Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

Manju Mamtani, Srinivas Mummidi, Veron Ramsuran, Minh Hieu Pham, Robert Maldonado, Kazi Begum, Maria Soledad Valera, Racquel Sanchez, John Castiblanco, Hemant Kulkarni, Thumbi Ndung'u, Weijing He, Juan Manuel Anaya, Sunil K. Ahuja

Resultado de la investigación: Contribución a RevistaArtículo

15 Citas (Scopus)

Resumen

We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)1590-1594
Número de páginas5
PublicaciónJournal of Infectious Diseases
DOI
EstadoPublished - jun 1 2011

Huella dactilar

Tuberculosis
Chemokine CCL3
Population
Acquired Immunodeficiency Syndrome
HIV
Ligands
Colombia
Chemokine Receptors
Chemokines
Haplotypes
HIV-1
Gene Expression

Citar esto

Mamtani, M., Mummidi, S., Ramsuran, V., Pham, M. H., Maldonado, R., Begum, K., ... Ahuja, S. K. (2011). Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population. Journal of Infectious Diseases, 1590-1594. https://doi.org/10.1093/infdis/jir145
Mamtani, Manju ; Mummidi, Srinivas ; Ramsuran, Veron ; Pham, Minh Hieu ; Maldonado, Robert ; Begum, Kazi ; Valera, Maria Soledad ; Sanchez, Racquel ; Castiblanco, John ; Kulkarni, Hemant ; Ndung'u, Thumbi ; He, Weijing ; Anaya, Juan Manuel ; Ahuja, Sunil K. / Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population. En: Journal of Infectious Diseases. 2011 ; pp. 1590-1594.
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abstract = "We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. {\circledC} The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.",
author = "Manju Mamtani and Srinivas Mummidi and Veron Ramsuran and Pham, {Minh Hieu} and Robert Maldonado and Kazi Begum and Valera, {Maria Soledad} and Racquel Sanchez and John Castiblanco and Hemant Kulkarni and Thumbi Ndung'u and Weijing He and Anaya, {Juan Manuel} and Ahuja, {Sunil K.}",
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Mamtani, M, Mummidi, S, Ramsuran, V, Pham, MH, Maldonado, R, Begum, K, Valera, MS, Sanchez, R, Castiblanco, J, Kulkarni, H, Ndung'u, T, He, W, Anaya, JM & Ahuja, SK 2011, 'Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population', Journal of Infectious Diseases, pp. 1590-1594. https://doi.org/10.1093/infdis/jir145

Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population. / Mamtani, Manju; Mummidi, Srinivas; Ramsuran, Veron; Pham, Minh Hieu; Maldonado, Robert; Begum, Kazi; Valera, Maria Soledad; Sanchez, Racquel; Castiblanco, John; Kulkarni, Hemant; Ndung'u, Thumbi; He, Weijing; Anaya, Juan Manuel; Ahuja, Sunil K.

En: Journal of Infectious Diseases, 01.06.2011, p. 1590-1594.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Influence of Variations in CCL3L1 and CCR5 on Tuberculosis in a Northwestern Colombian Population

AU - Mamtani, Manju

AU - Mummidi, Srinivas

AU - Ramsuran, Veron

AU - Pham, Minh Hieu

AU - Maldonado, Robert

AU - Begum, Kazi

AU - Valera, Maria Soledad

AU - Sanchez, Racquel

AU - Castiblanco, John

AU - Kulkarni, Hemant

AU - Ndung'u, Thumbi

AU - He, Weijing

AU - Anaya, Juan Manuel

AU - Ahuja, Sunil K.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

AB - We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the proinflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

U2 - 10.1093/infdis/jir145

DO - 10.1093/infdis/jir145

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JO - Journal of Infectious Diseases

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SN - 0022-1899

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