Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.

JE Correa-Bautista, Robinson Ramírez-Vélez, José Francisco Meneses-Echavez

Resultado de la investigación: Contribución a RevistaArtículo

Resumen

Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-α (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.
Idioma originalEnglish (US)
Páginas (desde-hasta)5-5
Número de páginas1
PublicaciónJournal of Clinical Oncology
Volumen33
N.º15
DOI
EstadoPublished - 2015

Huella dactilar

Meta-Analysis
Exercise
Breast Neoplasms
Inflammation
Survivors
Publication Bias
Tumor Microenvironment
Randomized Controlled Trials
Serum
Interleukin-8
PubMed
Interleukin-10
C-Reactive Protein
Interleukin-2
Interleukin-6
Anti-Inflammatory Agents
Language
Tumor Necrosis Factor-alpha
Research Personnel
Databases

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Correa-Bautista, JE ; Ramírez-Vélez, Robinson ; Meneses-Echavez, José Francisco. / Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression. En: Journal of Clinical Oncology. 2015 ; Vol. 33, N.º 15. pp. 5-5.
@article{ebd51efd2aad40ecbc1ddba02b10b2bd,
title = "Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.",
abstract = "Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25{\%}, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50{\%}). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95{\%}CI -0.61 to -0.12), IL-2 (MD = 1.03, 95{\%}CI 0.39 to 1.66), IL-8 (MD = -0.49, 95{\%}CI -0.89 to-0.08) and TNF-α (MD = -0.48, 95{\%}CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.",
author = "JE Correa-Bautista and Robinson Ram{\'i}rez-V{\'e}lez and Meneses-Echavez, {Jos{\'e} Francisco}",
year = "2015",
doi = "10.1200/jco.2015.33.15_suppl.e12581",
language = "English (US)",
volume = "33",
pages = "5--5",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
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Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression. / Correa-Bautista, JE; Ramírez-Vélez, Robinson; Meneses-Echavez, José Francisco.

En: Journal of Clinical Oncology, Vol. 33, N.º 15, 2015, p. 5-5.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.

AU - Correa-Bautista, JE

AU - Ramírez-Vélez, Robinson

AU - Meneses-Echavez, José Francisco

PY - 2015

Y1 - 2015

N2 - Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-α (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.

AB - Background: Strong evidence has demonstrated that exercise training reduces breast cancer risk by 10-25%, and several biological mechanisms have been proposed to explain the positive modulation of inflammatory mediators associated with the tumor microenvironment. This study aims to determine the effects of exercise training on markers of low-grade inflammation in breast cancer survivors. Methods: A systematic literature review of randomized controlled trials (RCTs) evaluating the changes in inflammatory mediators in breast cancer survivors after exercise training was performed. The PubMed, Embase, Scopus and CENTRAL databases and other gray literature resources were searched without language restrictions from January 1990 to March 2014. Two investigators screened and identified the studies that met the inclusion criteria. An inverse of variance model of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity (I2< 50%). Publication bias was evaluated using Egger’s test (p < 0.05). Results: Nine high-quality RCTs (n = 349) were ultimately included. Exercise training improved the serum concentrations of IL-6 (mean difference (MD) = -0.37, 95%CI -0.61 to -0.12), IL-2 (MD = 1.03, 95%CI 0.39 to 1.66), IL-8 (MD = -0.49, 95%CI -0.89 to-0.08) and TNF-α (MD = -0.48, 95%CI -0.96 to -0.003, p = 0.04). Conversely, no significant differences were found in the serum concentrations of C-reactive protein (CRP) or IL-10. There was no evidence of publication bias (p= 0.06). Conclusions: Exercise training positively modulates low-grade inflammation in women with breast cancer, impacting carcinogenic mechanisms and the tumor microenvironment. Additional RCTs are required to further elucidate the anti-inflammatory effects of exercise on breast cancer survivors.

U2 - 10.1200/jco.2015.33.15_suppl.e12581

DO - 10.1200/jco.2015.33.15_suppl.e12581

M3 - Article

VL - 33

SP - 5

EP - 5

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 15

ER -