Resumen
Objective. To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). Methods. We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two groups of patients were constituted: in Group A (32 patients), MTX was interrupted 7 days before the surgery; in Group B (32 patients), MTX was not discontinued. Results. Fifty surgical procedures were performed in Group A and 39 procedures in Group B. No postoperative infection was observed in any group. A prolonged wound healing was noticed in 6 cases in Group A and in 4 cases in Group B (not significant). Conclusion. We suggest that the interruption of MTX is not required in patients with RA when an orthopedic surgical treatment is planned. However a large prospective study is needed to make a definitive conclusion.
Idioma original | Inglés estadounidense |
---|---|
Páginas (desde-hasta) | 1129-1132 |
Número de páginas | 4 |
Publicación | Journal of Rheumatology |
Volumen | 20 |
N.º | 7 |
Estado | Publicada - 1993 |
Publicado de forma externa | Sí |
Áreas temáticas de ASJC Scopus
- Reumatología
- Inmulogía y alergología
- Inmunología