Human polymorphism at microRNAs and microRNA target sites.

Liuqing Yang, Chunru Lin, Chunyu Jin, Joy C. Yang, Bogdan Tanasa, Wenbo Wen-Hsiung Li, Daria Merkurjev, Kenneth a. Ohgi, Jie Zhang, Christopher P. Evans, Michael G. Rosenfeld, Charles E Vejnar, Matthias Blum, Evgeny M Zdobnov, A Turchinovich, T R Samatov, a G Tonevitsky, B Burwinkel, Georg Schett, Dirk ElewautIain B McInnes, Jean-Michel Dayer, Markus F Neurath, Sachin Pundhir, Jan Gorodkin, Fabiola Olivieri, Maria R Rippo, Antonio D Procopio, Francesca Fazioli, Lukas T Jeker, Xuyu Zhou, Robert Blelloch, Jeffrey a Bluestone, Claudiane Guay, Romano Regazzi, Roopali Gandhi, Brian Healy, Taha Gholipour, Svetlana Egorova, Alexander Musallam, Mohammad Shuja Hussain, Parham Nejad, Bonny Patel, Hillary Hei, Samia Khoury, Francisco Quintana, Pia Kivisakk, Tanuja Chitnis, Howard L Weiner, Yun Deng, Jian Zhao, Daisuke Sakurai, Kenneth M. Kaufman, Jeffrey C. Edberg, Robert P. Kimberly, Diane L. Kamen, Gary S. Gilkeson, Chaim O. Jacob, R. Hal Scofield, Carl D. Langefeld, Jennifer A. Kelly, Rosalind Ramsey-Goldman, Michelle A. Petri, John D. Reveille, Luis M. Vilá, Graciela S. Alarcón, Timothy J. Vyse, Bernardo A Pons-Estel, Barry I. Freedman, Patrick M. Gaffney, Kathy Moser Sivils, Judith A. James, Peter K Gregersen, Juan-Manuel Anaya, Timothy B. Niewold, Joan T. Merrill, Lindsey A. Criswell, Anne M. Stevens, Susan A. Boackle, Rita M. Cantor, Weiling Chen, Jeniffer M Grossman, Bevra H. Hahn, John B. Harley, Marta E Alarcόn-Riquelme, Elizabeth E. Brown, Betty P. Tsao, Susan Carpenter, Maninjay Atianand, Daniel Aiello, Emiliano P Ricci, Pallavi Gandhi, Lisa L Hall, Meg Byron, Brian Monks, Meabh Henry-Bezy, Jeanne B Lawrence, Luke a J O'Neill, Melissa J Moore, Daniel R Caffrey, Katherine a Fitzgerald, Dan-Xia Zhu, Lei Fan, Rui-Nan Lu, Cheng Fang, Wen-Yi Shen, Zhi-Jian Zou, Yin-Hua Wang, Hua-Yuan Zhu, Kou-Rong Miao, Peng Liu, Wei Xu, Jian-Yong Li, Jing Gong, Yin Tong, Hong-Mei Zhang, Kai Wang, Tao Hu, Ge Shan, Jun Sun, An-Yuan Guo, V Davalos, C Moutinho, A Villanueva, R Boque, Pedro Silva, F Carneiro, M Esteller, R Stephanie Huang, Eric R Gamazon, Dana Ziliak, Yujia Wen, Hae Kyung Im, Wei Zhang, Claudia Wing, Shiwei Duan, Wasim K Bleibel, Nancy J Cox, M Eileen Dolan, Patrick Brest, Pierre Lapaquette, Mouloud Souidi, Kevin Lebrigand, Annabelle Cesaro, Valérie Vouret-Craviari, Bernard Mari, Pascal Barbry, Jean-François Mosnier, Xavier Hébuterne, Annick Harel-Bellan, Baharia Mograbi, Arlette Darfeuille-Michaud, Paul Hofman, Jonathan Marchini, Bryan Howie, Lucia a Hindorff, Praveen Sethupathy, Heather a Junkins, Erin M Ramos, Jayashri P Mehta, Francis S Collins, Teri a Manolio, William Cookson, Liming Liang, Gonçalo R. Abecasis, Miriam Moffatt, Mark Lathrop, Matthew a Saunders, Han Liang

Resultado de la investigación: Contribución a RevistaArtículo

225 Citas (Scopus)

Resumen

Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific "by-products" of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.
Idioma originalEnglish (US)
Páginas (desde-hasta)2062-74
Número de páginas13
PublicaciónFrontiers in Genetics
Volumen4
N.º3
DOI
EstadoPublished - ene 1 2013

Huella dactilar

MicroRNAs
Biomarkers
Anti-Inflammatory Agents
Cell Aging
Type 2 Diabetes Mellitus
Rheumatoid Arthritis
Alzheimer Disease
Cell Death
Cardiovascular Diseases
Communication
Inflammation
Research
Neoplasms

Citar esto

Yang, L., Lin, C., Jin, C., Yang, J. C., Tanasa, B., Li, W. W-H., ... Liang, H. (2013). Human polymorphism at microRNAs and microRNA target sites. Frontiers in Genetics, 4(3), 2062-74. https://doi.org/10.1038/ng.940
Yang, Liuqing ; Lin, Chunru ; Jin, Chunyu ; Yang, Joy C. ; Tanasa, Bogdan ; Li, Wenbo Wen-Hsiung ; Merkurjev, Daria ; Ohgi, Kenneth a. ; Zhang, Jie ; Evans, Christopher P. ; Rosenfeld, Michael G. ; Vejnar, Charles E ; Blum, Matthias ; Zdobnov, Evgeny M ; Turchinovich, A ; Samatov, T R ; Tonevitsky, a G ; Burwinkel, B ; Schett, Georg ; Elewaut, Dirk ; McInnes, Iain B ; Dayer, Jean-Michel ; Neurath, Markus F ; Pundhir, Sachin ; Gorodkin, Jan ; Olivieri, Fabiola ; Rippo, Maria R ; Procopio, Antonio D ; Fazioli, Francesca ; Jeker, Lukas T ; Zhou, Xuyu ; Blelloch, Robert ; Bluestone, Jeffrey a ; Guay, Claudiane ; Regazzi, Romano ; Gandhi, Roopali ; Healy, Brian ; Gholipour, Taha ; Egorova, Svetlana ; Musallam, Alexander ; Hussain, Mohammad Shuja ; Nejad, Parham ; Patel, Bonny ; Hei, Hillary ; Khoury, Samia ; Quintana, Francisco ; Kivisakk, Pia ; Chitnis, Tanuja ; Weiner, Howard L ; Deng, Yun ; Zhao, Jian ; Sakurai, Daisuke ; Kaufman, Kenneth M. ; Edberg, Jeffrey C. ; Kimberly, Robert P. ; Kamen, Diane L. ; Gilkeson, Gary S. ; Jacob, Chaim O. ; Scofield, R. Hal ; Langefeld, Carl D. ; Kelly, Jennifer A. ; Ramsey-Goldman, Rosalind ; Petri, Michelle A. ; Reveille, John D. ; Vilá, Luis M. ; Alarcón, Graciela S. ; Vyse, Timothy J. ; Pons-Estel, Bernardo A ; Freedman, Barry I. ; Gaffney, Patrick M. ; Sivils, Kathy Moser ; James, Judith A. ; Gregersen, Peter K ; Anaya, Juan-Manuel ; Niewold, Timothy B. ; Merrill, Joan T. ; Criswell, Lindsey A. ; Stevens, Anne M. ; Boackle, Susan A. ; Cantor, Rita M. ; Chen, Weiling ; Grossman, Jeniffer M ; Hahn, Bevra H. ; Harley, John B. ; Alarcόn-Riquelme, Marta E ; Brown, Elizabeth E. ; Tsao, Betty P. ; Carpenter, Susan ; Atianand, Maninjay ; Aiello, Daniel ; Ricci, Emiliano P ; Gandhi, Pallavi ; Hall, Lisa L ; Byron, Meg ; Monks, Brian ; Henry-Bezy, Meabh ; Lawrence, Jeanne B ; O'Neill, Luke a J ; Moore, Melissa J ; Caffrey, Daniel R ; Fitzgerald, Katherine a ; Zhu, Dan-Xia ; Fan, Lei ; Lu, Rui-Nan ; Fang, Cheng ; Shen, Wen-Yi ; Zou, Zhi-Jian ; Wang, Yin-Hua ; Zhu, Hua-Yuan ; Miao, Kou-Rong ; Liu, Peng ; Xu, Wei ; Li, Jian-Yong ; Gong, Jing ; Tong, Yin ; Zhang, Hong-Mei ; Wang, Kai ; Hu, Tao ; Shan, Ge ; Sun, Jun ; Guo, An-Yuan ; Davalos, V ; Moutinho, C ; Villanueva, A ; Boque, R ; Silva, Pedro ; Carneiro, F ; Esteller, M ; Huang, R Stephanie ; Gamazon, Eric R ; Ziliak, Dana ; Wen, Yujia ; Im, Hae Kyung ; Zhang, Wei ; Wing, Claudia ; Duan, Shiwei ; Bleibel, Wasim K ; Cox, Nancy J ; Dolan, M Eileen ; Brest, Patrick ; Lapaquette, Pierre ; Souidi, Mouloud ; Lebrigand, Kevin ; Cesaro, Annabelle ; Vouret-Craviari, Valérie ; Mari, Bernard ; Barbry, Pascal ; Mosnier, Jean-François ; Hébuterne, Xavier ; Harel-Bellan, Annick ; Mograbi, Baharia ; Darfeuille-Michaud, Arlette ; Hofman, Paul ; Marchini, Jonathan ; Howie, Bryan ; Hindorff, Lucia a ; Sethupathy, Praveen ; Junkins, Heather a ; Ramos, Erin M ; Mehta, Jayashri P ; Collins, Francis S ; Manolio, Teri a ; Cookson, William ; Liang, Liming ; Abecasis, Gonçalo R. ; Moffatt, Miriam ; Lathrop, Mark ; Saunders, Matthew a ; Liang, Han. / Human polymorphism at microRNAs and microRNA target sites. En: Frontiers in Genetics. 2013 ; Vol. 4, N.º 3. pp. 2062-74.
@article{58273b8334014fa48efb1965156ce744,
title = "Human polymorphism at microRNAs and microRNA target sites.",
abstract = "Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific {"}by-products{"} of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.",
author = "Liuqing Yang and Chunru Lin and Chunyu Jin and Yang, {Joy C.} and Bogdan Tanasa and Li, {Wenbo Wen-Hsiung} and Daria Merkurjev and Ohgi, {Kenneth a.} and Jie Zhang and Evans, {Christopher P.} and Rosenfeld, {Michael G.} and Vejnar, {Charles E} and Matthias Blum and Zdobnov, {Evgeny M} and A Turchinovich and Samatov, {T R} and Tonevitsky, {a G} and B Burwinkel and Georg Schett and Dirk Elewaut and McInnes, {Iain B} and Jean-Michel Dayer and Neurath, {Markus F} and Sachin Pundhir and Jan Gorodkin and Fabiola Olivieri and Rippo, {Maria R} and Procopio, {Antonio D} and Francesca Fazioli and Jeker, {Lukas T} and Xuyu Zhou and Robert Blelloch and Bluestone, {Jeffrey a} and Claudiane Guay and Romano Regazzi and Roopali Gandhi and Brian Healy and Taha Gholipour and Svetlana Egorova and Alexander Musallam and Hussain, {Mohammad Shuja} and Parham Nejad and Bonny Patel and Hillary Hei and Samia Khoury and Francisco Quintana and Pia Kivisakk and Tanuja Chitnis and Weiner, {Howard L} and Yun Deng and Jian Zhao and Daisuke Sakurai and Kaufman, {Kenneth M.} and Edberg, {Jeffrey C.} and Kimberly, {Robert P.} and Kamen, {Diane L.} and Gilkeson, {Gary S.} and Jacob, {Chaim O.} and Scofield, {R. Hal} and Langefeld, {Carl D.} and Kelly, {Jennifer A.} and Rosalind Ramsey-Goldman and Petri, {Michelle A.} and Reveille, {John D.} and Vil{\'a}, {Luis M.} and Alarc{\'o}n, {Graciela S.} and Vyse, {Timothy J.} and Pons-Estel, {Bernardo A} and Freedman, {Barry I.} and Gaffney, {Patrick M.} and Sivils, {Kathy Moser} and James, {Judith A.} and Gregersen, {Peter K} and Juan-Manuel Anaya and Niewold, {Timothy B.} and Merrill, {Joan T.} and Criswell, {Lindsey A.} and Stevens, {Anne M.} and Boackle, {Susan A.} and Cantor, {Rita M.} and Weiling Chen and Grossman, {Jeniffer M} and Hahn, {Bevra H.} and Harley, {John B.} and Alarcόn-Riquelme, {Marta E} and Brown, {Elizabeth E.} and Tsao, {Betty P.} and Susan Carpenter and Maninjay Atianand and Daniel Aiello and Ricci, {Emiliano P} and Pallavi Gandhi and Hall, {Lisa L} and Meg Byron and Brian Monks and Meabh Henry-Bezy and Lawrence, {Jeanne B} and O'Neill, {Luke a J} and Moore, {Melissa J} and Caffrey, {Daniel R} and Fitzgerald, {Katherine a} and Dan-Xia Zhu and Lei Fan and Rui-Nan Lu and Cheng Fang and Wen-Yi Shen and Zhi-Jian Zou and Yin-Hua Wang and Hua-Yuan Zhu and Kou-Rong Miao and Peng Liu and Wei Xu and Jian-Yong Li and Jing Gong and Yin Tong and Hong-Mei Zhang and Kai Wang and Tao Hu and Ge Shan and Jun Sun and An-Yuan Guo and V Davalos and C Moutinho and A Villanueva and R Boque and Pedro Silva and F Carneiro and M Esteller and Huang, {R Stephanie} and Gamazon, {Eric R} and Dana Ziliak and Yujia Wen and Im, {Hae Kyung} and Wei Zhang and Claudia Wing and Shiwei Duan and Bleibel, {Wasim K} and Cox, {Nancy J} and Dolan, {M Eileen} and Patrick Brest and Pierre Lapaquette and Mouloud Souidi and Kevin Lebrigand and Annabelle Cesaro and Val{\'e}rie Vouret-Craviari and Bernard Mari and Pascal Barbry and Jean-Fran{\cc}ois Mosnier and Xavier H{\'e}buterne and Annick Harel-Bellan and Baharia Mograbi and Arlette Darfeuille-Michaud and Paul Hofman and Jonathan Marchini and Bryan Howie and Hindorff, {Lucia a} and Praveen Sethupathy and Junkins, {Heather a} and Ramos, {Erin M} and Mehta, {Jayashri P} and Collins, {Francis S} and Manolio, {Teri a} and William Cookson and Liming Liang and Abecasis, {Gon{\cc}alo R.} and Miriam Moffatt and Mark Lathrop and Saunders, {Matthew a} and Han Liang",
year = "2013",
month = "1",
day = "1",
doi = "10.1038/ng.940",
language = "English (US)",
volume = "4",
pages = "2062--74",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S. A.",
number = "3",

}

Yang, L, Lin, C, Jin, C, Yang, JC, Tanasa, B, Li, WW-H, Merkurjev, D, Ohgi, KA, Zhang, J, Evans, CP, Rosenfeld, MG, Vejnar, CE, Blum, M, Zdobnov, EM, Turchinovich, A, Samatov, TR, Tonevitsky, AG, Burwinkel, B, Schett, G, Elewaut, D, McInnes, IB, Dayer, J-M, Neurath, MF, Pundhir, S, Gorodkin, J, Olivieri, F, Rippo, MR, Procopio, AD, Fazioli, F, Jeker, LT, Zhou, X, Blelloch, R, Bluestone, JA, Guay, C, Regazzi, R, Gandhi, R, Healy, B, Gholipour, T, Egorova, S, Musallam, A, Hussain, MS, Nejad, P, Patel, B, Hei, H, Khoury, S, Quintana, F, Kivisakk, P, Chitnis, T, Weiner, HL, Deng, Y, Zhao, J, Sakurai, D, Kaufman, KM, Edberg, JC, Kimberly, RP, Kamen, DL, Gilkeson, GS, Jacob, CO, Scofield, RH, Langefeld, CD, Kelly, JA, Ramsey-Goldman, R, Petri, MA, Reveille, JD, Vilá, LM, Alarcón, GS, Vyse, TJ, Pons-Estel, BA, Freedman, BI, Gaffney, PM, Sivils, KM, James, JA, Gregersen, PK, Anaya, J-M, Niewold, TB, Merrill, JT, Criswell, LA, Stevens, AM, Boackle, SA, Cantor, RM, Chen, W, Grossman, JM, Hahn, BH, Harley, JB, Alarcόn-Riquelme, ME, Brown, EE, Tsao, BP, Carpenter, S, Atianand, M, Aiello, D, Ricci, EP, Gandhi, P, Hall, LL, Byron, M, Monks, B, Henry-Bezy, M, Lawrence, JB, O'Neill, LAJ, Moore, MJ, Caffrey, DR, Fitzgerald, KA, Zhu, D-X, Fan, L, Lu, R-N, Fang, C, Shen, W-Y, Zou, Z-J, Wang, Y-H, Zhu, H-Y, Miao, K-R, Liu, P, Xu, W, Li, J-Y, Gong, J, Tong, Y, Zhang, H-M, Wang, K, Hu, T, Shan, G, Sun, J, Guo, A-Y, Davalos, V, Moutinho, C, Villanueva, A, Boque, R, Silva, P, Carneiro, F, Esteller, M, Huang, RS, Gamazon, ER, Ziliak, D, Wen, Y, Im, HK, Zhang, W, Wing, C, Duan, S, Bleibel, WK, Cox, NJ, Dolan, ME, Brest, P, Lapaquette, P, Souidi, M, Lebrigand, K, Cesaro, A, Vouret-Craviari, V, Mari, B, Barbry, P, Mosnier, J-F, Hébuterne, X, Harel-Bellan, A, Mograbi, B, Darfeuille-Michaud, A, Hofman, P, Marchini, J, Howie, B, Hindorff, LA, Sethupathy, P, Junkins, HA, Ramos, EM, Mehta, JP, Collins, FS, Manolio, TA, Cookson, W, Liang, L, Abecasis, GR, Moffatt, M, Lathrop, M, Saunders, MA & Liang, H 2013, 'Human polymorphism at microRNAs and microRNA target sites.', Frontiers in Genetics, vol. 4, n.º 3, pp. 2062-74. https://doi.org/10.1038/ng.940

Human polymorphism at microRNAs and microRNA target sites. / Yang, Liuqing; Lin, Chunru; Jin, Chunyu; Yang, Joy C.; Tanasa, Bogdan; Li, Wenbo Wen-Hsiung; Merkurjev, Daria; Ohgi, Kenneth a.; Zhang, Jie; Evans, Christopher P.; Rosenfeld, Michael G.; Vejnar, Charles E; Blum, Matthias; Zdobnov, Evgeny M; Turchinovich, A; Samatov, T R; Tonevitsky, a G; Burwinkel, B; Schett, Georg; Elewaut, Dirk; McInnes, Iain B; Dayer, Jean-Michel; Neurath, Markus F; Pundhir, Sachin; Gorodkin, Jan; Olivieri, Fabiola; Rippo, Maria R; Procopio, Antonio D; Fazioli, Francesca; Jeker, Lukas T; Zhou, Xuyu; Blelloch, Robert; Bluestone, Jeffrey a; Guay, Claudiane; Regazzi, Romano; Gandhi, Roopali; Healy, Brian; Gholipour, Taha; Egorova, Svetlana; Musallam, Alexander; Hussain, Mohammad Shuja; Nejad, Parham; Patel, Bonny; Hei, Hillary; Khoury, Samia; Quintana, Francisco; Kivisakk, Pia; Chitnis, Tanuja; Weiner, Howard L; Deng, Yun; Zhao, Jian; Sakurai, Daisuke; Kaufman, Kenneth M.; Edberg, Jeffrey C.; Kimberly, Robert P.; Kamen, Diane L.; Gilkeson, Gary S.; Jacob, Chaim O.; Scofield, R. Hal; Langefeld, Carl D.; Kelly, Jennifer A.; Ramsey-Goldman, Rosalind; Petri, Michelle A.; Reveille, John D.; Vilá, Luis M.; Alarcón, Graciela S.; Vyse, Timothy J.; Pons-Estel, Bernardo A; Freedman, Barry I.; Gaffney, Patrick M.; Sivils, Kathy Moser; James, Judith A.; Gregersen, Peter K; Anaya, Juan-Manuel; Niewold, Timothy B.; Merrill, Joan T.; Criswell, Lindsey A.; Stevens, Anne M.; Boackle, Susan A.; Cantor, Rita M.; Chen, Weiling; Grossman, Jeniffer M; Hahn, Bevra H.; Harley, John B.; Alarcόn-Riquelme, Marta E; Brown, Elizabeth E.; Tsao, Betty P.; Carpenter, Susan; Atianand, Maninjay; Aiello, Daniel; Ricci, Emiliano P; Gandhi, Pallavi; Hall, Lisa L; Byron, Meg; Monks, Brian; Henry-Bezy, Meabh; Lawrence, Jeanne B; O'Neill, Luke a J; Moore, Melissa J; Caffrey, Daniel R; Fitzgerald, Katherine a; Zhu, Dan-Xia; Fan, Lei; Lu, Rui-Nan; Fang, Cheng; Shen, Wen-Yi; Zou, Zhi-Jian; Wang, Yin-Hua; Zhu, Hua-Yuan; Miao, Kou-Rong; Liu, Peng; Xu, Wei; Li, Jian-Yong; Gong, Jing; Tong, Yin; Zhang, Hong-Mei; Wang, Kai; Hu, Tao; Shan, Ge; Sun, Jun; Guo, An-Yuan; Davalos, V; Moutinho, C; Villanueva, A; Boque, R; Silva, Pedro; Carneiro, F; Esteller, M; Huang, R Stephanie; Gamazon, Eric R; Ziliak, Dana; Wen, Yujia; Im, Hae Kyung; Zhang, Wei; Wing, Claudia; Duan, Shiwei; Bleibel, Wasim K; Cox, Nancy J; Dolan, M Eileen; Brest, Patrick; Lapaquette, Pierre; Souidi, Mouloud; Lebrigand, Kevin; Cesaro, Annabelle; Vouret-Craviari, Valérie; Mari, Bernard; Barbry, Pascal; Mosnier, Jean-François; Hébuterne, Xavier; Harel-Bellan, Annick; Mograbi, Baharia; Darfeuille-Michaud, Arlette; Hofman, Paul; Marchini, Jonathan; Howie, Bryan; Hindorff, Lucia a; Sethupathy, Praveen; Junkins, Heather a; Ramos, Erin M; Mehta, Jayashri P; Collins, Francis S; Manolio, Teri a; Cookson, William; Liang, Liming; Abecasis, Gonçalo R.; Moffatt, Miriam; Lathrop, Mark; Saunders, Matthew a; Liang, Han.

En: Frontiers in Genetics, Vol. 4, N.º 3, 01.01.2013, p. 2062-74.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Human polymorphism at microRNAs and microRNA target sites.

AU - Yang, Liuqing

AU - Lin, Chunru

AU - Jin, Chunyu

AU - Yang, Joy C.

AU - Tanasa, Bogdan

AU - Li, Wenbo Wen-Hsiung

AU - Merkurjev, Daria

AU - Ohgi, Kenneth a.

AU - Zhang, Jie

AU - Evans, Christopher P.

AU - Rosenfeld, Michael G.

AU - Vejnar, Charles E

AU - Blum, Matthias

AU - Zdobnov, Evgeny M

AU - Turchinovich, A

AU - Samatov, T R

AU - Tonevitsky, a G

AU - Burwinkel, B

AU - Schett, Georg

AU - Elewaut, Dirk

AU - McInnes, Iain B

AU - Dayer, Jean-Michel

AU - Neurath, Markus F

AU - Pundhir, Sachin

AU - Gorodkin, Jan

AU - Olivieri, Fabiola

AU - Rippo, Maria R

AU - Procopio, Antonio D

AU - Fazioli, Francesca

AU - Jeker, Lukas T

AU - Zhou, Xuyu

AU - Blelloch, Robert

AU - Bluestone, Jeffrey a

AU - Guay, Claudiane

AU - Regazzi, Romano

AU - Gandhi, Roopali

AU - Healy, Brian

AU - Gholipour, Taha

AU - Egorova, Svetlana

AU - Musallam, Alexander

AU - Hussain, Mohammad Shuja

AU - Nejad, Parham

AU - Patel, Bonny

AU - Hei, Hillary

AU - Khoury, Samia

AU - Quintana, Francisco

AU - Kivisakk, Pia

AU - Chitnis, Tanuja

AU - Weiner, Howard L

AU - Deng, Yun

AU - Zhao, Jian

AU - Sakurai, Daisuke

AU - Kaufman, Kenneth M.

AU - Edberg, Jeffrey C.

AU - Kimberly, Robert P.

AU - Kamen, Diane L.

AU - Gilkeson, Gary S.

AU - Jacob, Chaim O.

AU - Scofield, R. Hal

AU - Langefeld, Carl D.

AU - Kelly, Jennifer A.

AU - Ramsey-Goldman, Rosalind

AU - Petri, Michelle A.

AU - Reveille, John D.

AU - Vilá, Luis M.

AU - Alarcón, Graciela S.

AU - Vyse, Timothy J.

AU - Pons-Estel, Bernardo A

AU - Freedman, Barry I.

AU - Gaffney, Patrick M.

AU - Sivils, Kathy Moser

AU - James, Judith A.

AU - Gregersen, Peter K

AU - Anaya, Juan-Manuel

AU - Niewold, Timothy B.

AU - Merrill, Joan T.

AU - Criswell, Lindsey A.

AU - Stevens, Anne M.

AU - Boackle, Susan A.

AU - Cantor, Rita M.

AU - Chen, Weiling

AU - Grossman, Jeniffer M

AU - Hahn, Bevra H.

AU - Harley, John B.

AU - Alarcόn-Riquelme, Marta E

AU - Brown, Elizabeth E.

AU - Tsao, Betty P.

AU - Carpenter, Susan

AU - Atianand, Maninjay

AU - Aiello, Daniel

AU - Ricci, Emiliano P

AU - Gandhi, Pallavi

AU - Hall, Lisa L

AU - Byron, Meg

AU - Monks, Brian

AU - Henry-Bezy, Meabh

AU - Lawrence, Jeanne B

AU - O'Neill, Luke a J

AU - Moore, Melissa J

AU - Caffrey, Daniel R

AU - Fitzgerald, Katherine a

AU - Zhu, Dan-Xia

AU - Fan, Lei

AU - Lu, Rui-Nan

AU - Fang, Cheng

AU - Shen, Wen-Yi

AU - Zou, Zhi-Jian

AU - Wang, Yin-Hua

AU - Zhu, Hua-Yuan

AU - Miao, Kou-Rong

AU - Liu, Peng

AU - Xu, Wei

AU - Li, Jian-Yong

AU - Gong, Jing

AU - Tong, Yin

AU - Zhang, Hong-Mei

AU - Wang, Kai

AU - Hu, Tao

AU - Shan, Ge

AU - Sun, Jun

AU - Guo, An-Yuan

AU - Davalos, V

AU - Moutinho, C

AU - Villanueva, A

AU - Boque, R

AU - Silva, Pedro

AU - Carneiro, F

AU - Esteller, M

AU - Huang, R Stephanie

AU - Gamazon, Eric R

AU - Ziliak, Dana

AU - Wen, Yujia

AU - Im, Hae Kyung

AU - Zhang, Wei

AU - Wing, Claudia

AU - Duan, Shiwei

AU - Bleibel, Wasim K

AU - Cox, Nancy J

AU - Dolan, M Eileen

AU - Brest, Patrick

AU - Lapaquette, Pierre

AU - Souidi, Mouloud

AU - Lebrigand, Kevin

AU - Cesaro, Annabelle

AU - Vouret-Craviari, Valérie

AU - Mari, Bernard

AU - Barbry, Pascal

AU - Mosnier, Jean-François

AU - Hébuterne, Xavier

AU - Harel-Bellan, Annick

AU - Mograbi, Baharia

AU - Darfeuille-Michaud, Arlette

AU - Hofman, Paul

AU - Marchini, Jonathan

AU - Howie, Bryan

AU - Hindorff, Lucia a

AU - Sethupathy, Praveen

AU - Junkins, Heather a

AU - Ramos, Erin M

AU - Mehta, Jayashri P

AU - Collins, Francis S

AU - Manolio, Teri a

AU - Cookson, William

AU - Liang, Liming

AU - Abecasis, Gonçalo R.

AU - Moffatt, Miriam

AU - Lathrop, Mark

AU - Saunders, Matthew a

AU - Liang, Han

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific "by-products" of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.

AB - Evidence on circulating microRNAs (miRNAs) is indisputably opening a new era in systemic and tissue-specific biomarker research, highlighting new inter-cellular and inter-organ communication mechanisms. Circulating miRNAs might be active messengers eliciting a systemic response as well as non-specific "by-products" of cell activity and even of cell death; in either case they have the potential to be clinically relevant biomarkers for a number of physiopathological processes, including inflammatory responses and inflammation-related conditions. A large amount of evidence indicates that miRNAs can exert two opposite roles, activating as well as inhibiting inflammatory pathways. The inhibitory action probably relates to the need for activating anti-inflammatory mechanisms to counter potent proinflammatory signals, like the nuclear factor kappaB (NF-κB) pathway, to prevent cell and tissue destruction. MiRNA-based anti-inflammatory mechanisms may acquire a crucial role during aging, where a chronic, low-level proinflammatory status is likely sustained by the cell senescence secretome and by progressive activation of immune cells over time. This process entails age-related changes, especially in extremely old age, in those circulating miRNAs that are capable of modulating the inflammatory status (inflamma-miRs). Interestingly, a number of such circulating miRNAs seem to be promising biomarkers for the major age-related diseases that share a common chronic, low-level proinflammatory status, such as cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), Alzheimer Disease (AD), rheumatoid arthritis (RA), and cancers.

U2 - 10.1038/ng.940

DO - 10.1038/ng.940

M3 - Article

C2 - 22045659

VL - 4

SP - 2062

EP - 2074

JO - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

IS - 3

ER -

Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li WW-H y otros. Human polymorphism at microRNAs and microRNA target sites. Frontiers in Genetics. 2013 ene 1;4(3):2062-74. https://doi.org/10.1038/ng.940