AU - Pineda-Tamayo, Ricardo

AU - Tobón, Gabriel J.

AU - Herrera-Diaz, Catalina

AU - Rendón, Diego M.

AU - Rojas-Villarraga, Adriana

AU - Uribe, Mauricio

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. The purpose of this study was to examine the clinical and immunological characteristics associated with LN development during the course of SLE in Colombians. Therefore, patients with SLE followed at five different referral centers in Medellin, Bogota, and Cali were included in this cross-sectional and multicenter study. Factors influencing LN were assessed by conditional logistic regression analysis, adjusting by gender, age at onset, duration of disease, and city of origin. The entire sample population included 467 patients, of whom 51% presented with LN. The presence of anti-dsDNA antibodies (adjusted odds ratio (AOR), 2.06; 95% confidence interval (CI), 1.16-3.65), pleuritis (AOR, 3.82; 95% CI, 1.38-10.54), and hypertension (AOR, 2.63; 95% CI, 1.23-5.62) were positively associated with LN, whereas the presence of anti-La antibodies was a protective factor against LN development (AOR, 0.4; 95% CI, 0.19-0.85). A review of literature on LN in different populations is made. The identified clinical- and laboratory-associated factors would assist earlier diagnosis and guide decisions on therapeutic interventions on this critical and frequent complication of SLE. © Springer Science+Business Media, LLC 2011.

AB - Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. The purpose of this study was to examine the clinical and immunological characteristics associated with LN development during the course of SLE in Colombians. Therefore, patients with SLE followed at five different referral centers in Medellin, Bogota, and Cali were included in this cross-sectional and multicenter study. Factors influencing LN were assessed by conditional logistic regression analysis, adjusting by gender, age at onset, duration of disease, and city of origin. The entire sample population included 467 patients, of whom 51% presented with LN. The presence of anti-dsDNA antibodies (adjusted odds ratio (AOR), 2.06; 95% confidence interval (CI), 1.16-3.65), pleuritis (AOR, 3.82; 95% CI, 1.38-10.54), and hypertension (AOR, 2.63; 95% CI, 1.23-5.62) were positively associated with LN, whereas the presence of anti-La antibodies was a protective factor against LN development (AOR, 0.4; 95% CI, 0.19-0.85). A review of literature on LN in different populations is made. The identified clinical- and laboratory-associated factors would assist earlier diagnosis and guide decisions on therapeutic interventions on this critical and frequent complication of SLE. © Springer Science+Business Media, LLC 2011.

U2 - 10.1007/s12016-010-8249-4

DO - 10.1007/s12016-010-8249-4

M3 - Article

SP - 199

EP - 207

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

ER -

Anaya JM, Cañas C, Mantilla RD, Pineda-Tamayo R, Tobón GJ, Herrera-Diaz C y otros. Lupus nephritis in colombians: Contrasts and comparisons with other populations. Clinical Reviews in Allergy and Immunology. 2011 jun 1;199-207. https://doi.org/10.1007/s12016-010-8249-4