Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

E. C. Hernández; C. F. Suárez; C. A. Parra; M. A. Patarroyo; Manuel E. Patarroyo

doi:10.1111/j.1399-0039.2005.00491.x

Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

Título traducido de la contribución: Identificación de cinco familias diferentes de genes IGHV en monos búho (Aotus nancymaae)

E. C. Hernández
, C. F. Suárez
, C. A. Parra
, M. A. Patarroyo
, Manuel E. Patarroyo

Producción científica: Contribución a revista › Artículo de Investigación › revisión exhaustiva

7 Citas (Scopus)

Resumen

Con el fin de caracterizar los genes variables de la cadena pesada de inmunoglobulinas (IGHV) en monos Aotus nancymaae, se analizaron molecularmente diferentes ARNm codificados por cinco familias de IGHV en este primate no humano, teniendo en cuenta su importancia capital en la producción de anticuerpos en una respuesta inmunitaria. Este estudio reporta productos génicos que exhiben un 91% de similitud aminoacídica con las familias IGHV1, IGHV2, IGHV3, IGHV4 e IGHV7 de IGHV humanos. Nuestros análisis sugieren que el gen IGHV tiene varias características conservadas en humanos y A. nancymaae. Varios residuos de aminoácidos que están altamente conservados en todos los miembros de la familia descritos en humanos también estaban presentes en estas familias en A. nancymaae. La diversidad de anticuerpos en estas familias se ha mantenido igual desde la divergencia de ambas especies. Nuestro estudio sigue aportando pruebas que apoyan el uso del mono A. nancymaae como modelo animal para estudiar la respuesta de los anticuerpos.

Título traducido de la contribución	Identificación de cinco familias diferentes de genes IGHV en monos búho (Aotus nancymaae)
Idioma original	Inglés estadounidense
Páginas (desde-hasta)	640-649
Número de páginas	10
Publicación	Tissue Antigens
Volumen	66
N.º	6
DOI	https://doi.org/10.1111/j.1399-0039.2005.00491.x
Estado	Publicada - dic 1 2005

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

ODS 3: Salud y bienestar

Áreas temáticas de ASJC Scopus

Inmunología

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10.1111/j.1399-0039.2005.00491.x

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@article{630a00108c804a95a6c1fa81fd02cb19,

title = "Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)",

abstract = "In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91\% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. {\textcopyright} 2005 Blackwell Munksgaard.",

author = "Hern{\'a}ndez, \{E. C.\} and Su{\'a}rez, \{C. F.\} and Parra, \{C. A.\} and Patarroyo, \{M. A.\} and Patarroyo, \{Manuel E.\}",

year = "2005",

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doi = "10.1111/j.1399-0039.2005.00491.x",

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TY - JOUR

T1 - Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

AU - Hernández, E. C.

AU - Suárez, C. F.

AU - Parra, C. A.

AU - Patarroyo, M. A.

AU - Patarroyo, Manuel E.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. © 2005 Blackwell Munksgaard.

AB - In order to characterize immunoglobulin heavy-chain variable (IGHV) genes in Aotus nancymaae monkeys, different mRNAs encoded by five IGHV families in this non-human primate were molecularly analysed considering their paramount importance in antibody production in an immune response. This study reports gene products exhibiting 91% amino acid similarity with IGHV1, IGHV2, IGHV3, IGHV4 and IGHV7 human IGHV families. Our analyses suggest that the IGHV gene has several conserved characteristics in humans and A. nancymaae. Several amino acid residues that are highly conserved in all family members described in humans were also present in these families in A. nancymaae. Antibody diversity in these families has remained the same since divergence of both species. Our study continues to provide evidence supporting the use of A. nancymaae monkey as an animal model for studying antibody response. © 2005 Blackwell Munksgaard.

U2 - 10.1111/j.1399-0039.2005.00491.x

DO - 10.1111/j.1399-0039.2005.00491.x

M3 - Research Article

C2 - 16305680

SN - 0001-2815

VL - 66

SP - 640

EP - 649

JO - Tissue Antigens

JF - Tissue Antigens

IS - 6

ER -

Identification of five different IGHV gene families in owl monkeys (Aotus nancymaae)

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