Juvenile polyautoimmunity in a rheumatology setting

Clara Malagón, Maria del Pilar Gomez, Catalina Mosquera, Camilo Vargas, Tatiana Gonzalez, Cristine Arango, Lorena Martin, Pilar Perez, Laura Amaya-Uribe, Nicolas Molano-Gonzalez, Juan Manuel Anaya

Resultado de la investigación: Contribución a una revistaArtículo de revisión

2 Citas (Scopus)

Resumen

Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44%) patients. Multiple autoimmune syndrome was observed in 62 (19.8%) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8%), juvenile idiopathic arthritis (JIA, n = 40, 12.7%), Hashimoto's thyroiditis (HT, n = 24, 7.66%), immune thrombocytopenic purpura (ITP n = 20, 6.39%), antiphospholipid syndrome (APS, n = 15, 4.79%), and vitiligo (VIT, n = 15, 4.79%) were the most frequent and represented 79.23% of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (λ r = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sjögren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA.

Idioma originalInglés estadounidense
Páginas (desde-hasta)369-381
Número de páginas13
PublicaciónAutoimmunity Reviews
Volumen18
N.º4
DOI
EstadoPublicada - abr 1 2019

All Science Journal Classification (ASJC) codes

  • Inmulogía y alergología
  • Inmunología

Citar esto

Malagón, C., Gomez, M. D. P., Mosquera, C., Vargas, C., Gonzalez, T., Arango, C., ... Anaya, J. M. (2019). Juvenile polyautoimmunity in a rheumatology setting. Autoimmunity Reviews, 18(4), 369-381. https://doi.org/10.1016/j.autrev.2018.11.006
Malagón, Clara ; Gomez, Maria del Pilar ; Mosquera, Catalina ; Vargas, Camilo ; Gonzalez, Tatiana ; Arango, Cristine ; Martin, Lorena ; Perez, Pilar ; Amaya-Uribe, Laura ; Molano-Gonzalez, Nicolas ; Anaya, Juan Manuel. / Juvenile polyautoimmunity in a rheumatology setting. En: Autoimmunity Reviews. 2019 ; Vol. 18, N.º 4. pp. 369-381.
@article{1065f4fc35bc4654a313a1cb30d6dc13,
title = "Juvenile polyautoimmunity in a rheumatology setting",
abstract = "Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44{\%}) patients. Multiple autoimmune syndrome was observed in 62 (19.8{\%}) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8{\%}), juvenile idiopathic arthritis (JIA, n = 40, 12.7{\%}), Hashimoto's thyroiditis (HT, n = 24, 7.66{\%}), immune thrombocytopenic purpura (ITP n = 20, 6.39{\%}), antiphospholipid syndrome (APS, n = 15, 4.79{\%}), and vitiligo (VIT, n = 15, 4.79{\%}) were the most frequent and represented 79.23{\%} of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (λ r = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sj{\"o}gren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA.",
author = "Clara Malag{\'o}n and Gomez, {Maria del Pilar} and Catalina Mosquera and Camilo Vargas and Tatiana Gonzalez and Cristine Arango and Lorena Martin and Pilar Perez and Laura Amaya-Uribe and Nicolas Molano-Gonzalez and Anaya, {Juan Manuel}",
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Malagón, C, Gomez, MDP, Mosquera, C, Vargas, C, Gonzalez, T, Arango, C, Martin, L, Perez, P, Amaya-Uribe, L, Molano-Gonzalez, N & Anaya, JM 2019, 'Juvenile polyautoimmunity in a rheumatology setting', Autoimmunity Reviews, vol. 18, n.º 4, pp. 369-381. https://doi.org/10.1016/j.autrev.2018.11.006

Juvenile polyautoimmunity in a rheumatology setting. / Malagón, Clara; Gomez, Maria del Pilar; Mosquera, Catalina; Vargas, Camilo; Gonzalez, Tatiana; Arango, Cristine; Martin, Lorena; Perez, Pilar; Amaya-Uribe, Laura; Molano-Gonzalez, Nicolas; Anaya, Juan Manuel.

En: Autoimmunity Reviews, Vol. 18, N.º 4, 01.04.2019, p. 369-381.

Resultado de la investigación: Contribución a una revistaArtículo de revisión

TY - JOUR

T1 - Juvenile polyautoimmunity in a rheumatology setting

AU - Malagón, Clara

AU - Gomez, Maria del Pilar

AU - Mosquera, Catalina

AU - Vargas, Camilo

AU - Gonzalez, Tatiana

AU - Arango, Cristine

AU - Martin, Lorena

AU - Perez, Pilar

AU - Amaya-Uribe, Laura

AU - Molano-Gonzalez, Nicolas

AU - Anaya, Juan Manuel

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44%) patients. Multiple autoimmune syndrome was observed in 62 (19.8%) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8%), juvenile idiopathic arthritis (JIA, n = 40, 12.7%), Hashimoto's thyroiditis (HT, n = 24, 7.66%), immune thrombocytopenic purpura (ITP n = 20, 6.39%), antiphospholipid syndrome (APS, n = 15, 4.79%), and vitiligo (VIT, n = 15, 4.79%) were the most frequent and represented 79.23% of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (λ r = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sjögren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA.

AB - Overt polyautoimmunity (PolyA) corresponds to the presence of more than one well-defined autoimmune disease (AD) manifested clinically in a single patient. The current study aimed to describe the main characteristics of juvenile PolyA in a pediatric rheumatology setting and analyze the chronological aspects, index cases, familial autoimmunity, and clustering pattern. This was a cross-sectional and multicenter study in which 313 children with overt PolyA were included. Patients were systematically interviewed and their medical records reviewed using a questionnaire that sought information about demographic, clinical, immunological, and familial characteristics. A hierarchical cluster analysis was done to determine similarities between autoimmune diseases based on PolyA. PolyA occurred simultaneously in 138 (44%) patients. Multiple autoimmune syndrome was observed in 62 (19.8%) patients. There were 25 index diseases of which, systemic lupus erythematosus (SLE, n = 134, 42.8%), juvenile idiopathic arthritis (JIA, n = 40, 12.7%), Hashimoto's thyroiditis (HT, n = 24, 7.66%), immune thrombocytopenic purpura (ITP n = 20, 6.39%), antiphospholipid syndrome (APS, n = 15, 4.79%), and vitiligo (VIT, n = 15, 4.79%) were the most frequent and represented 79.23% of the total number of patients. Familial autoimmunity influenced PolyA. A high aggregation of autoimmunity was observed (λ r = 3.5). Three main clusters were identified, of which SLE and APS were the most similar pair of diseases (based on the Jaccard index) followed by HT and JIA, which were related to ITP and Sjögren's syndrome. The third cluster was composed of localized scleroderma and VIT. Our findings may assist physicians to make an early diagnosis of this frequent condition. Pediatric patients with ADs should be systematically assessed for PolyA.

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Malagón C, Gomez MDP, Mosquera C, Vargas C, Gonzalez T, Arango C y otros. Juvenile polyautoimmunity in a rheumatology setting. Autoimmunity Reviews. 2019 abr 1;18(4):369-381. https://doi.org/10.1016/j.autrev.2018.11.006