Interspecific resources: a major tool for quantitative trait locus cloning and speciation research

Paul Laissue Hormaza, David L'Hôte, Catherine Serres, Xavier Montagutelli, Reiner A. Veitia, Daniel Vaiman

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

16 Citas (Scopus)

Resumen

Positional cloning of the quantitative trait locus (QTL) still encounters numerous difficulties, which explains why thousands of QTL have been mapped, while only a few have been identified at the molecular level. Here, we focus on a specific mapping tool that exists in plant and animal model species: interspecific recombinant congenic strains (IRCSs) or interspecific nearly isogenic lines (NILs). Such panels exhibit a much higher sequence diversity than intraspecific sets, thus enhancing the contrasts between phenotypes. In animals, it allows statistical significance to be reached even when using a limited number of individuals. Therefore, we argue that interspecific resources may constitute a major genetic tool for positional cloning and for understanding some bases of speciation mechanisms.
Idioma originalInglés estadounidense
Páginas (desde-hasta)132-142
Número de páginas11
PublicaciónBioEssays
Volumen32
N.º2
DOI
EstadoPublicada - ene 20 2010

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