Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

Alvaro Mongui; Oscar Perez-Leal; Jose Rojas-Caraballo; Diana I. Angel; Jimena Cortes; Manuel A. Patarroyo

doi:10.1016/j.bbrc.2007.05.015

Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

Título traducido de la contribución: Identificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivax

Alvaro Mongui
, Oscar Perez-Leal
, Jose Rojas-Caraballo
, Diana I. Angel
, Jimena Cortes
, Manuel A. Patarroyo

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

18 Citas (Scopus)

Resumen

Cuatro especies de Plasmodium causan la malaria en humanos, siendo Plasmodium falciparum la más estudiada hasta la fecha. Todas las especies de Plasmodium tienen orgánulos emparejados en forma de garrote en su extremo apical, denominados rhoptries, que contienen muchos lípidos y proteínas que se liberan durante la invasión de la célula diana. La RhopH3 de P. falciparum es una proteína rhoptry que desencadena importantes respuestas inmunitarias en pacientes de regiones endémicas. También se ha demostrado que los anticuerpos anti-RhopH3 inhiben la invasión in vitro de eritrocitos. Estudios recientes de inmunización en ratones con las proteínas homólogas RhopH3 de P. falciparum de Plasmodium yoelii y Plasmodium berghei descubrieron que son capaces de inducir protección en modelos murinos. Este estudio describe la identificación y caracterización de la proteína RhopH3 en Plasmodium vivax; está codificada por un gen de siete exones y se expresa durante la fase asexual del parásito. PvRhopH3 tiene un procesamiento similar al de su homóloga en P. falciparum y presenta un patrón de inmunolocalización celular característico de las proteínas rhoptry.

Título traducido de la contribución	Identificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivax
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	861-866
Número de páginas	6
Publicación	Biochemical and Biophysical Research Communications
Volumen	358
N.º	3
DOI	https://doi.org/10.1016/j.bbrc.2007.05.015
Estado	Publicada - jul 6 2007
Publicado de forma externa	Sí

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Inmunología

Acceder al documento

10.1016/j.bbrc.2007.05.015

Citar esto

@article{6c9925b9c19d4fe5a747a0d4c69fe066,

title = "Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue",

abstract = "Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite's asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins. {\textcopyright} 2007 Elsevier Inc. All rights reserved.",

author = "Alvaro Mongui and Oscar Perez-Leal and Jose Rojas-Caraballo and Angel, \{Diana I.\} and Jimena Cortes and Patarroyo, \{Manuel A.\}",

year = "2007",

month = jul,

day = "6",

doi = "10.1016/j.bbrc.2007.05.015",

language = "English (US)",

volume = "358",

pages = "861--866",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

AU - Mongui, Alvaro

AU - Perez-Leal, Oscar

AU - Rojas-Caraballo, Jose

AU - Angel, Diana I.

AU - Cortes, Jimena

AU - Patarroyo, Manuel A.

PY - 2007/7/6

Y1 - 2007/7/6

N2 - Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite's asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins. © 2007 Elsevier Inc. All rights reserved.

AB - Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite's asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins. © 2007 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.bbrc.2007.05.015

DO - 10.1016/j.bbrc.2007.05.015

M3 - Research Article

C2 - 17511961

SN - 0006-291X

VL - 358

SP - 861

EP - 866

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue

Resumen

ODS de las Naciones Unidas

Áreas temáticas de ASJC Scopus

Acceder al documento

Huella

Citar esto