Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia

Manuel Medina; Sara Zuluaga; María Fernanda Martínez; Juan Carlos Bermúdez; Carolina Hernández; Virgilio Beltrán; Natalia Velásquez-Ortiz; Marina Muñoz; Juan David Ramírez; Omar Triana; Omar Cantillo-Barraza

doi:10.3389/fcimb.2022.998202

Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia

Título traducido de la contribución: Interrogando la dinámica de transmisión de Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) por Triatoma venosa (Hemiptera: Reduviidae) luego de la eliminación de la transmisión vectorial por Rhodnius prolixus en Boyacá oriente de Colombia

Manuel Medina, Sara Zuluaga, María Fernanda Martínez, Juan Carlos Bermúdez, Carolina Hernández, Virgilio Beltrán, Natalia Velásquez-Ortiz, Marina Muñoz, Juan David Ramírez, Omar Triana, Omar Cantillo-Barraza

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3 Citas (Scopus)

Resumen

La enfermedad de Chagas (EC) es una zoonosis parasitaria ( trypanosoma cruzi) endémica en Colombia. Control vectorial de Rhodnius prolixus , el principal T. cruzi domésticovector, se ha logrado en gran parte de la zona con transmisión históricamente vectorial de CD. Es necesario comprender las características del comportamiento ecológico de los vectores nativos locales para garantizar la sostenibilidad de los programas de control de vectores. Para evaluar el éxito a largo plazo de una reciente campaña de control de vectores en el departamento de Boyacá (Colombia), utilizamos una estrategia combinada de vigilancia entomológica con vigilancia canina coexistente en diez aldeas rurales dentro de seis municipios de la región del valle de Tenza (Boyacá, Colombia): Chinavita, Garagoa, Guateque, Somondoco, Sutatenza y Tenza, con reportes históricos de R. prolixus y vectores secundarios. Se analizaron triatominos recolectados y sangre entera canina para detectar T. cruzi.Infección y genotipado. Se evaluaron especímenes de insectos triatominos para determinar su fuente de alimentación de sangre. La serología canina se realizó mediante dos ensayos de anticuerpos distintos. En total, se recolectaron 101 Triatoma venosa mediante búsqueda activa en hábitats domésticos y peridomésticos. Se identificó una prevalencia de infección natural del 13,9% (14/101) y cuatro fuentes de alimentación: humano, perro, rata y gallina. Se observó una frecuencia de infección del 46,5% (40/87) en dos pruebas serológicas independientes y se detectó ADN de T. cruzi en 14 perros (16,4%). Sólo se detectó DTU selvática TcI. Los resultados sugieren que T. venosa presenta características ecoepidemiológicas para mantener la transmisión de T. cruzien el valle de Tenza. Esta especie ha reinfestado los hogares intervenidos y tiene un papel activo en la transmisión doméstica y peridoméstica de T. cruzi debido a sus tasas de infección y comportamiento alimentario. Por lo tanto, esta especie debe considerarse epidemiológicamente relevante para las estrategias de control de vectores. Además, es necesario realizar estudios serológicos en humanos para conocer de cerca el riesgo al que están expuestos.

Título traducido de la contribución	Interrogando la dinámica de transmisión de Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) por Triatoma venosa (Hemiptera: Reduviidae) luego de la eliminación de la transmisión vectorial por Rhodnius prolixus en Boyacá oriente de Colombia
Idioma original	Inglés estadounidense
Número de artículo	998202
Publicación	Frontiers in cellular and infection microbiology
Volumen	12
DOI	https://doi.org/10.3389/fcimb.2022.998202
Estado	Publicada - oct. 6 2022

Áreas temáticas de ASJC Scopus

Microbiología
Inmunología
Microbiología (médica)
Enfermedades infecciosas

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

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Medina, M., Zuluaga, S., Martínez, M. F., Bermúdez, J. C., Hernández, C., Beltrán, V., Velásquez-Ortiz, N., Muñoz, M., Ramírez, J. D., Triana, O., & Cantillo-Barraza, O. (2022). Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia. Frontiers in cellular and infection microbiology, 12, Artículo 998202. https://doi.org/10.3389/fcimb.2022.998202

Medina, Manuel ; Zuluaga, Sara ; Martínez, María Fernanda et al. / Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia. En: Frontiers in cellular and infection microbiology. 2022 ; Vol. 12.

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title = "Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyac{\'a} eastern Colombia",

abstract = "Chagas disease (CD) is a parasitic zoonosis (Trypanosoma cruzi) that is endemic in Colombia. Vector control of Rhodnius prolixus, the main domestic T. cruzi vector, has been achieved in a large part of the area with historically vector transmission of CD. It is necessary to understand the ecological behavior characteristics of local native vectors to ensure sustainability of the vector control programs. To evaluate the long-term success of a recent vector control campaign in the Boyac{\'a} department (Colombia), we used a combined strategy of entomological surveillance with co-existing canine surveillance from ten rural villages within six municipalities of the Tenza valley region (Boyac{\'a}, Colombia): Chinavita, Garagoa, Guateque, Somondoco, Sutatenza and Tenza, with historical reports of R. prolixus and secondary vectors. Collected triatomines and canine whole blood were analyzed for T. cruzi infection and genotyping. Triatomine bugs specimens were evaluated for blood meal source. Canine serology was performed using two distinct antibody assays. In total, 101 Triatoma venosa were collected by active search in domestic and peridomestic habitats. A natural infection prevalence of 13.9% (14/101) and four feeding sources were identified: human, dog, rat, and hen. A frequency infection of 46.5% (40/87) was observed from two independent serological tests and T. cruzi DNA was detected in 14 dogs (16.4%). Only TcIsylvatic DTU was detected. The results suggest that T. venosa present eco-epidemiological characteristics to maintain the transmission of T. cruzi in Tenza valley. This species has reinfested the intervened households and it has an active role in domestic and peridomestic transmission of T. cruzi due to their infection rates and feeding behavior. Therefore, this species should be considered as epidemiologically relevant for vector control strategies. Moreover, there is a need for human serological studies to have a close up of risk they are exposed to.",

author = "Manuel Medina and Sara Zuluaga and Mart{\'i}nez, {Mar{\'i}a Fernanda} and Berm{\'u}dez, {Juan Carlos} and Carolina Hern{\'a}ndez and Virgilio Beltr{\'a}n and Natalia Vel{\'a}squez-Ortiz and Marina Mu{\~n}oz and Ram{\'i}rez, {Juan David} and Omar Triana and Omar Cantillo-Barraza",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Medina, Zuluaga, Mart{\'i}nez, Berm{\'u}dez, Hern{\'a}ndez, Beltr{\'a}n, Vel{\'a}squez-Ortiz, Mu{\~n}oz, Ram{\'i}rez, Triana and Cantillo-Barraza.",

year = "2022",

month = oct,

day = "6",

doi = "10.3389/fcimb.2022.998202",

language = "English (US)",

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journal = "Frontiers in cellular and infection microbiology",

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Medina, M, Zuluaga, S, Martínez, MF, Bermúdez, JC, Hernández, C, Beltrán, V, Velásquez-Ortiz, N, Muñoz, M, Ramírez, JD, Triana, O & Cantillo-Barraza, O 2022, 'Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia', Frontiers in cellular and infection microbiology, vol. 12, 998202. https://doi.org/10.3389/fcimb.2022.998202

Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia. / Medina, Manuel; Zuluaga, Sara; Martínez, María Fernanda et al.
En: Frontiers in cellular and infection microbiology, Vol. 12, 998202, 06.10.2022.

Producción científica: Contribución a una revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia

AU - Medina, Manuel

AU - Zuluaga, Sara

AU - Martínez, María Fernanda

AU - Bermúdez, Juan Carlos

AU - Hernández, Carolina

AU - Beltrán, Virgilio

AU - Velásquez-Ortiz, Natalia

AU - Muñoz, Marina

AU - Ramírez, Juan David

AU - Triana, Omar

AU - Cantillo-Barraza, Omar

PY - 2022/10/6

Y1 - 2022/10/6

N2 - Chagas disease (CD) is a parasitic zoonosis (Trypanosoma cruzi) that is endemic in Colombia. Vector control of Rhodnius prolixus, the main domestic T. cruzi vector, has been achieved in a large part of the area with historically vector transmission of CD. It is necessary to understand the ecological behavior characteristics of local native vectors to ensure sustainability of the vector control programs. To evaluate the long-term success of a recent vector control campaign in the Boyacá department (Colombia), we used a combined strategy of entomological surveillance with co-existing canine surveillance from ten rural villages within six municipalities of the Tenza valley region (Boyacá, Colombia): Chinavita, Garagoa, Guateque, Somondoco, Sutatenza and Tenza, with historical reports of R. prolixus and secondary vectors. Collected triatomines and canine whole blood were analyzed for T. cruzi infection and genotyping. Triatomine bugs specimens were evaluated for blood meal source. Canine serology was performed using two distinct antibody assays. In total, 101 Triatoma venosa were collected by active search in domestic and peridomestic habitats. A natural infection prevalence of 13.9% (14/101) and four feeding sources were identified: human, dog, rat, and hen. A frequency infection of 46.5% (40/87) was observed from two independent serological tests and T. cruzi DNA was detected in 14 dogs (16.4%). Only TcIsylvatic DTU was detected. The results suggest that T. venosa present eco-epidemiological characteristics to maintain the transmission of T. cruzi in Tenza valley. This species has reinfested the intervened households and it has an active role in domestic and peridomestic transmission of T. cruzi due to their infection rates and feeding behavior. Therefore, this species should be considered as epidemiologically relevant for vector control strategies. Moreover, there is a need for human serological studies to have a close up of risk they are exposed to.

AB - Chagas disease (CD) is a parasitic zoonosis (Trypanosoma cruzi) that is endemic in Colombia. Vector control of Rhodnius prolixus, the main domestic T. cruzi vector, has been achieved in a large part of the area with historically vector transmission of CD. It is necessary to understand the ecological behavior characteristics of local native vectors to ensure sustainability of the vector control programs. To evaluate the long-term success of a recent vector control campaign in the Boyacá department (Colombia), we used a combined strategy of entomological surveillance with co-existing canine surveillance from ten rural villages within six municipalities of the Tenza valley region (Boyacá, Colombia): Chinavita, Garagoa, Guateque, Somondoco, Sutatenza and Tenza, with historical reports of R. prolixus and secondary vectors. Collected triatomines and canine whole blood were analyzed for T. cruzi infection and genotyping. Triatomine bugs specimens were evaluated for blood meal source. Canine serology was performed using two distinct antibody assays. In total, 101 Triatoma venosa were collected by active search in domestic and peridomestic habitats. A natural infection prevalence of 13.9% (14/101) and four feeding sources were identified: human, dog, rat, and hen. A frequency infection of 46.5% (40/87) was observed from two independent serological tests and T. cruzi DNA was detected in 14 dogs (16.4%). Only TcIsylvatic DTU was detected. The results suggest that T. venosa present eco-epidemiological characteristics to maintain the transmission of T. cruzi in Tenza valley. This species has reinfested the intervened households and it has an active role in domestic and peridomestic transmission of T. cruzi due to their infection rates and feeding behavior. Therefore, this species should be considered as epidemiologically relevant for vector control strategies. Moreover, there is a need for human serological studies to have a close up of risk they are exposed to.

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Medina M, Zuluaga S, Martínez MF, Bermúdez JC, Hernández C, Beltrán V et al. Interrogating the transmission dynamics of Trypanosoma cruzi (Trypanosomatida, Trypanosomatidae) by Triatoma venosa (Hemiptera: Reduviidae) after the elimination of vector transmission by Rhodnius prolixus in Boyacá eastern Colombia. Frontiers in cellular and infection microbiology. 2022 oct. 6;12:998202. doi: 10.3389/fcimb.2022.998202