Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review

Luisa Fernanda Garciá Salazar; Gabriela Lopes Dos Santos; Silvia Letícia Pavaõ; Nelci Adriana Cicuto Ferreira Rocha; Thiago Luiz De Russo

doi:10.3109/17518423.2014.948640

Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review

Título traducido de la contribución: Propiedades intrínsecas y cambios funcionales en el músculo espástico tras la aplicación de BTX-A en niños con parálisis cerebral: Revisión sistemática

Luisa Fernanda Garciá Salazar, Gabriela Lopes Dos Santos, Silvia Letícia Pavaõ, Nelci Adriana Cicuto Ferreira Rocha, Thiago Luiz De Russo

Escuela de Medicina y Ciencias de la Salud

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

13 Citas (Scopus)

Resumen

Objetivo: Este artículo tuvo como objetivo revisar la literatura para verificar el efecto de la toxina botulínica tipo A (BTX-A) sobre las propiedades intrínsecas de los músculos espásticos y la funcionalidad en niños con parálisis cerebral (PC). Métodos: Se realizó una búsqueda bibliográfica en las siguientes bases de datos: CINAHL, SCOPUS, Web of Science y PubMed. Las búsquedas en las bases de datos se limitaron al periodo comprendido entre enero de 1993 y marzo de 2014. Resultados: Se identificaron un total de 2182 artículos, y 17 cumplieron los criterios de inclusión. Sólo un estudio analizó el efecto de la toxina sobre las propiedades intrínsecas del músculo y otros analizaron el efecto sobre la funcionalidad. Conclusiones: La aplicación de BTX-A no demostró cambios en la rigidez pasiva del músculo espástico. En relación al nivel funcional, la evidencia del efecto de BTX-A fue controvertida. Estos estudios mostraron limitaciones de calidad metodológica que restringen la interpretación de los resultados para toda la población con PC, lo que justifica la necesidad de realizar más ensayos controlados aleatorizados.

Título traducido de la contribución	Propiedades intrínsecas y cambios funcionales en el músculo espástico tras la aplicación de BTX-A en niños con parálisis cerebral: Revisión sistemática
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	1-14
Número de páginas	14
Publicación	Developmental Neurorehabilitation
Volumen	18
N.º	1
DOI	https://doi.org/10.3109/17518423.2014.948640
Estado	Publicada - feb. 1 2015

Áreas temáticas de ASJC Scopus

Pediatría, perinaltología y salud infantil
Rehabilitación
Neurociencia evolutiva

ODS de las Naciones Unidas

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title = "Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review",

abstract = "Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.",

author = "{Garci{\'a} Salazar}, {Luisa Fernanda} and Santos, {Gabriela Lopes Dos} and Pava{\~o}, {Silvia Let{\'i}cia} and Rocha, {Nelci Adriana Cicuto Ferreira} and Russo, {Thiago Luiz De}",

note = "Funding Information: The authors want to thank the fellowship provided by the Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico CNPq. L.F.G.S. was master student supported by Programa Estudantes-Conv{\^e}nio de P{\'o}s-Graduac¸{\~a}o – PEC-PG, da CAPES/CNPq – Brazil. Publisher Copyright: {\textcopyright} 2015 Informa UK Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

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doi = "10.3109/17518423.2014.948640",

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Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review. / Garciá Salazar, Luisa Fernanda; Santos, Gabriela Lopes Dos; Pavaõ, Silvia Letícia et al.
En: Developmental Neurorehabilitation, Vol. 18, N.º 1, 01.02.2015, p. 1-14.

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

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AU - Garciá Salazar, Luisa Fernanda

AU - Santos, Gabriela Lopes Dos

AU - Pavaõ, Silvia Letícia

AU - Rocha, Nelci Adriana Cicuto Ferreira

AU - Russo, Thiago Luiz De

N1 - Funding Information: The authors want to thank the fellowship provided by the Conselho Nacional de Desenvolvimento Científico e Tecnológico CNPq. L.F.G.S. was master student supported by Programa Estudantes-Convênio de Pós-Graduac¸ão – PEC-PG, da CAPES/CNPq – Brazil. Publisher Copyright: © 2015 Informa UK Ltd. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.

AB - Objective: This article aimed to review the literature to verify the effect of botulinum toxin type A (BTX-A) on the intrinsic properties of spastic muscles and functionality in children with cerebral palsy (CP). Methods: A literature search was conducted in the following databases: CINAHL, SCOPUS, Web of Science and PubMed. Database searches were limited to the period from January 1993 to March 2014. Results: A total of 2182 papers were identified, and 17 met the inclusion criteria. Only one study analyzed the effect of the toxin on muscle intrinsic properties and others analyzed the effect on functionality. Conclusion: BTX-A application demonstrated no changes in the passive stiffness of spastic muscle. In relation to functional level, the evidence of BTX-A effect was controversial. These studies showed methodological quality limitations that restrict the interpretation of the results for the entire CP population, which justifies the need for further randomized controlled trials.

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Intrinsic properties and functional changes in spastic muscle after application of BTX-A in children with cerebral palsy: Systematic review

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