Identifying and characterizing a member of the RhopH1/Clag family in Plasmodium vivax

Darwin A. Moreno-Perez, Alvaro Mongui, Laura N. Soler, Milena Sanchez-Ladino, Manuel A. Patarroyo

    Resultado de la investigación: Contribución a RevistaArtículo

    6 Citas (Scopus)

    Resumen

    Plasmodium vivax malaria caused is a public health problem that produces very high morbidity worldwide. During invasion of red blood cells the parasite requires the intervention of high molecular weight complex rhoptry proteins that are also essential for cytoadherence. PfClag9, a member of the RhopH multigene family, has been identified as being critical during Plasmodium falciparum infection. This study describes identifying and characterizing the pfclag9 ortholog in P. vivax (hereinafter named pvclag7). The pvclag7 gene is transcribed at the end of the intraerythrocytic cycle and is recognized by sera from humans who have been infected by P. vivax. PvClag7 subcellular localization has been also determined and, similar to what occurs with PfClag9, it co-localize with other proteins from the Rhoptry high molecular weight complex. © 2011 Elsevier B.V.
    Idioma originalEnglish (US)
    Páginas (desde-hasta)17-23
    Número de páginas7
    PublicaciónGene
    DOI
    EstadoPublished - jul 15 2011

    Huella dactilar

    Plasmodium vivax
    Molecular Weight
    Vivax Malaria
    Plasmodium falciparum
    Multigene Family
    Malaria
    Parasites
    Proteins
    Public Health
    Erythrocytes
    Morbidity
    Serum
    Genes

    Citar esto

    Moreno-Perez, Darwin A. ; Mongui, Alvaro ; Soler, Laura N. ; Sanchez-Ladino, Milena ; Patarroyo, Manuel A. / Identifying and characterizing a member of the RhopH1/Clag family in Plasmodium vivax. En: Gene. 2011 ; pp. 17-23.
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    abstract = "Plasmodium vivax malaria caused is a public health problem that produces very high morbidity worldwide. During invasion of red blood cells the parasite requires the intervention of high molecular weight complex rhoptry proteins that are also essential for cytoadherence. PfClag9, a member of the RhopH multigene family, has been identified as being critical during Plasmodium falciparum infection. This study describes identifying and characterizing the pfclag9 ortholog in P. vivax (hereinafter named pvclag7). The pvclag7 gene is transcribed at the end of the intraerythrocytic cycle and is recognized by sera from humans who have been infected by P. vivax. PvClag7 subcellular localization has been also determined and, similar to what occurs with PfClag9, it co-localize with other proteins from the Rhoptry high molecular weight complex. {\circledC} 2011 Elsevier B.V.",
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    Identifying and characterizing a member of the RhopH1/Clag family in Plasmodium vivax. / Moreno-Perez, Darwin A.; Mongui, Alvaro; Soler, Laura N.; Sanchez-Ladino, Milena; Patarroyo, Manuel A.

    En: Gene, 15.07.2011, p. 17-23.

    Resultado de la investigación: Contribución a RevistaArtículo

    TY - JOUR

    T1 - Identifying and characterizing a member of the RhopH1/Clag family in Plasmodium vivax

    AU - Moreno-Perez, Darwin A.

    AU - Mongui, Alvaro

    AU - Soler, Laura N.

    AU - Sanchez-Ladino, Milena

    AU - Patarroyo, Manuel A.

    PY - 2011/7/15

    Y1 - 2011/7/15

    N2 - Plasmodium vivax malaria caused is a public health problem that produces very high morbidity worldwide. During invasion of red blood cells the parasite requires the intervention of high molecular weight complex rhoptry proteins that are also essential for cytoadherence. PfClag9, a member of the RhopH multigene family, has been identified as being critical during Plasmodium falciparum infection. This study describes identifying and characterizing the pfclag9 ortholog in P. vivax (hereinafter named pvclag7). The pvclag7 gene is transcribed at the end of the intraerythrocytic cycle and is recognized by sera from humans who have been infected by P. vivax. PvClag7 subcellular localization has been also determined and, similar to what occurs with PfClag9, it co-localize with other proteins from the Rhoptry high molecular weight complex. © 2011 Elsevier B.V.

    AB - Plasmodium vivax malaria caused is a public health problem that produces very high morbidity worldwide. During invasion of red blood cells the parasite requires the intervention of high molecular weight complex rhoptry proteins that are also essential for cytoadherence. PfClag9, a member of the RhopH multigene family, has been identified as being critical during Plasmodium falciparum infection. This study describes identifying and characterizing the pfclag9 ortholog in P. vivax (hereinafter named pvclag7). The pvclag7 gene is transcribed at the end of the intraerythrocytic cycle and is recognized by sera from humans who have been infected by P. vivax. PvClag7 subcellular localization has been also determined and, similar to what occurs with PfClag9, it co-localize with other proteins from the Rhoptry high molecular weight complex. © 2011 Elsevier B.V.

    U2 - 10.1016/j.gene.2011.03.007

    DO - 10.1016/j.gene.2011.03.007

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    JO - Gene

    JF - Gene

    SN - 0378-1119

    ER -