The purpose of this article is to present the display of the Management System of Knowledge for the Process Management of a Sterilization Center (KMOS), specifically applied in San José Hospital, located in the City of Bogotá, Colombia, including in the process, the necessary technological dimensions for its operation. Regarding the process perspective, the information system supports the management indicators process of the sterilization center. This process is a key factor for decision making, and to produce the necessary actions to reduce the percentage of health care-associated infections (HCAIs), since surveys on epidemiology have shown that approximately 5% of people using the surgical intervention services present HCAIs and, as a final outcome, they die. Regarding the technological component, main contributions are found in the implementation of the information system, using as a method, integration, the development methodology and the management methodology of service. For access to information, primary sources were used directly related to the process, through the double interview technique that is to say, a first interview producing initial information and, a second interview, confirming its declarations in the validation. Results show that automation of the management indicators allows the development, effectively and reliably, of a key process for the decision making in the sterilization center. The analysis concludes that the use of the KMOS System in the sterilization center, helps to generate pertinent information for data collection, intended to reduce the death rates, as well as health care-associated infections (HCAIs), thanks to the efficient follow up of equipment sterilization, materials, accessories and other items used in the intervention process.