Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design

Luis Eduardo Rodriguez, Hernando Curtidor, Mauricio Urquiza, Gladys Cifuentes, Claudia Reyes, Manuel Elkin Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

73 Citas (Scopus)

Resumen

A first step in the development of a logical and rational methodology for obtaining vaccines against the threatening effects of malaria has been a thorough analysis of the intimate molecular interactions of the molecules involved in P. falciparum's invasion of red blood cells (RBC) including secondary and 3D structure determination of some of them. Blocking the interactions could specifically be induced by activating the immune system with these molecules. Developing a completely effective vaccine against the parasite's blood stage must therefore involve a similar number of conserved high-activity bending peptides (HABPs) derived from some of the proteins that are directly involved in RBC invasion being blocked by the immune system. Data on the number of HABPs, their presence, processed and released fragments, network interactions, and merozoite-membrane-rafts shows the complexity of the processes involved in merozoite invasion of RBCs.

Idioma originalEnglish (US)
Páginas (desde-hasta)3656-3705
Número de páginas50
PublicaciónChemical Reviews
Volumen108
N.º9
DOI
EstadoPublished - sep 1 2008

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Citar esto

Rodriguez, Luis Eduardo ; Curtidor, Hernando ; Urquiza, Mauricio ; Cifuentes, Gladys ; Reyes, Claudia ; Patarroyo, Manuel Elkin. / Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design. En: Chemical Reviews. 2008 ; Vol. 108, N.º 9. pp. 3656-3705.
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Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design. / Rodriguez, Luis Eduardo; Curtidor, Hernando; Urquiza, Mauricio; Cifuentes, Gladys; Reyes, Claudia; Patarroyo, Manuel Elkin.

En: Chemical Reviews, Vol. 108, N.º 9, 01.09.2008, p. 3656-3705.

Resultado de la investigación: Contribución a RevistaArtículo

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AU - Rodriguez, Luis Eduardo

AU - Curtidor, Hernando

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AU - Reyes, Claudia

AU - Patarroyo, Manuel Elkin

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