TY - JOUR
T1 - How does age at onset influence the outcome of autoimmune diseases?
AU - Amador-Patarroyo, Manuel J.
AU - Rodriguez-Rodriguez, Alberto
AU - Montoya-Ortiz, Gladis
PY - 2012
Y1 - 2012
N2 - The age at onset refers to the time period at which an individual experiences the first symptoms of a disease. In autoimmune diseases (ADs), these symptoms can be subtle but are very relevant for diagnosis. They can appear during childhood, adulthood or late in life and may vary depending on the age at onset. Variables like mortality and morbidity and the role of genes will be reviewed with a focus on the major autoimmune disorders, namely, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes mellitus (T1D), Sjögren's syndrome, and autoimmune thyroiditis (AITD). Early age at onset is a worst prognostic factor for some ADs (i.e., SLE and T1D), while for others it does not have a significant influence on the course of disease (i.e., SS) or no unanimous consensus exists (i.e., RA and MS).
AB - The age at onset refers to the time period at which an individual experiences the first symptoms of a disease. In autoimmune diseases (ADs), these symptoms can be subtle but are very relevant for diagnosis. They can appear during childhood, adulthood or late in life and may vary depending on the age at onset. Variables like mortality and morbidity and the role of genes will be reviewed with a focus on the major autoimmune disorders, namely, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes mellitus (T1D), Sjögren's syndrome, and autoimmune thyroiditis (AITD). Early age at onset is a worst prognostic factor for some ADs (i.e., SLE and T1D), while for others it does not have a significant influence on the course of disease (i.e., SS) or no unanimous consensus exists (i.e., RA and MS).
UR - http://www.scopus.com/inward/record.url?scp=84864312014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864312014&partnerID=8YFLogxK
U2 - 10.1155/2012/251730
DO - 10.1155/2012/251730
M3 - Review article
AN - SCOPUS:84864312014
SN - 2090-0422
VL - 1
JO - Autoimmune Diseases
JF - Autoimmune Diseases
IS - 1
M1 - 251730
ER -