TY - JOUR
T1 - Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion
AU - Garzón-Ospina, Diego
AU - Forero-Rodríguez, Johanna
AU - Patarroyo, Manuel A.
N1 - Funding Information:
We would like to thank Jason Garry for translating and revising the manuscript. This work was financed by the “ Colombian Science, Technology and Innovation Department (COLCIENCIAS)” through contract RC # 0309-2013.
Publisher Copyright:
© 2015 Elsevier B.V.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.
AB - Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.
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U2 - 10.1016/j.meegid.2015.05.001
DO - 10.1016/j.meegid.2015.05.001
M3 - Article
C2 - 25943417
AN - SCOPUS:84937968357
SN - 1567-1348
VL - 33
SP - 182
EP - 188
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
ER -
