Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

Diego Garzón-Ospina, Johanna Forero-Rodríguez, Manuel A. Patarroyo

Resultado de la investigación: Contribución a RevistaArtículo

7 Citas (Scopus)

Resumen

© 2015 Elsevier B.V.Detecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses.
Idioma originalEnglish (US)
Páginas (desde-hasta)182-188
Número de páginas7
PublicaciónInfection, Genetics and Evolution
DOI
EstadoPublished - jul 1 2015

Huella dactilar

Plasmodium vivax
Merozoites
merozoites
Genetic Selection
vaccine
natural selection
protein
Plasmodium
gene
antigen
immune response
population genetics
allele
parasite
Proteins
Vaccines
proteins
genome
vaccines
DNA

Citar esto

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Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion. / Garzón-Ospina, Diego; Forero-Rodríguez, Johanna; Patarroyo, Manuel A.

En: Infection, Genetics and Evolution, 01.07.2015, p. 182-188.

Resultado de la investigación: Contribución a RevistaArtículo

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T1 - Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

AU - Garzón-Ospina, Diego

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AU - Patarroyo, Manuel A.

PY - 2015/7/1

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