TY - GEN
T1 - Is It Possible to Correlate Age Related Time-Dependent Micro Mechanical Properties of Cortical Bone and Its Physico-Chemical Data?
AU - Jaramillo-Isaza, Sebastián
AU - Mazeran, Pierre Emmanuel
AU - El-Kirat, Karim
AU - Ho Ba Tho, Marie Christine
N1 - Publisher Copyright:
© 2019, Springer Nature Switzerland AG.
PY - 2019
Y1 - 2019
N2 - Correlational models between mechanical and physico-chemical properties are of interest for bone modeling and numerical simulations of bone growth and remodeling. Therefore, the aim of this work was to determine if it is possible to correlate mechanical and physic-chemical properties of cortical bone. Micro-mechanical and physico-chemical data were assessed in a rat cortical bone life-span model including samples aged of 1, 4, 9, 12, 18 and 24 months old. Time-dependent mechanical properties at the micro scale including elasticity, viscous properties and hardness were determined using nanoindentation tests. Meanwhile, physico-chemical properties include tissue micro-porosity, mineral, phosphates, carbonates and collagen content were determined using specific techniques for each property. Then, both properties were correlated and the highest matched were used to propose correlational models using multivariable-linear regressions. These initial results show good determinant and correlation coefficients in high agreement with the experimental data. These results could provide new evidences of how physico-chemical properties affect the mechanical response of bone material.
AB - Correlational models between mechanical and physico-chemical properties are of interest for bone modeling and numerical simulations of bone growth and remodeling. Therefore, the aim of this work was to determine if it is possible to correlate mechanical and physic-chemical properties of cortical bone. Micro-mechanical and physico-chemical data were assessed in a rat cortical bone life-span model including samples aged of 1, 4, 9, 12, 18 and 24 months old. Time-dependent mechanical properties at the micro scale including elasticity, viscous properties and hardness were determined using nanoindentation tests. Meanwhile, physico-chemical properties include tissue micro-porosity, mineral, phosphates, carbonates and collagen content were determined using specific techniques for each property. Then, both properties were correlated and the highest matched were used to propose correlational models using multivariable-linear regressions. These initial results show good determinant and correlation coefficients in high agreement with the experimental data. These results could provide new evidences of how physico-chemical properties affect the mechanical response of bone material.
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U2 - 10.1007/978-3-030-31019-6_30
DO - 10.1007/978-3-030-31019-6_30
M3 - Conference contribution
AN - SCOPUS:85075654905
SN - 9783030310189
T3 - Communications in Computer and Information Science
SP - 345
EP - 356
BT - Applied Computer Sciences in Engineering - 6th Workshop on Engineering Applications, WEA 2019, Proceedings
A2 - Figueroa-García, Juan Carlos
A2 - Duarte-González, Mario
A2 - Jaramillo-Isaza, Sebastián
A2 - Orjuela-Cañon, Alvaro David
A2 - Díaz-Gutierrez, Yesid
PB - Springer
T2 - 6th Workshop on Engineering Applications, WEA 2019
Y2 - 16 October 2019 through 18 October 2019
ER -