IgE responses to Ascaris and mite tropomyosins are risk factors for asthma

V. Ahumada, E. García, R. Dennis, M. X. Rojas, M. A. Rondón, A. Pérez, A. Peñaranda, A. M. Barragán, S. Jimenez, M. W. Kennedy, L. Caraballo

Resultado de la investigación: Contribución a RevistaArtículo

30 Citas (Scopus)

Resumen

© 2015 John Wiley & Sons Ltd.Background: The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm Ascaris or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization. Objective: To investigate the relationship between the IgE responses to Ascaris and its purified allergens and the risk of asthma in a tropical country. Methods: A nested case-control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin) and GST (glutathione transferase). In addition, specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen. Results: Sensitization to Ascaris and D. pteronyssinus was independently associated with asthma after adjustment for age, gender, socio-economic stratum, city and other IgE levels (adjusted ORs: 2.17; 95% CI 1.37-3.42 and 2.46; 95% CI 1.54-3.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross-reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aORs: 1.76; 95% CI 1.21-2.57, 1.64; 95% CI 1.14-2.35 and 1.51; 95% CI 1.02-2.24), respectively. Conclusion and Clinical Relevance: IgE responses to Ascaris are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management.
Idioma originalEnglish (US)
Páginas (desde-hasta)1189-1200
Número de páginas12
PublicaciónClinical and Experimental Allergy
DOI
EstadoPublished - ene 1 2015

Huella dactilar

Ascaris
Tropomyosin
Mites
Immunoglobulin E
Asthma
Dermatophagoides pteronyssinus
Allergens
Helminthiasis
Bystander Effect
Pyroglyphidae
Helminths
Infection
Glutathione Transferase
Case-Control Studies
Hypersensitivity
Economics
Serum
Research

Citar esto

Ahumada, V., García, E., Dennis, R., Rojas, M. X., Rondón, M. A., Pérez, A., ... Caraballo, L. (2015). IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clinical and Experimental Allergy, 1189-1200. https://doi.org/10.1111/cea.12513
Ahumada, V. ; García, E. ; Dennis, R. ; Rojas, M. X. ; Rondón, M. A. ; Pérez, A. ; Peñaranda, A. ; Barragán, A. M. ; Jimenez, S. ; Kennedy, M. W. ; Caraballo, L. / IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. En: Clinical and Experimental Allergy. 2015 ; pp. 1189-1200.
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title = "IgE responses to Ascaris and mite tropomyosins are risk factors for asthma",
abstract = "{\circledC} 2015 John Wiley & Sons Ltd.Background: The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm Ascaris or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization. Objective: To investigate the relationship between the IgE responses to Ascaris and its purified allergens and the risk of asthma in a tropical country. Methods: A nested case-control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin) and GST (glutathione transferase). In addition, specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen. Results: Sensitization to Ascaris and D. pteronyssinus was independently associated with asthma after adjustment for age, gender, socio-economic stratum, city and other IgE levels (adjusted ORs: 2.17; 95{\%} CI 1.37-3.42 and 2.46; 95{\%} CI 1.54-3.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross-reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aORs: 1.76; 95{\%} CI 1.21-2.57, 1.64; 95{\%} CI 1.14-2.35 and 1.51; 95{\%} CI 1.02-2.24), respectively. Conclusion and Clinical Relevance: IgE responses to Ascaris are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management.",
author = "V. Ahumada and E. Garc{\'i}a and R. Dennis and Rojas, {M. X.} and Rond{\'o}n, {M. A.} and A. P{\'e}rez and A. Pe{\~n}aranda and Barrag{\'a}n, {A. M.} and S. Jimenez and Kennedy, {M. W.} and L. Caraballo",
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language = "English (US)",
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Ahumada, V, García, E, Dennis, R, Rojas, MX, Rondón, MA, Pérez, A, Peñaranda, A, Barragán, AM, Jimenez, S, Kennedy, MW & Caraballo, L 2015, 'IgE responses to Ascaris and mite tropomyosins are risk factors for asthma', Clinical and Experimental Allergy, pp. 1189-1200. https://doi.org/10.1111/cea.12513

IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. / Ahumada, V.; García, E.; Dennis, R.; Rojas, M. X.; Rondón, M. A.; Pérez, A.; Peñaranda, A.; Barragán, A. M.; Jimenez, S.; Kennedy, M. W.; Caraballo, L.

En: Clinical and Experimental Allergy, 01.01.2015, p. 1189-1200.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - IgE responses to Ascaris and mite tropomyosins are risk factors for asthma

AU - Ahumada, V.

AU - García, E.

AU - Dennis, R.

AU - Rojas, M. X.

AU - Rondón, M. A.

AU - Pérez, A.

AU - Peñaranda, A.

AU - Barragán, A. M.

AU - Jimenez, S.

AU - Kennedy, M. W.

AU - Caraballo, L.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - © 2015 John Wiley & Sons Ltd.Background: The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm Ascaris or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization. Objective: To investigate the relationship between the IgE responses to Ascaris and its purified allergens and the risk of asthma in a tropical country. Methods: A nested case-control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin) and GST (glutathione transferase). In addition, specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen. Results: Sensitization to Ascaris and D. pteronyssinus was independently associated with asthma after adjustment for age, gender, socio-economic stratum, city and other IgE levels (adjusted ORs: 2.17; 95% CI 1.37-3.42 and 2.46; 95% CI 1.54-3.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross-reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aORs: 1.76; 95% CI 1.21-2.57, 1.64; 95% CI 1.14-2.35 and 1.51; 95% CI 1.02-2.24), respectively. Conclusion and Clinical Relevance: IgE responses to Ascaris are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management.

AB - © 2015 John Wiley & Sons Ltd.Background: The relationship between helminthiases and allergy is a matter of considerable interest and research. In the tropics, house dust mite exposure, a known risk factor for asthma, is frequently concurrent with helminth infections. It remains to be defined whether infection with the common roundworm Ascaris or its bystander immunological effects influence the prevalence and pathogenesis of asthma independently of mite sensitization. Objective: To investigate the relationship between the IgE responses to Ascaris and its purified allergens and the risk of asthma in a tropical country. Methods: A nested case-control study was performed in 356 subjects who reported current and past asthma symptoms (asthmatics) and 435 controls that had never experienced such symptoms. They were tested for serum levels of total IgE and specific IgE to Ascaris extract, Asc s 1 (ABA-1), Asc l 3 (tropomyosin) and GST (glutathione transferase). In addition, specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis and their tropomyosins Der p 10 and Blo t 10 was measured. Sensitization was defined as a positive specific IgE result to any extract or recombinant allergen. Results: Sensitization to Ascaris and D. pteronyssinus was independently associated with asthma after adjustment for age, gender, socio-economic stratum, city and other IgE levels (adjusted ORs: 2.17; 95% CI 1.37-3.42 and 2.46; 95% CI 1.54-3.92), respectively. There was also a significant association with sensitization to the highly allergenic and cross-reactive tropomyosins Asc l 3, Blo t 10 and Der p10 (aORs: 1.76; 95% CI 1.21-2.57, 1.64; 95% CI 1.14-2.35 and 1.51; 95% CI 1.02-2.24), respectively. Conclusion and Clinical Relevance: IgE responses to Ascaris are associated with asthma symptoms in a population living in the tropics. Sensitization to the cross-reactive Ascaris and mite tropomyosins partially underlies this finding. These results have potential relevance in asthma diagnosis and management.

U2 - 10.1111/cea.12513

DO - 10.1111/cea.12513

M3 - Article

SP - 1189

EP - 1200

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

SN - 0954-7894

ER -

Ahumada V, García E, Dennis R, Rojas MX, Rondón MA, Pérez A y otros. IgE responses to Ascaris and mite tropomyosins are risk factors for asthma. Clinical and Experimental Allergy. 2015 ene 1;1189-1200. https://doi.org/10.1111/cea.12513