Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies

Ricardo A. Cifuentes, Adriana Rojas-Villarraga, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaArtículo

12 Citas (Scopus)

Resumen

Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. © 2011 American Society for Histocompatibility and Immunogenetics.
Idioma originalEnglish (US)
Páginas (desde-hasta)581-586
Número de páginas6
PublicaciónHuman Immunology
DOI
EstadoPublished - jul 1 2011

Huella dactilar

Latin America
HLA Antigens
Type 1 Diabetes Mellitus
Meta-Analysis
Odds Ratio
Confidence Intervals
HLA-D Antigens
Haplotypes
Population
Alleles
Ligands
Peptides

Citar esto

Cifuentes, Ricardo A. ; Rojas-Villarraga, Adriana ; Anaya, Juan Manuel. / Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies. En: Human Immunology. 2011 ; pp. 581-586.
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title = "Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies",
abstract = "Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95{\%} confidence intervals (95{\%} CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95{\%} confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95{\%} CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95{\%} CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95{\%} CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95{\%} CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95{\%} CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. {\circledC} 2011 American Society for Histocompatibility and Immunogenetics.",
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Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies. / Cifuentes, Ricardo A.; Rojas-Villarraga, Adriana; Anaya, Juan Manuel.

En: Human Immunology, 01.07.2011, p. 581-586.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Human leukocyte antigen class II and type 1 diabetes in Latin America: A combined meta-analysis of association and family-based studies

AU - Cifuentes, Ricardo A.

AU - Rojas-Villarraga, Adriana

AU - Anaya, Juan Manuel

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. © 2011 American Society for Histocompatibility and Immunogenetics.

AB - Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating the effect summary odds ratios (OR) and their 95% confidence intervals (95% CI), data up to June 2010 showed that risk associations were observed with DRB1*0301-DQA1*0501-DQB1*0201 (odds ratio [OR]: 7.51; 95% confidence interval [CI]: 3.69-15.25) and DQB1*0302 in presence of DRB1*0405 (OR: 11.64; 95% CI: 3.15-43.01) or DRB1*0401 (OR: 5.85; 95% CI: 3.07-11.14). In contrast, DRB1*0404-DQB1*0302 had a nonsignificant TID risk (OR: 2.23; 95% CI: 0.91-5.43). T1D protective associations were observed with DRB1*11-DQA1*0501-DQB1*0301 (OR: 0.24; 95% CI: 0.1-0.56) and DRB1*15-DQA1*0102-DQB1*0602 (OR: 0.35; 95% CI: 0.17-0.73). These results were similar to those observed in Caucasian and other populations, thus highlighting the primary role of class II HLA in T1D regardless of ethnicity. A DRB1*04 risk hierarchy was confirmed with the DRB1*0405 being in the top. A binding prediction analysis disclosed possible receptor-ligand interactions in the HLA-antigenic peptide complex. © 2011 American Society for Histocompatibility and Immunogenetics.

U2 - 10.1016/j.humimm.2011.03.012

DO - 10.1016/j.humimm.2011.03.012

M3 - Article

SP - 581

EP - 586

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

ER -