Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis

Rafael Parra-Medina; Liliana López-Kleine; Sandra Ramírez-Clavijo; César Payán-Gómez

doi:10.1038/s41598-020-69290-7

Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis

Título traducido de la contribución: Identificación de miRNAs en cáncer de próstata temprano y tardío mediante el análisis de redes de coexpresion

Rafael Parra-Medina, Liliana López-Kleine, Sandra Ramírez-Clavijo, César Payán-Gómez

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

9 Citas (Scopus)

Resumen

La incidencia de pacientes menores de 55 años diagnosticados con Cáncer de Próstata (EO-Ca) ha aumentado durante los últimos años. El conocimiento de los aspectos biológicos del cáncer de próstata (CaP) en este grupo de pacientes sigue sin estar claro. En el presente estudio aplicamos un análisis de red de coexpresión génica ponderada de la expresión de miARNs de 24 en pacientes con EO-CaP (38-45 años) y 25 pacientes con CaP de aparición tardía (LO-CaP, 71-74 años) para discriminar los miARNs que se expresan en pacientes con EO-CaP. En total, se identificaron 69 miARN expresados diferencialmente. Específicamente, los miRNAs 26 y 14 fueron desregulados exclusivamente en pacientes jóvenes y ancianos, respectivamente, y 29 mi RNAs estaban compartidos. Identificamos 20 miARNs concentradores para la red construida en EO-PCa. Seis de estos miRNAs hub mostraron importancia pronóstica en la supervivencia general o sin recaídas. Además, dos de los miARNs hub se coexpresaron con los mARNs de genes previamente identificados como desregulados en EO-PCa y en las formas más agresivas de CaP en pacientes afroamericanos en comparación con pacientes de etnia caucásica. Estos genes están involucrados en la activación de las vías de respuesta inmune, aumento de la tasa de metástasis y mal pronóstico en pacientes con CaP. En conclusión, nuestro análisis identificó miARNs que potencialmente importantes en la patología molecular de EO-PCa. Estos genes pueden servir como biomarcadores en EO-PCa y como posibles dianas terapéuticas

Título traducido de la contribución	Identificación de miRNAs en cáncer de próstata temprano y tardío mediante el análisis de redes de coexpresion
Idioma original	Inglés estadounidense
Número de artículo	12345
Páginas (desde-hasta)	1-15
Número de páginas	15
Publicación	Scientific Reports
Volumen	10
N.º	1
DOI	https://doi.org/10.1038/s41598-020-69290-7
Estado	Publicada - jul. 23 2020

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title = "Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis",

abstract = "The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38–45 years) and 25 late-onset PCa patients (LO-PCa, 71–74 years) to identify key miRNAs in EO-PCa patients. In total, 69 differentially expressed miRNAs were identified. Specifically, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identified 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic significance in relapse‐free or overall survival. Additionally, two of the hub miRNAs were coexpressed with mRNAs of genes previously identified as deregulated in EO-PCa and in the most aggressive forms of PCa in African-American patients compared with Caucasian patients. These genes are involved in activation of immune response pathways, increased rates of metastasis and poor prognosis in PCa patients. In conclusion, our analysis identified miRNAs that are potentially important in the molecular pathology of EO-PCa. These genes may serve as biomarkers in EO-PCa and as possible therapeutic targets.",

author = "Rafael Parra-Medina and Liliana L{\'o}pez-Kleine and Sandra Ram{\'i}rez-Clavijo and C{\'e}sar Pay{\'a}n-G{\'o}mez",

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N2 - The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38–45 years) and 25 late-onset PCa patients (LO-PCa, 71–74 years) to identify key miRNAs in EO-PCa patients. In total, 69 differentially expressed miRNAs were identified. Specifically, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identified 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic significance in relapse‐free or overall survival. Additionally, two of the hub miRNAs were coexpressed with mRNAs of genes previously identified as deregulated in EO-PCa and in the most aggressive forms of PCa in African-American patients compared with Caucasian patients. These genes are involved in activation of immune response pathways, increased rates of metastasis and poor prognosis in PCa patients. In conclusion, our analysis identified miRNAs that are potentially important in the molecular pathology of EO-PCa. These genes may serve as biomarkers in EO-PCa and as possible therapeutic targets.

AB - The incidence of patients under 55 years old diagnosed with Prostate Cancer (EO-PCa) has increased during recent years. The molecular biology of PCa cancer in this group of patients remains unclear. Here, we applied weighted gene coexpression network analysis of the expression of miRNAs from 24 EO-PCa patients (38–45 years) and 25 late-onset PCa patients (LO-PCa, 71–74 years) to identify key miRNAs in EO-PCa patients. In total, 69 differentially expressed miRNAs were identified. Specifically, 26 and 14 miRNAs were exclusively deregulated in young and elderly patients, respectively, and 29 miRNAs were shared. We identified 20 hub miRNAs for the network built for EO-PCa. Six of these hub miRNAs exhibited prognostic significance in relapse‐free or overall survival. Additionally, two of the hub miRNAs were coexpressed with mRNAs of genes previously identified as deregulated in EO-PCa and in the most aggressive forms of PCa in African-American patients compared with Caucasian patients. These genes are involved in activation of immune response pathways, increased rates of metastasis and poor prognosis in PCa patients. In conclusion, our analysis identified miRNAs that are potentially important in the molecular pathology of EO-PCa. These genes may serve as biomarkers in EO-PCa and as possible therapeutic targets.

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Identification of candidate miRNAs in early-onset and late-onset prostate cancer by network analysis

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