Involvement of astrocytes in Alzheimer´s disease from a neuroinflammatory and oxidative stress perspective.

Rodrigo Esteban Gonzalez Reyes, Mauricio Orlando Nava Mesa, Karina Vargas-Sánchez, Daniel Ariza-Salamanca, Laura Mora-Muñoz

Resultado de la investigación: Contribución a RevistaArtículo de revisión

44 Citas (Scopus)

Resumen

Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the great importance of astrocytes in brain homeostasis they have become interesting targets for the study of AD. Changes in astrocyte function have been observed in brain tissue from individuals with AD, as well as in AD in vitro and in vivo animal models. Excessive neuroinflammation and oxidative stress are observed in AD and astrocytes seem to be involved in both.
Astrocytes participate in the inflammatory/immune responses of the CNS. The presence of amyloidbeta activates different cell receptors and intracellular signaling pathways, mainly the RAGE/NF-κB pathway, responsible for the transcription of pro-inflammatory cytokines and chemokines in astrocytes. The release of these pro-inflammatory agents may induce cellular damage or even stimulate production of amyloid-beta in astrocytes. Amyloid-beta induces the appearance of oxidative stress and production of ROS and RNS in astrocytes, affecting among others, intracellular calcium levels, NADPH oxidase, NF-κB signaling, glutamate uptake (increasing the risk for excitotoxicity) and mitochondrial function. In this paper, we will also discuss therapeutic measures highlighting the importance of astrocytes in AD pathology.
Idioma originalEnglish (US)
Páginas (desde-hasta)1-20
Número de páginas20
PublicaciónFrontiers in Molecular Neuroscience
Volumen10
DOI
EstadoPublished - dic 19 2017

Huella dactilar

Astrocytes
Alzheimer Disease
Oxidative Stress
Amyloid
NADPH Oxidase
Brain
Chemokines
Neurodegenerative Diseases
Glutamic Acid
Homeostasis
Animal Models
Pathology
Cytokines
Calcium

Citar esto

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title = "Involvement of astrocytes in Alzheimer´s disease from a neuroinflammatory and oxidative stress perspective.",
abstract = "Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the great importance of astrocytes in brain homeostasis they have become interesting targets for the study of AD. Changes in astrocyte function have been observed in brain tissue from individuals with AD, as well as in AD in vitro and in vivo animal models. Excessive neuroinflammation and oxidative stress are observed in AD and astrocytes seem to be involved in both.Astrocytes participate in the inflammatory/immune responses of the CNS. The presence of amyloidbeta activates different cell receptors and intracellular signaling pathways, mainly the RAGE/NF-κB pathway, responsible for the transcription of pro-inflammatory cytokines and chemokines in astrocytes. The release of these pro-inflammatory agents may induce cellular damage or even stimulate production of amyloid-beta in astrocytes. Amyloid-beta induces the appearance of oxidative stress and production of ROS and RNS in astrocytes, affecting among others, intracellular calcium levels, NADPH oxidase, NF-κB signaling, glutamate uptake (increasing the risk for excitotoxicity) and mitochondrial function. In this paper, we will also discuss therapeutic measures highlighting the importance of astrocytes in AD pathology.",
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Involvement of astrocytes in Alzheimer´s disease from a neuroinflammatory and oxidative stress perspective. / Gonzalez Reyes, Rodrigo Esteban; Nava Mesa, Mauricio Orlando; Vargas-Sánchez, Karina; Ariza-Salamanca, Daniel; Mora-Muñoz, Laura.

En: Frontiers in Molecular Neuroscience, Vol. 10, 19.12.2017, p. 1-20.

Resultado de la investigación: Contribución a RevistaArtículo de revisión

TY - JOUR

T1 - Involvement of astrocytes in Alzheimer´s disease from a neuroinflammatory and oxidative stress perspective.

AU - Gonzalez Reyes, Rodrigo Esteban

AU - Nava Mesa, Mauricio Orlando

AU - Vargas-Sánchez, Karina

AU - Ariza-Salamanca, Daniel

AU - Mora-Muñoz, Laura

PY - 2017/12/19

Y1 - 2017/12/19

N2 - Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the great importance of astrocytes in brain homeostasis they have become interesting targets for the study of AD. Changes in astrocyte function have been observed in brain tissue from individuals with AD, as well as in AD in vitro and in vivo animal models. Excessive neuroinflammation and oxidative stress are observed in AD and astrocytes seem to be involved in both.Astrocytes participate in the inflammatory/immune responses of the CNS. The presence of amyloidbeta activates different cell receptors and intracellular signaling pathways, mainly the RAGE/NF-κB pathway, responsible for the transcription of pro-inflammatory cytokines and chemokines in astrocytes. The release of these pro-inflammatory agents may induce cellular damage or even stimulate production of amyloid-beta in astrocytes. Amyloid-beta induces the appearance of oxidative stress and production of ROS and RNS in astrocytes, affecting among others, intracellular calcium levels, NADPH oxidase, NF-κB signaling, glutamate uptake (increasing the risk for excitotoxicity) and mitochondrial function. In this paper, we will also discuss therapeutic measures highlighting the importance of astrocytes in AD pathology.

AB - Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed. Although many explicative theories have been proposed, precise pathophysiological mechanisms are unknown. Due to the great importance of astrocytes in brain homeostasis they have become interesting targets for the study of AD. Changes in astrocyte function have been observed in brain tissue from individuals with AD, as well as in AD in vitro and in vivo animal models. Excessive neuroinflammation and oxidative stress are observed in AD and astrocytes seem to be involved in both.Astrocytes participate in the inflammatory/immune responses of the CNS. The presence of amyloidbeta activates different cell receptors and intracellular signaling pathways, mainly the RAGE/NF-κB pathway, responsible for the transcription of pro-inflammatory cytokines and chemokines in astrocytes. The release of these pro-inflammatory agents may induce cellular damage or even stimulate production of amyloid-beta in astrocytes. Amyloid-beta induces the appearance of oxidative stress and production of ROS and RNS in astrocytes, affecting among others, intracellular calcium levels, NADPH oxidase, NF-κB signaling, glutamate uptake (increasing the risk for excitotoxicity) and mitochondrial function. In this paper, we will also discuss therapeutic measures highlighting the importance of astrocytes in AD pathology.

U2 - 10.3389/fnmol.2017.00427

DO - 10.3389/fnmol.2017.00427

M3 - Review article

VL - 10

SP - 1

EP - 20

JO - Frontiers in Molecular Neuroscience

JF - Frontiers in Molecular Neuroscience

SN - 1662-5099

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