Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Diego Garzón-Ospina; Johanna Forero-Rodríguez; Manuel A. Patarroyo

doi:10.1016/j.meegid.2015.05.001

Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Diego Garzón-Ospina
, Johanna Forero-Rodríguez
, Manuel A. Patarroyo

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

12 Citas (Scopus)

Resumen

Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	182-188
Número de páginas	7
Publicación	Infection, Genetics and Evolution
Volumen	33
DOI	https://doi.org/10.1016/j.meegid.2015.05.001
Estado	Publicada - jul. 1 2015

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Microbiología
Ecología, evolución, comportamiento y sistemática
Biología molecular
Genética
Microbiología (médica)
Enfermedades infecciosas

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10.1016/j.meegid.2015.05.001

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@article{5507ffe6a3104d39a66edee8d7b3fa2a,

title = "Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion",

abstract = "Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.",

author = "Diego Garz{\'o}n-Ospina and Johanna Forero-Rodr{\'i}guez and Patarroyo, \{Manuel A.\}",

note = "Funding Information: We would like to thank Jason Garry for translating and revising the manuscript. This work was financed by the “ Colombian Science, Technology and Innovation Department (COLCIENCIAS)” through contract RC \# 0309-2013. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.meegid.2015.05.001",

language = "English (US)",

volume = "33",

pages = "182--188",

journal = "Infection, Genetics and Evolution",

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publisher = "Elsevier BV",

}

Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion. / Garzón-Ospina, Diego; Forero-Rodríguez, Johanna; Patarroyo, Manuel A.
En: Infection, Genetics and Evolution, Vol. 33, 01.07.2015, p. 182-188.

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

TY - JOUR

T1 - Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

AU - Garzón-Ospina, Diego

AU - Forero-Rodríguez, Johanna

AU - Patarroyo, Manuel A.

N1 - Funding Information: We would like to thank Jason Garry for translating and revising the manuscript. This work was financed by the “ Colombian Science, Technology and Innovation Department (COLCIENCIAS)” through contract RC # 0309-2013. Publisher Copyright: © 2015 Elsevier B.V. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

AB - Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.

UR - https://www.scopus.com/pages/publications/84937968357

UR - https://www.scopus.com/pages/publications/84937968357#tab=citedBy

U2 - 10.1016/j.meegid.2015.05.001

DO - 10.1016/j.meegid.2015.05.001

M3 - Research Article

C2 - 25943417

AN - SCOPUS:84937968357

SN - 1567-1348

VL - 33

SP - 182

EP - 188

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

ER -

Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

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