TY - JOUR
T1 - Immune protection-inducing protein structures (IMPIPS) against malaria
T2 - The weapons needed for beating Odysseus
AU - Patarroyo, Manuel E.
AU - Patarroyo, Manuel A.
AU - Pabón, Laura
AU - Curtidor, Hernando
AU - Poloche, Luis A.
N1 - Funding Information:
We would like to thank Jason Garry for translating this manuscript. This research has been supported by the Colombian Science, Technology and Innovation Department (COLCIENCIAS) through contract RC # 0309-2013.
Publisher Copyright:
© 2015 Elsevier Ltd.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/12/22
Y1 - 2015/12/22
N2 - The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.
AB - The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesised vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria.
UR - http://www.scopus.com/inward/record.url?scp=84951906098&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84951906098&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2015.09.109
DO - 10.1016/j.vaccine.2015.09.109
M3 - Article
C2 - 26469723
AN - SCOPUS:84951906098
SN - 0264-410X
VL - 33
SP - 7525
EP - 7537
JO - Vaccine
JF - Vaccine
IS - 52
ER -
