TY - JOUR
T1 - Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population
AU - Mamtani, Manju
AU - Mummidi, Srinivas
AU - Ramsuran, Veron
AU - Pham, Minh Hieu
AU - Maldonado, Robert
AU - Begum, Kazi
AU - Valera, Maria Soledad
AU - Sanchez, Racquel
AU - Castiblanco, John
AU - Kulkarni, Hemant
AU - Ndung'u, Thumbi
AU - He, Weijing
AU - Anaya, Juan Manuel
AU - Ahuja, Sunil K.
N1 - Funding Information:
This work was supported by the Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System, and the NIH (R37046326), a VA MERIT award, the Elizabeth Glaser Scientist Award, the Burroughs Wellcome Clinical Scientist Award in Translational Research, and the Doris Duke Distinguished Clinical Scientist Award to S. K. A. The work was also supported by a VA MERIT award to S. M.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.
AB - We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.
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U2 - 10.1093/infdis/jir145
DO - 10.1093/infdis/jir145
M3 - Research Article
C2 - 21592988
AN - SCOPUS:79956196408
SN - 0022-1899
VL - 203
SP - 1590
EP - 1594
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -
