IgM predominance in autoimmune disease: Genetics and gender

Carolina Duarte-Rey, Dimitrios P. Bogdanos, Patrick S C Leung, Juan Manuel Anaya, M. Eric Gershwin

Resultado de la investigación: Contribución a RevistaRevisión Literaria

31 Citas (Scopus)

Resumen

The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V.
Idioma originalEnglish (US)
PublicaciónAutoimmunity Reviews
DOI
EstadoPublished - may 1 2012

Huella dactilar

Hyper-IgM Immunodeficiency Syndrome
Autoimmune Diseases
Immunoglobulin M
Cryoglobulinemia
Autoimmune Hemolytic Anemia
Biliary Liver Cirrhosis
Immunoglobulin Isotypes
Immunoglobulin A
Multiple Sclerosis
Immunoglobulin G
Inflammation
Mutation
Genes

Citar esto

Duarte-Rey, C., Bogdanos, D. P., Leung, P. S. C., Anaya, J. M., & Gershwin, M. E. (2012). IgM predominance in autoimmune disease: Genetics and gender. Autoimmunity Reviews. https://doi.org/10.1016/j.autrev.2011.12.001
Duarte-Rey, Carolina ; Bogdanos, Dimitrios P. ; Leung, Patrick S C ; Anaya, Juan Manuel ; Gershwin, M. Eric. / IgM predominance in autoimmune disease: Genetics and gender. En: Autoimmunity Reviews. 2012.
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abstract = "The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. {\circledC} 2011 Elsevier B.V.",
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IgM predominance in autoimmune disease: Genetics and gender. / Duarte-Rey, Carolina; Bogdanos, Dimitrios P.; Leung, Patrick S C; Anaya, Juan Manuel; Gershwin, M. Eric.

En: Autoimmunity Reviews, 01.05.2012.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - IgM predominance in autoimmune disease: Genetics and gender

AU - Duarte-Rey, Carolina

AU - Bogdanos, Dimitrios P.

AU - Leung, Patrick S C

AU - Anaya, Juan Manuel

AU - Gershwin, M. Eric

PY - 2012/5/1

Y1 - 2012/5/1

N2 - The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V.

AB - The role of specific immunoglobulin isotypes in human autoimmune disease has long attracted attention. Indeed, the presence of a polyclonal gammopathy is well known in a variety of systemic autoimmune diseases and is likely the result of chronic inflammation. However, in specific clinical situations, patients manifest isolated and elevated IgM levels, but normal IgG and IgA. The pathophysiology of this elevation and the clinical significance have been elusive. However, the relationships between specific genes and hyper-IgM are now very well defined, as it has been documented in primary hyper IgM syndromes. In this review we present data on clinical diseases with characteristic IgM abnormalities, including primary and secondary hyper IgM syndromes, autoimmune hemolytic anemia, cryoglobulinemia, primary biliary cirrhosis and multiple sclerosis and place the data in the perspective of the normal maturation of the immune response, including somatic mutation and genetic rearrangement. © 2011 Elsevier B.V.

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