Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population

A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women

Título traducido de la contribución: La fuerza muscular como predictor de la mortalidad por todas las causas en una población aparentemente sana: Una revisión sistemática y meta-análisis de los datos de aproximadamente 2 millones de hombres y mujeres

Antonio García-Hermoso, Iván Cavero-Redondo, Robinson Ramírez-Vélez, Jonatan R. Ruiz, Francisco B. Ortega, Duck Chul Lee, Vicente Martínez-Vizcaíno

    Resultado de la investigación: Contribución a RevistaArtículo de revisión

    26 Citas (Scopus)

    Resumen

    OBJETIVOS: Los objetivos de la presente revisión sistemática y el metanálisis fueron determinar la relación entre la fuerza muscular y el riesgo de mortalidad por todas las causas y examinar la repercusión específica del sexo de la fuerza muscular sobre la mortalidad por todas las causas en una población aparentemente sana. FUENTES DE DATOS: Dos autores realizaron búsquedas sistemáticas en las bases de datos MEDLINE, EMBASE y SPORTDiscus y realizaron búsquedas manuales en las listas de referencias de los artículos seleccionados. SELECCIÓN DE ESTUDIOS: Los estudios de cohortes elegibles fueron aquellos que examinaron la asociación de la fuerza muscular con la mortalidad por todas las causas en una población aparentemente sana. Las estimaciones del cociente de riesgos (CR) con un intervalo de confianza (IC) del 95% se agruparon mediante el uso de modelos de metanálisis de efectos aleatorios después de evaluar la heterogeneidad entre los estudios. EXTRACCIÓN DE DATOS: Dos autores extrajeron los datos de forma independiente. SÍNTESIS DE DATOS: Se incluyeron en el metanálisis 38 estudios con 1 907 580 participantes. Los estudios incluidos tuvieron un total de 63 087 muertes. Los niveles más altos de fuerza de la empuñadura se asociaron con un menor riesgo de mortalidad por todas las causas (CRI = 0,69; IC del 95%: 0,64 a 0,74) en comparación con una menor fuerza muscular, con una asociación ligeramente más fuerte en las mujeres (CRI = 0,60; IC del 95%: 0,51 a 0,69) que en los hombres (CRI = 0,69; IC del 95%: 0,62 a 0,77) (todos ellos P<0,001). Además, los adultos con mayores niveles de fuerza muscular, evaluados mediante la prueba de fuerza de extensión de rodilla, tuvieron un riesgo de muerte un 14% menor (CRI = 0,86; IC del 95%: 0,80 a 0,93; p < 0,001) en comparación con los adultos con menor fuerza muscular. CONCLUSIONES: Los niveles más altos de fuerza muscular en la parte superior e inferior del cuerpo se asocian con un menor riesgo de mortalidad en la población adulta, independientemente de la edad y el período de seguimiento. Las pruebas de fuerza muscular se pueden realizar fácilmente para identificar a las personas con menor fuerza muscular y, en consecuencia, con un mayor riesgo de mortalidad.
    Idioma originalEnglish (US)
    Páginas (desde-hasta)2100-2113.e5
    PublicaciónArchives of Physical Medicine and Rehabilitation
    Volumen99
    N.º10
    DOI
    EstadoPublished - oct 1 2018

    All Science Journal Classification (ASJC) codes

    • Physical Therapy, Sports Therapy and Rehabilitation
    • Rehabilitation

    Citar esto

    García-Hermoso, Antonio ; Cavero-Redondo, Iván ; Ramírez-Vélez, Robinson ; Ruiz, Jonatan R. ; Ortega, Francisco B. ; Lee, Duck Chul ; Martínez-Vizcaíno, Vicente. / Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population : A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women. En: Archives of Physical Medicine and Rehabilitation. 2018 ; Vol. 99, N.º 10. pp. 2100-2113.e5.
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    title = "Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population: A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women",
    abstract = "Objectives: The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. Data Sources: Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection: Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in an apparently healthy population. The hazard ratio (HR) estimates with 95{\%} confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies. Data Extraction: Two authors independently extracted data. Data Synthesis: Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR=0.69; 95{\%} CI, 0.64-0.74) compared with lower muscular strength, with a slightly stronger association in women (HR=0.60; 95{\%} CI, 0.51-0.69) than men (HR=0.69; 95{\%} CI, 0.62-0.77) (all P<.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14{\%} lower risk of death (HR=0.86: 95{\%} CI, 0.80-0.93; P<.001) compared with adults with lower muscular strength. Conclusions: Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of age and follow-up period. Muscular strength tests can be easily performed to identify people with lower muscular strength and, consequently, with an increased risk of mortality.",
    author = "Antonio Garc{\'i}a-Hermoso and Iv{\'a}n Cavero-Redondo and Robinson Ram{\'i}rez-V{\'e}lez and Ruiz, {Jonatan R.} and Ortega, {Francisco B.} and Lee, {Duck Chul} and Vicente Mart{\'i}nez-Vizca{\'i}no",
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    language = "English (US)",
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    Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population : A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women. / García-Hermoso, Antonio; Cavero-Redondo, Iván; Ramírez-Vélez, Robinson; Ruiz, Jonatan R.; Ortega, Francisco B.; Lee, Duck Chul; Martínez-Vizcaíno, Vicente.

    En: Archives of Physical Medicine and Rehabilitation, Vol. 99, N.º 10, 01.10.2018, p. 2100-2113.e5.

    Resultado de la investigación: Contribución a RevistaArtículo de revisión

    TY - JOUR

    T1 - Muscular Strength as a Predictor of All-Cause Mortality in an Apparently Healthy Population

    T2 - A Systematic Review and Meta-Analysis of Data From Approximately 2 Million Men and Women

    AU - García-Hermoso, Antonio

    AU - Cavero-Redondo, Iván

    AU - Ramírez-Vélez, Robinson

    AU - Ruiz, Jonatan R.

    AU - Ortega, Francisco B.

    AU - Lee, Duck Chul

    AU - Martínez-Vizcaíno, Vicente

    PY - 2018/10/1

    Y1 - 2018/10/1

    N2 - Objectives: The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. Data Sources: Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection: Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in an apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies. Data Extraction: Two authors independently extracted data. Data Synthesis: Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR=0.69; 95% CI, 0.64-0.74) compared with lower muscular strength, with a slightly stronger association in women (HR=0.60; 95% CI, 0.51-0.69) than men (HR=0.69; 95% CI, 0.62-0.77) (all P<.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR=0.86: 95% CI, 0.80-0.93; P<.001) compared with adults with lower muscular strength. Conclusions: Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of age and follow-up period. Muscular strength tests can be easily performed to identify people with lower muscular strength and, consequently, with an increased risk of mortality.

    AB - Objectives: The aims of the present systematic review and meta-analysis were to determine the relationship between muscular strength and all-cause mortality risk and to examine the sex-specific impact of muscular strength on all-cause mortality in an apparently healthy population. Data Sources: Two authors systematically searched MEDLINE, EMBASE and SPORTDiscus databases and conducted manual searching of reference lists of selected articles. Study Selection: Eligible cohort studies were those that examined the association of muscular strength with all-cause mortality in an apparently healthy population. The hazard ratio (HR) estimates with 95% confidence interval (CI) were pooled by using random effects meta-analysis models after assessing heterogeneity across studies. Data Extraction: Two authors independently extracted data. Data Synthesis: Thirty-eight studies with 1,907,580 participants were included in the meta-analysis. The included studies had a total of 63,087 deaths. Higher levels of handgrip strength were associated with a reduced risk of all-cause mortality (HR=0.69; 95% CI, 0.64-0.74) compared with lower muscular strength, with a slightly stronger association in women (HR=0.60; 95% CI, 0.51-0.69) than men (HR=0.69; 95% CI, 0.62-0.77) (all P<.001). Also, adults with higher levels of muscular strength, as assessed by knee extension strength test, had a 14% lower risk of death (HR=0.86: 95% CI, 0.80-0.93; P<.001) compared with adults with lower muscular strength. Conclusions: Higher levels of upper- and lower-body muscular strength are associated with a lower risk of mortality in adult population, regardless of age and follow-up period. Muscular strength tests can be easily performed to identify people with lower muscular strength and, consequently, with an increased risk of mortality.

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