Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism

Juan Manuel Anaya, Paula A Correa, Mónica Herrera, Joyce Eskdale, Grant Gallagher

Resultado de la investigación: Contribución a libro /Tipo informe o reporteCapítulo

Resumen

OBJECTIVE: To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren's syndrome (pSS). METHODS: Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. RESULTS: IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 +/- 6.7 vs 2.5 +/- 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (<9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. CONCLUSION: Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.
Idioma originalEnglish (US)
Título de la publicación alojadaJournal of Rheumatology
Páginas1874-1876
Número de páginas3
EstadoPublished - sep 2002

Serie de la publicación

NombreJournal of Rheumatology
Volumen29

Huella dactilar

Autoimmunity
Interleukin-10
Genes
Salivary Gland Diseases
Rheumatoid Factor
Sjogren's Syndrome
Microsatellite Repeats
Autoantibodies
Immunoglobulin A
Minor Salivary Glands
Skin
Vasculitis
Serum
Anti-Idiotypic Antibodies
Enzyme-Linked Immunosorbent Assay
Alleles
Biopsy
Polymerase Chain Reaction

Citar esto

Anaya, J. M., Correa, P. A., Herrera, M., Eskdale, J., & Gallagher, G. (2002). Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism. En Journal of Rheumatology (pp. 1874-1876). (Journal of Rheumatology; Vol. 29).
Anaya, Juan Manuel ; Correa, Paula A ; Herrera, Mónica ; Eskdale, Joyce ; Gallagher, Grant. / Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism. Journal of Rheumatology. 2002. pp. 1874-1876 (Journal of Rheumatology).
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abstract = "OBJECTIVE: To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sj{\"o}gren's syndrome (pSS). METHODS: Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. RESULTS: IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 +/- 6.7 vs 2.5 +/- 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (<9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. CONCLUSION: Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.",
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Anaya, JM, Correa, PA, Herrera, M, Eskdale, J & Gallagher, G 2002, Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism. En Journal of Rheumatology. Journal of Rheumatology, vol. 29, pp. 1874-1876.

Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism. / Anaya, Juan Manuel; Correa, Paula A; Herrera, Mónica; Eskdale, Joyce; Gallagher, Grant.

Journal of Rheumatology. 2002. p. 1874-1876 (Journal of Rheumatology; Vol. 29).

Resultado de la investigación: Contribución a libro /Tipo informe o reporteCapítulo

TY - CHAP

T1 - Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism

AU - Anaya, Juan Manuel

AU - Correa, Paula A

AU - Herrera, Mónica

AU - Eskdale, Joyce

AU - Gallagher, Grant

PY - 2002/9

Y1 - 2002/9

N2 - OBJECTIVE: To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren's syndrome (pSS). METHODS: Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. RESULTS: IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 +/- 6.7 vs 2.5 +/- 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (<9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. CONCLUSION: Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.

AB - OBJECTIVE: To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren's syndrome (pSS). METHODS: Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. RESULTS: IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 +/- 6.7 vs 2.5 +/- 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (<9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. CONCLUSION: Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism.

M3 - Chapter

SN - 0315-162X (Print)\r0315-162X (Linking)

T3 - Journal of Rheumatology

SP - 1874

EP - 1876

BT - Journal of Rheumatology

ER -

Anaya JM, Correa PA, Herrera M, Eskdale J, Gallagher G. Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism. En Journal of Rheumatology. 2002. p. 1874-1876. (Journal of Rheumatology).