Leptin

Role over central nervous system in epilepsy

Título traducido de la contribución: Leptin : Papel sobre el sistema nervioso central en la epilepsia

Laura Mora-Muñoz, Alejandro Guerrero-Naranjo, Elisa Angélica Rodríguez-Jimenez, Claudio Alberto Mastronardi, Alberto Velez-van-Meerbeke

Resultado de la investigación: Contribución a RevistaArtículo de revisión

Resumen

El tejido adiposo es un órgano dinámico con diferentes efectos en el cuerpo. Muchos de estos efectos están mediados por la leptina, una hormona muy implicada en la regulación de la alimentación y el metabolismo energético. Tiene un papel importante como mediador de la actividad excitadora neuronal y de las funciones cerebrales superiores. El objetivo de este estudio fue revisar la asociación entre la leptina y la función neuronal cerebral, en particular sus efectos anticonvulsivos o convulsivos y la posible función terapéutica en el tratamiento de la epilepsia. Para este propósito, se realizaron búsquedas en las bases de datos Pubmed, Science Direct, Elsevier, ResearchGate y Scielo para identificar estudios experimentales, revisiones y artículos de revisión sistemática, publicados en inglés, español o portugués. Los estudios experimentales y la presencia de receptores de leptina en sitios del sistema nervioso distintos del hipotálamo sugieren una influencia en las funciones cerebrales superiores. De hecho, varios estudios en animales han demostrado el papel de estos canales en la actividad epiléptica, ya que se han encontrado efectos tanto anticonvulsivos como convulsivos. La razón de estas discrepancias no está clara, pero proporciona pruebas claras de una función potencial de la leptina y el tratamiento con leptina en la actividad epiléptica. La asociación entre la leptina y la función cerebral demuestra la importancia de las hormonas metabólicas periféricas en el sistema nervioso central y abre un nuevo camino para el desarrollo de nuevas intervenciones terapéuticas en enfermedades como la epilepsia. Sin embargo, es importante realizar más investigaciones para aclarar la dinámica y las diversas acciones de la leptina sobre la regulación excitatoria en el cerebro.
Idioma originalEnglish (US)
Número de artículo51
PublicaciónBMC Neuroscience
Volumen19
N.º1
DOI
EstadoPublished - sep 5 2018

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Citar esto

Mora-Muñoz, L., Guerrero-Naranjo, A., Rodríguez-Jimenez, E. A., Mastronardi, C. A., & Velez-van-Meerbeke, A. (2018). Leptin: Role over central nervous system in epilepsy. BMC Neuroscience, 19(1), [51]. https://doi.org/10.1186/s12868-018-0453-9
Mora-Muñoz, Laura ; Guerrero-Naranjo, Alejandro ; Rodríguez-Jimenez, Elisa Angélica ; Mastronardi, Claudio Alberto ; Velez-van-Meerbeke, Alberto. / Leptin : Role over central nervous system in epilepsy. En: BMC Neuroscience. 2018 ; Vol. 19, N.º 1.
@article{b20fa05c82824d088dfaf4e44ee9e670,
title = "Leptin: Role over central nervous system in epilepsy",
abstract = "Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain.",
author = "Laura Mora-Mu{\~n}oz and Alejandro Guerrero-Naranjo and Rodr{\'i}guez-Jimenez, {Elisa Ang{\'e}lica} and Mastronardi, {Claudio Alberto} and Alberto Velez-van-Meerbeke",
year = "2018",
month = "9",
day = "5",
doi = "10.1186/s12868-018-0453-9",
language = "English (US)",
volume = "19",
journal = "BMC Neuroscience",
issn = "1471-2202",
publisher = "BioMed Central",
number = "1",

}

Mora-Muñoz, L, Guerrero-Naranjo, A, Rodríguez-Jimenez, EA, Mastronardi, CA & Velez-van-Meerbeke, A 2018, 'Leptin: Role over central nervous system in epilepsy', BMC Neuroscience, vol. 19, n.º 1, 51. https://doi.org/10.1186/s12868-018-0453-9

Leptin : Role over central nervous system in epilepsy. / Mora-Muñoz, Laura; Guerrero-Naranjo, Alejandro; Rodríguez-Jimenez, Elisa Angélica; Mastronardi, Claudio Alberto; Velez-van-Meerbeke, Alberto.

En: BMC Neuroscience, Vol. 19, N.º 1, 51, 05.09.2018.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Leptin

T2 - Role over central nervous system in epilepsy

AU - Mora-Muñoz, Laura

AU - Guerrero-Naranjo, Alejandro

AU - Rodríguez-Jimenez, Elisa Angélica

AU - Mastronardi, Claudio Alberto

AU - Velez-van-Meerbeke, Alberto

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain.

AB - Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain.

UR - http://www.scopus.com/inward/record.url?scp=85052921371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052921371&partnerID=8YFLogxK

U2 - 10.1186/s12868-018-0453-9

DO - 10.1186/s12868-018-0453-9

M3 - Review article

VL - 19

JO - BMC Neuroscience

JF - BMC Neuroscience

SN - 1471-2202

IS - 1

M1 - 51

ER -

Mora-Muñoz L, Guerrero-Naranjo A, Rodríguez-Jimenez EA, Mastronardi CA, Velez-van-Meerbeke A. Leptin: Role over central nervous system in epilepsy. BMC Neuroscience. 2018 sep 5;19(1). 51. https://doi.org/10.1186/s12868-018-0453-9