Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region

Xavier Castellsagué, Kevin A. Ault, F. Xavier Bosch, Darron Brown, Jack Cuzick, Daron G. Ferris, Elmar A. Joura, Suzanne M. Garland, Anna R. Giuliano, Mauricio Hernandez-Avila, Warner Huh, Ole Erik Iversen, Susanne K. Kjaer, Joaquin Luna, Joseph Monsonego, Nubia Muñoz, Evan Myers, Jorma Paavonen, Punnee Pitisuttihum, Marc StebenCosette M. Wheeler, Gonzalo Perez, Alfred Saah, Alain Luxembourg, Heather L. Sings, Christine Velicer

Producción científica: Contribución a una revistaArtículo de Investigaciónrevisión exhaustiva

32 Citas (Scopus)

Resumen

Background
We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region

Methods
Women ages 15–26 and 24–45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus.

Results
Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (~50%) and CIN2/3 (81–85%). Types 31/33/45/52/58 accounted for 25–30% of CIN1 in Latin America and Europe, but 14–18% in North America and Asia. Types 31/33/45/52/58 accounted for 33–38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17–18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2–11% of CIN2/3.

Conclusions
The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3.
Idioma originalInglés estadounidense
Páginas (desde-hasta)61-69
Número de páginas9
PublicaciónPapillomavirus Research
Volumen2
DOI
EstadoPublicada - dic. 1 2016

Áreas temáticas de ASJC Scopus

  • Virología
  • Enfermedades infecciosas

Huella

Profundice en los temas de investigación de 'Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region'. En conjunto forman una huella única.

Citar esto