Programación Fetal in utero y su impacto en la salud del adulto

Robinson Ramírez-Vélez

Resultado de la investigación: Contribución a una revistaEstudio breverevisión exhaustiva

16 Citas (Scopus)

Resumen

Adverse events during intrauterine life may program organ growth and favor disease later in life. This is the usually called 'Barker's hypothesis'. Increasing evidence suggests that conditions like vascular disease, hypertension, metabolic syndrome, and type 2 diabetes mellitus are programmed during the early stages of fetal development and become manifest in late stages of life, when there is an added impact of lifestyle and other conventional acquired environmental risk factors that interact with genetic factors. The aim of this review was to provide additional, updated evidence to support the association between intrauterine fetal health and increased prevalence of chronic non-communicable diseases in adulthood. Various potential cellular and molecular mechanisms proposed to be related to the above hypothesis are discussed, including endothelial function, oxidative stress, insulin resistance, and mitochondrial function.

Título traducido de la contribuciónIn Utero Fetal Programming and Its Impact on Health in Adulthood
Idioma originalEstonio
Páginas (desde-hasta)383-393
Número de páginas11
PublicaciónEndocrinologia y Nutricion
Volumen59
N.º6
DOI
EstadoPublicada - jun 1 2012

All Science Journal Classification (ASJC) codes

  • Endocrinología, diabetes y metabolismo
  • Endocrinología

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