Lack of association of polymorphisms in six candidate genes in colombian adhd patients

Resultado de la investigación: Contribución a RevistaArtículo

9 Citas (Scopus)

Resumen

Background: Attention Deficit and Hyperactivity Disorder (ADHD) is a common childhood neuropsychiatric
condition. The disorder has a multifactorial background, with heritability estimates of around 76%, suggesting
an important role of genetic factors. Candidate genes include those related to dopaminergic (e.g.
DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways.
Purpose: To explore the association of common polymorphisms in six genes (DRD4, DRD5, SLC6A3, DBH,
HTR1B and SLC6A4) and the susceptibility to ADHD in a Colombian sample population.
Methods: Eighty-six ADHD trios and 152 healthy controls were recruited. Genotyping of the six polymorphisms
was performed using described PCR-based protocols. A TDT analysis was used to test if there was
preferential allelic transmission for any of the six polymorphisms. Additionally, a case-control analysis was
performed to test for association of the serotoninergic (HTR1B and SLC6A4) polymorphisms with ADHD.
Results: Through the TDT analysis there was no preferential allelic transmission for any of the studied variants.
Case-control analysis did not show association.
Conclusion: This is the first study in Latin America to describe six polymorphisms in a group of patients
with ADHD. There was no evidence of association for any of the studied polymorphic variants in this Colombian
ADHD sample. Further research, with larger sample sizes and study of endophenotypes, is needed
in this population to confirm and extend the results
Idioma originalEnglish (US)
Páginas (desde-hasta)217-221
Número de páginas4
PublicaciónAnnals of Neurosciences
Volumen22
N.º4
DOI
EstadoPublished - oct 16 2015

Huella dactilar

Attention Deficit Disorder with Hyperactivity
Genes
Endophenotypes
Latin America
Sample Size
Population
Polymerase Chain Reaction
Research

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@article{e55c41cec3a540de9343555cc3a368fa,
title = "Lack of association of polymorphisms in six candidate genes in colombian adhd patients",
abstract = "Background: Attention Deficit and Hyperactivity Disorder (ADHD) is a common childhood neuropsychiatriccondition. The disorder has a multifactorial background, with heritability estimates of around 76{\%}, suggestingan important role of genetic factors. Candidate genes include those related to dopaminergic (e.g.DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways.Purpose: To explore the association of common polymorphisms in six genes (DRD4, DRD5, SLC6A3, DBH,HTR1B and SLC6A4) and the susceptibility to ADHD in a Colombian sample population.Methods: Eighty-six ADHD trios and 152 healthy controls were recruited. Genotyping of the six polymorphismswas performed using described PCR-based protocols. A TDT analysis was used to test if there waspreferential allelic transmission for any of the six polymorphisms. Additionally, a case-control analysis wasperformed to test for association of the serotoninergic (HTR1B and SLC6A4) polymorphisms with ADHD.Results: Through the TDT analysis there was no preferential allelic transmission for any of the studied variants.Case-control analysis did not show association.Conclusion: This is the first study in Latin America to describe six polymorphisms in a group of patientswith ADHD. There was no evidence of association for any of the studied polymorphic variants in this ColombianADHD sample. Further research, with larger sample sizes and study of endophenotypes, is neededin this population to confirm and extend the results",
author = "{Talero Gutierrez}, Claudia and {Fonseca Mendoza}, {Dora Janeth} and Mateus, {Heidi E} and G{\'a}lvez, {Jubby M} and Diego Forero and {Velez Van Meerbeke}, {Alberto Francisco}",
year = "2015",
month = "10",
day = "16",
doi = "10.5214/ans.0972.7531.220405",
language = "English (US)",
volume = "22",
pages = "217--221",
journal = "Annals of Neurosciences",
issn = "0972-7531",
publisher = "Indian Academy of Neurosciences",
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}

Lack of association of polymorphisms in six candidate genes in colombian adhd patients. / Talero Gutierrez, Claudia; Fonseca Mendoza, Dora Janeth; Mateus, Heidi E; Gálvez, Jubby M; Forero, Diego; Velez Van Meerbeke, Alberto Francisco.

En: Annals of Neurosciences, Vol. 22, N.º 4, 16.10.2015, p. 217-221.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Lack of association of polymorphisms in six candidate genes in colombian adhd patients

AU - Talero Gutierrez, Claudia

AU - Fonseca Mendoza, Dora Janeth

AU - Mateus, Heidi E

AU - Gálvez, Jubby M

AU - Forero, Diego

AU - Velez Van Meerbeke, Alberto Francisco

PY - 2015/10/16

Y1 - 2015/10/16

N2 - Background: Attention Deficit and Hyperactivity Disorder (ADHD) is a common childhood neuropsychiatriccondition. The disorder has a multifactorial background, with heritability estimates of around 76%, suggestingan important role of genetic factors. Candidate genes include those related to dopaminergic (e.g.DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways.Purpose: To explore the association of common polymorphisms in six genes (DRD4, DRD5, SLC6A3, DBH,HTR1B and SLC6A4) and the susceptibility to ADHD in a Colombian sample population.Methods: Eighty-six ADHD trios and 152 healthy controls were recruited. Genotyping of the six polymorphismswas performed using described PCR-based protocols. A TDT analysis was used to test if there waspreferential allelic transmission for any of the six polymorphisms. Additionally, a case-control analysis wasperformed to test for association of the serotoninergic (HTR1B and SLC6A4) polymorphisms with ADHD.Results: Through the TDT analysis there was no preferential allelic transmission for any of the studied variants.Case-control analysis did not show association.Conclusion: This is the first study in Latin America to describe six polymorphisms in a group of patientswith ADHD. There was no evidence of association for any of the studied polymorphic variants in this ColombianADHD sample. Further research, with larger sample sizes and study of endophenotypes, is neededin this population to confirm and extend the results

AB - Background: Attention Deficit and Hyperactivity Disorder (ADHD) is a common childhood neuropsychiatriccondition. The disorder has a multifactorial background, with heritability estimates of around 76%, suggestingan important role of genetic factors. Candidate genes include those related to dopaminergic (e.g.DRD4, DRD5, SLC6A3 and DBH)and serotoninergic (e.g.HTR1B and SLC6A4) pathways.Purpose: To explore the association of common polymorphisms in six genes (DRD4, DRD5, SLC6A3, DBH,HTR1B and SLC6A4) and the susceptibility to ADHD in a Colombian sample population.Methods: Eighty-six ADHD trios and 152 healthy controls were recruited. Genotyping of the six polymorphismswas performed using described PCR-based protocols. A TDT analysis was used to test if there waspreferential allelic transmission for any of the six polymorphisms. Additionally, a case-control analysis wasperformed to test for association of the serotoninergic (HTR1B and SLC6A4) polymorphisms with ADHD.Results: Through the TDT analysis there was no preferential allelic transmission for any of the studied variants.Case-control analysis did not show association.Conclusion: This is the first study in Latin America to describe six polymorphisms in a group of patientswith ADHD. There was no evidence of association for any of the studied polymorphic variants in this ColombianADHD sample. Further research, with larger sample sizes and study of endophenotypes, is neededin this population to confirm and extend the results

U2 - 10.5214/ans.0972.7531.220405

DO - 10.5214/ans.0972.7531.220405

M3 - Article

VL - 22

SP - 217

EP - 221

JO - Annals of Neurosciences

JF - Annals of Neurosciences

SN - 0972-7531

IS - 4

ER -