TY - JOUR
T1 - LDH-A and α-actin as tools to assess the effects of temperature on the vertebrate genome
T2 - Some problems
AU - Clay, Oliver
AU - Arhondakis, Stilianos
AU - D'Onofrio, Giuseppe
AU - Bernardi, Giorgio
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/10/23
Y1 - 2003/10/23
N2 - In a recent paper written with the purpose of shedding light on the question of whether genomic GC levels are related to temperature in vertebrates, Ream et al. [Mol. Biol. Evol. 20 (2003) 105] offered an analysis of two sets of homologous genes: those coding for α-actin and lactate dehydrogenase-A (LDH-A). The conclusion was that "there is no consistent relationship between adaptation temperature and the percentage of thermal stability-enhancing G+C base pairs in protein-coding genes". We argue here that the data presented neither prove nor suggest such a conclusion because of conceptual and methodological errors.
AB - In a recent paper written with the purpose of shedding light on the question of whether genomic GC levels are related to temperature in vertebrates, Ream et al. [Mol. Biol. Evol. 20 (2003) 105] offered an analysis of two sets of homologous genes: those coding for α-actin and lactate dehydrogenase-A (LDH-A). The conclusion was that "there is no consistent relationship between adaptation temperature and the percentage of thermal stability-enhancing G+C base pairs in protein-coding genes". We argue here that the data presented neither prove nor suggest such a conclusion because of conceptual and methodological errors.
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U2 - 10.1016/S0378-1119(03)00698-X
DO - 10.1016/S0378-1119(03)00698-X
M3 - Article
C2 - 14604804
AN - SCOPUS:0242290120
SN - 0378-1119
VL - 317
SP - 157
EP - 160
JO - Gene
JF - Gene
IS - 1-2
ER -