HLA-Class II in Latin American patients with type 1 diabetes

Adriana Rojas-Villarraga, Diana Botello-Corzo, Juan Manuel Anaya

Resultado de la investigación: Contribución a RevistaRevisión Literaria

22 Citas (Scopus)

Resumen

Objective: To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis. Methods: A systematic review of the literature searching for all HLA-Class II alleles and susceptibility for T1D case-control studies performed in LA was made up to October 2009. Effect summary ORs and 95% CI were obtained by means of the random effect model. A prediction model that identifies peptides binding to HLA-DR alleles that were significantly associated with T1D throughout the meta-analysis was done. Results: 21 studies were included (1138 cases and 1920 controls). DRB1*0301 (OR: 9.65; 95% CI: 5.69-16.36; p<0.0001), DRB1*1201 (OR: 4.84; 95% CI: 1.97-11.91; p= 0.001), DQB1*0302 (OR: 4.58; 95% CI: 3.36-6.26; p<0.0001), DQA1*0301(OR: 3.02; 95% CI: 1.37-6.65; p= 0.0059) and DQB1*0602 (OR: 0.19; 95% CI: 0.11-0.33; p<0.0001), DRB1*14 (OR: 0.18; 95% CI: 0.06-0.55; p= 0.0024), and DQB1*0501 (OR: 0.47; 95% CI: 0.26-0.83; p= 0.0097) were the most significant alleles associated with T1D. DRB1*0301-DQA1*0501-DQB1*0201 (OR: 13.50; 95% CI: 3.85-47.28; p<0.0001) and DRB1*1301-DQB1*0603 (OR: 0.25; 95% CI: 0.1-0.65; p= 0.004) were the most significant risk and protective haplotypes associated, respectively. There were peptides binding to significantly HLA-DRB1 alleles and haplotypes found through the meta-analysis from islet cell protein tyrosine phosphatase and glutamic acid decarboxylase. Conclusions: These results strengthen the effect of HLA-Class II on T1D in LA similar to Caucasians regardless of the latitudinal gradient and admixture. The shared chemical characteristics in critical pockets could explain the predisposition to present a "diabetogenic peptide" to T cells in this population. © 2010 Elsevier B.V.
Idioma originalEnglish (US)
Páginas (desde-hasta)666-673
Número de páginas8
PublicaciónAutoimmunity Reviews
DOI
EstadoPublished - ago 1 2010

Huella dactilar

Type 1 Diabetes Mellitus
Latin America
Alleles
Meta-Analysis
Haplotypes
Peptide T
HLA-DRB1 Chains
Peptides
Protein Tyrosine Phosphatases
Glutamate Decarboxylase
HLA-DR Antigens
Islets of Langerhans
Case-Control Studies
T-Lymphocytes
Population

Citar esto

Rojas-Villarraga, Adriana ; Botello-Corzo, Diana ; Anaya, Juan Manuel. / HLA-Class II in Latin American patients with type 1 diabetes. En: Autoimmunity Reviews. 2010 ; pp. 666-673.
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title = "HLA-Class II in Latin American patients with type 1 diabetes",
abstract = "Objective: To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis. Methods: A systematic review of the literature searching for all HLA-Class II alleles and susceptibility for T1D case-control studies performed in LA was made up to October 2009. Effect summary ORs and 95{\%} CI were obtained by means of the random effect model. A prediction model that identifies peptides binding to HLA-DR alleles that were significantly associated with T1D throughout the meta-analysis was done. Results: 21 studies were included (1138 cases and 1920 controls). DRB1*0301 (OR: 9.65; 95{\%} CI: 5.69-16.36; p<0.0001), DRB1*1201 (OR: 4.84; 95{\%} CI: 1.97-11.91; p= 0.001), DQB1*0302 (OR: 4.58; 95{\%} CI: 3.36-6.26; p<0.0001), DQA1*0301(OR: 3.02; 95{\%} CI: 1.37-6.65; p= 0.0059) and DQB1*0602 (OR: 0.19; 95{\%} CI: 0.11-0.33; p<0.0001), DRB1*14 (OR: 0.18; 95{\%} CI: 0.06-0.55; p= 0.0024), and DQB1*0501 (OR: 0.47; 95{\%} CI: 0.26-0.83; p= 0.0097) were the most significant alleles associated with T1D. DRB1*0301-DQA1*0501-DQB1*0201 (OR: 13.50; 95{\%} CI: 3.85-47.28; p<0.0001) and DRB1*1301-DQB1*0603 (OR: 0.25; 95{\%} CI: 0.1-0.65; p= 0.004) were the most significant risk and protective haplotypes associated, respectively. There were peptides binding to significantly HLA-DRB1 alleles and haplotypes found through the meta-analysis from islet cell protein tyrosine phosphatase and glutamic acid decarboxylase. Conclusions: These results strengthen the effect of HLA-Class II on T1D in LA similar to Caucasians regardless of the latitudinal gradient and admixture. The shared chemical characteristics in critical pockets could explain the predisposition to present a {"}diabetogenic peptide{"} to T cells in this population. {\circledC} 2010 Elsevier B.V.",
author = "Adriana Rojas-Villarraga and Diana Botello-Corzo and Anaya, {Juan Manuel}",
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HLA-Class II in Latin American patients with type 1 diabetes. / Rojas-Villarraga, Adriana; Botello-Corzo, Diana; Anaya, Juan Manuel.

En: Autoimmunity Reviews, 01.08.2010, p. 666-673.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - HLA-Class II in Latin American patients with type 1 diabetes

AU - Rojas-Villarraga, Adriana

AU - Botello-Corzo, Diana

AU - Anaya, Juan Manuel

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Objective: To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis. Methods: A systematic review of the literature searching for all HLA-Class II alleles and susceptibility for T1D case-control studies performed in LA was made up to October 2009. Effect summary ORs and 95% CI were obtained by means of the random effect model. A prediction model that identifies peptides binding to HLA-DR alleles that were significantly associated with T1D throughout the meta-analysis was done. Results: 21 studies were included (1138 cases and 1920 controls). DRB1*0301 (OR: 9.65; 95% CI: 5.69-16.36; p<0.0001), DRB1*1201 (OR: 4.84; 95% CI: 1.97-11.91; p= 0.001), DQB1*0302 (OR: 4.58; 95% CI: 3.36-6.26; p<0.0001), DQA1*0301(OR: 3.02; 95% CI: 1.37-6.65; p= 0.0059) and DQB1*0602 (OR: 0.19; 95% CI: 0.11-0.33; p<0.0001), DRB1*14 (OR: 0.18; 95% CI: 0.06-0.55; p= 0.0024), and DQB1*0501 (OR: 0.47; 95% CI: 0.26-0.83; p= 0.0097) were the most significant alleles associated with T1D. DRB1*0301-DQA1*0501-DQB1*0201 (OR: 13.50; 95% CI: 3.85-47.28; p<0.0001) and DRB1*1301-DQB1*0603 (OR: 0.25; 95% CI: 0.1-0.65; p= 0.004) were the most significant risk and protective haplotypes associated, respectively. There were peptides binding to significantly HLA-DRB1 alleles and haplotypes found through the meta-analysis from islet cell protein tyrosine phosphatase and glutamic acid decarboxylase. Conclusions: These results strengthen the effect of HLA-Class II on T1D in LA similar to Caucasians regardless of the latitudinal gradient and admixture. The shared chemical characteristics in critical pockets could explain the predisposition to present a "diabetogenic peptide" to T cells in this population. © 2010 Elsevier B.V.

AB - Objective: To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis. Methods: A systematic review of the literature searching for all HLA-Class II alleles and susceptibility for T1D case-control studies performed in LA was made up to October 2009. Effect summary ORs and 95% CI were obtained by means of the random effect model. A prediction model that identifies peptides binding to HLA-DR alleles that were significantly associated with T1D throughout the meta-analysis was done. Results: 21 studies were included (1138 cases and 1920 controls). DRB1*0301 (OR: 9.65; 95% CI: 5.69-16.36; p<0.0001), DRB1*1201 (OR: 4.84; 95% CI: 1.97-11.91; p= 0.001), DQB1*0302 (OR: 4.58; 95% CI: 3.36-6.26; p<0.0001), DQA1*0301(OR: 3.02; 95% CI: 1.37-6.65; p= 0.0059) and DQB1*0602 (OR: 0.19; 95% CI: 0.11-0.33; p<0.0001), DRB1*14 (OR: 0.18; 95% CI: 0.06-0.55; p= 0.0024), and DQB1*0501 (OR: 0.47; 95% CI: 0.26-0.83; p= 0.0097) were the most significant alleles associated with T1D. DRB1*0301-DQA1*0501-DQB1*0201 (OR: 13.50; 95% CI: 3.85-47.28; p<0.0001) and DRB1*1301-DQB1*0603 (OR: 0.25; 95% CI: 0.1-0.65; p= 0.004) were the most significant risk and protective haplotypes associated, respectively. There were peptides binding to significantly HLA-DRB1 alleles and haplotypes found through the meta-analysis from islet cell protein tyrosine phosphatase and glutamic acid decarboxylase. Conclusions: These results strengthen the effect of HLA-Class II on T1D in LA similar to Caucasians regardless of the latitudinal gradient and admixture. The shared chemical characteristics in critical pockets could explain the predisposition to present a "diabetogenic peptide" to T cells in this population. © 2010 Elsevier B.V.

U2 - 10.1016/j.autrev.2010.05.016

DO - 10.1016/j.autrev.2010.05.016

M3 - Literature review

SP - 666

EP - 673

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

ER -