Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

Diego Garzón-Ospina, Liza Romero-Murillo, Luisa F. Tobón, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

17 Citas (Scopus)

Resumen

The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.
Idioma originalEnglish (US)
Páginas (desde-hasta)528-531
Número de páginas4
PublicaciónInfection, Genetics and Evolution
DOI
EstadoPublished - mar 1 2011

Huella dactilar

Plasmodium vivax
Merozoites
merozoites
surface proteins
vaccine
Genetic Polymorphisms
Membrane Proteins
polymorphism
malaria
genetic polymorphism
genetic variation
protein
Vaccines
Vivax Malaria
Malaria Vaccines
Genetic Drift
Subunit Vaccines
Plasmodium
Colombia
gene

Citar esto

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abstract = "The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. {\circledC} 2010 Elsevier B.V.",
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Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates. / Garzón-Ospina, Diego; Romero-Murillo, Liza; Tobón, Luisa F.; Patarroyo, Manuel A.

En: Infection, Genetics and Evolution, 01.03.2011, p. 528-531.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

AU - Garzón-Ospina, Diego

AU - Romero-Murillo, Liza

AU - Tobón, Luisa F.

AU - Patarroyo, Manuel A.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.

AB - The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.

U2 - 10.1016/j.meegid.2010.12.002

DO - 10.1016/j.meegid.2010.12.002

M3 - Article

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SP - 528

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JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

SN - 1567-1348

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