Influence of STAT4 polymorphism in primary Sjögren's syndrome

Rogelio J. Palomino-Morales, Lina Marcela Diaz-Gallo, Torsten Witte, Juan Manuel Anaya, Javier Martín

Resultado de la investigación: Contribución a RevistaArtículo

19 Citas (Scopus)

Resumen

Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95% CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright © 2010. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)1016-1019
Número de páginas4
PublicaciónJournal of Rheumatology
DOI
EstadoPublished - may 1 2010

Huella dactilar

Sjogren's Syndrome
Genes
Single Nucleotide Polymorphism
Colombia
Rheumatology
Gene Frequency
Germany
Alleles

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Palomino-Morales, R. J., Diaz-Gallo, L. M., Witte, T., Anaya, J. M., & Martín, J. (2010). Influence of STAT4 polymorphism in primary Sjögren's syndrome. Journal of Rheumatology, 1016-1019. https://doi.org/10.3899/jrheum.091007
Palomino-Morales, Rogelio J. ; Diaz-Gallo, Lina Marcela ; Witte, Torsten ; Anaya, Juan Manuel ; Martín, Javier. / Influence of STAT4 polymorphism in primary Sjögren's syndrome. En: Journal of Rheumatology. 2010 ; pp. 1016-1019.
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abstract = "Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sj{\"o}gren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95{\%} CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95{\%} CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95{\%} CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright {\circledC} 2010. All rights reserved.",
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Influence of STAT4 polymorphism in primary Sjögren's syndrome. / Palomino-Morales, Rogelio J.; Diaz-Gallo, Lina Marcela; Witte, Torsten; Anaya, Juan Manuel; Martín, Javier.

En: Journal of Rheumatology, 01.05.2010, p. 1016-1019.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Influence of STAT4 polymorphism in primary Sjögren's syndrome

AU - Palomino-Morales, Rogelio J.

AU - Diaz-Gallo, Lina Marcela

AU - Witte, Torsten

AU - Anaya, Juan Manuel

AU - Martín, Javier

PY - 2010/5/1

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N2 - Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95% CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright © 2010. All rights reserved.

AB - Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95% CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright © 2010. All rights reserved.

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