Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: Reversal by holotransferrin

L. E. Cano, B. Gomez, E. Brummer, A. Restrepo, D. A. Stevens

Resultado de la investigación: Contribución a una revistaComentario/Debaterevisión exhaustiva

30 Citas (Scopus)

Resumen

Conidia of P. brasiliensis ingested by murine macrophages at 37°C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells.

Idioma originalInglés estadounidense
Páginas (desde-hasta)1494-1496
Número de páginas3
PublicaciónInfection and Immunity
Volumen62
N.º4
EstadoPublicada - 1994
Publicado de forma externa

All Science Journal Classification (ASJC) codes

  • Parasitología
  • Microbiología
  • Inmunología
  • Enfermedades infecciosas

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