Long-term nightshift work and breast cancer risk: An updated systematic review and meta-analysis with special attention to menopausal status and to recent nightshift work

Christine Schwarz, Ana María Pedraza-Flechas, Roberto Pastor-Barriuso, Virginia Lope, Nerea Fernández de Larrea, José Juan Jiménez-Moleón, Marina Pollán, Beatriz Pérez-Gómez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

This systematic review discusses long-term NSW and female BC risk, with special attention to differences between pre- and postmenopausal BC, to test the association with recent NSW. The review follows PRISMA guidelines (Prospero registry: CRD42018102515). We searched PubMed, Embase, and WOS for case–control, nested case–control, and cohort studies addressing long-term NSW (≥15 years) as risk exposure and female BC as outcome until 31 December 2020. Risk of bias was evaluated with the Newcastle–Ottawa scale. Eighteen studies were finally included (eight cohorts; five nested case–control; five case–control). We performed meta-analyses on long-term NSW and BC risk; overall and by menopausal status; a subanalysis on recent long-term NSW, based on studies involving predominantly women below retirement age; and a dose–response meta-analysis on NSW duration. The pooled estimate for long-term NSW and BC was 1.13 (95%CI = 1.01–1.27; 18 studies, I2 = 56.8%, p = 0.002). BC risk increased 4.7% per 10 years of NSW (95%CI = 0.94–1.09; 16 studies, I2 = 33.4%, p = 0.008). The pooled estimate for premenopausal BC was 1.27 (95%CI = 0.96–1.68; six studies, I2 = 32.0%, p = 0.196) and for postmenopausal BC 1.05 (95%CI = 0.90–1.24,I2 = 52.4%; seven studies, p = 0.050). For recent long-term exposure, the pooled estimate was 1.23 (95%CI = 1.06–1.42; 15 studies; I2 = 48.4%, p = 0.018). Our results indicate that long-term NSW increases the risk for BC and that menopausal status and time since exposure might be relevant.
Idioma originalInglés estadounidense
Número de artículo5952
PublicaciónCancers
Volumen13
N.º23
DOI
EstadoPublicada - nov. 26 2021

Áreas temáticas de ASJC Scopus

  • Oncología
  • Investigación sobre el cáncer

Palabras claves de autor

  • Concepto
  • nightshift work
  • breast cancer
  • recent exposure
  • meta-analysis
  • menopausal status
  • occupational exposure
  • retirement age

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