HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis

Carolina Duarte-Rey, Aryce L. Pardo, Yolima Rodríguez-Velosa, Ruben D. Mantilla, Juan Manuel Anaya, Adriana Rojas-Villarraga

Resultado de la investigación: Contribución a RevistaRevisión Literaria

36 Citas (Scopus)

Resumen

Background: Autoimmune hepatitis (AIH) is a chronic liver disease to which different Human Leukocyte Antigens (HLA) have been associated, according to the ethnic/geographical group affected, age of presentation, prognosis, and serologic profile. Objective: To identify common HLA class II alleles contributing to susceptibility to AIH in Latin American population. Methods: The present study was held through a systematic review of the literature, followed by a meta-analysis of 694 cases and 1769 controls of all case-control studies that supplied enough information for odd ratio and 95% confidence interval calculation conducted to date in Latin America. Results: The serological group DQ2 was found to be risk factor for AIH, while DR5 and DQ3 were found to be protective factors in this population. At the allelic level, DQB1*02, DQB1*0603, DRB1*0405, and DRB1*1301, were found to be risk factors, while DRB1*1302 and DQB1*0301 alleles were protective factors. The physicochemical similarities and differences of critical amino acids encoding the peptide binding groove at pockets P1, P4, and P6 of these HLA molecules, elucidates their influence in the development of disease. Conclusion: The current study strengthens the HLA component of AIH in Latin America and its relationship to other populations around the world. © 2008 Elsevier B.V. All rights reserved.
Idioma originalEnglish (US)
Páginas (desde-hasta)325-331
Número de páginas7
PublicaciónAutoimmunity Reviews
DOI
EstadoPublished - feb 1 2009

Huella dactilar

Autoimmune Hepatitis
Latin America
HLA Antigens
Meta-Analysis
Alleles
Population
Ethnic Groups
Case-Control Studies
Liver Diseases
Chronic Disease
Odds Ratio
Confidence Intervals
Amino Acids
Peptides
Protective Factors

Citar esto

Duarte-Rey, C., Pardo, A. L., Rodríguez-Velosa, Y., Mantilla, R. D., Anaya, J. M., & Rojas-Villarraga, A. (2009). HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis. Autoimmunity Reviews, 325-331. https://doi.org/10.1016/j.autrev.2008.11.005
Duarte-Rey, Carolina ; Pardo, Aryce L. ; Rodríguez-Velosa, Yolima ; Mantilla, Ruben D. ; Anaya, Juan Manuel ; Rojas-Villarraga, Adriana. / HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis. En: Autoimmunity Reviews. 2009 ; pp. 325-331.
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abstract = "Background: Autoimmune hepatitis (AIH) is a chronic liver disease to which different Human Leukocyte Antigens (HLA) have been associated, according to the ethnic/geographical group affected, age of presentation, prognosis, and serologic profile. Objective: To identify common HLA class II alleles contributing to susceptibility to AIH in Latin American population. Methods: The present study was held through a systematic review of the literature, followed by a meta-analysis of 694 cases and 1769 controls of all case-control studies that supplied enough information for odd ratio and 95{\%} confidence interval calculation conducted to date in Latin America. Results: The serological group DQ2 was found to be risk factor for AIH, while DR5 and DQ3 were found to be protective factors in this population. At the allelic level, DQB1*02, DQB1*0603, DRB1*0405, and DRB1*1301, were found to be risk factors, while DRB1*1302 and DQB1*0301 alleles were protective factors. The physicochemical similarities and differences of critical amino acids encoding the peptide binding groove at pockets P1, P4, and P6 of these HLA molecules, elucidates their influence in the development of disease. Conclusion: The current study strengthens the HLA component of AIH in Latin America and its relationship to other populations around the world. {\circledC} 2008 Elsevier B.V. All rights reserved.",
author = "Carolina Duarte-Rey and Pardo, {Aryce L.} and Yolima Rodr{\'i}guez-Velosa and Mantilla, {Ruben D.} and Anaya, {Juan Manuel} and Adriana Rojas-Villarraga",
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Duarte-Rey, C, Pardo, AL, Rodríguez-Velosa, Y, Mantilla, RD, Anaya, JM & Rojas-Villarraga, A 2009, 'HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis', Autoimmunity Reviews, pp. 325-331. https://doi.org/10.1016/j.autrev.2008.11.005

HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis. / Duarte-Rey, Carolina; Pardo, Aryce L.; Rodríguez-Velosa, Yolima; Mantilla, Ruben D.; Anaya, Juan Manuel; Rojas-Villarraga, Adriana.

En: Autoimmunity Reviews, 01.02.2009, p. 325-331.

Resultado de la investigación: Contribución a RevistaRevisión Literaria

TY - JOUR

T1 - HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis

AU - Duarte-Rey, Carolina

AU - Pardo, Aryce L.

AU - Rodríguez-Velosa, Yolima

AU - Mantilla, Ruben D.

AU - Anaya, Juan Manuel

AU - Rojas-Villarraga, Adriana

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Background: Autoimmune hepatitis (AIH) is a chronic liver disease to which different Human Leukocyte Antigens (HLA) have been associated, according to the ethnic/geographical group affected, age of presentation, prognosis, and serologic profile. Objective: To identify common HLA class II alleles contributing to susceptibility to AIH in Latin American population. Methods: The present study was held through a systematic review of the literature, followed by a meta-analysis of 694 cases and 1769 controls of all case-control studies that supplied enough information for odd ratio and 95% confidence interval calculation conducted to date in Latin America. Results: The serological group DQ2 was found to be risk factor for AIH, while DR5 and DQ3 were found to be protective factors in this population. At the allelic level, DQB1*02, DQB1*0603, DRB1*0405, and DRB1*1301, were found to be risk factors, while DRB1*1302 and DQB1*0301 alleles were protective factors. The physicochemical similarities and differences of critical amino acids encoding the peptide binding groove at pockets P1, P4, and P6 of these HLA molecules, elucidates their influence in the development of disease. Conclusion: The current study strengthens the HLA component of AIH in Latin America and its relationship to other populations around the world. © 2008 Elsevier B.V. All rights reserved.

AB - Background: Autoimmune hepatitis (AIH) is a chronic liver disease to which different Human Leukocyte Antigens (HLA) have been associated, according to the ethnic/geographical group affected, age of presentation, prognosis, and serologic profile. Objective: To identify common HLA class II alleles contributing to susceptibility to AIH in Latin American population. Methods: The present study was held through a systematic review of the literature, followed by a meta-analysis of 694 cases and 1769 controls of all case-control studies that supplied enough information for odd ratio and 95% confidence interval calculation conducted to date in Latin America. Results: The serological group DQ2 was found to be risk factor for AIH, while DR5 and DQ3 were found to be protective factors in this population. At the allelic level, DQB1*02, DQB1*0603, DRB1*0405, and DRB1*1301, were found to be risk factors, while DRB1*1302 and DQB1*0301 alleles were protective factors. The physicochemical similarities and differences of critical amino acids encoding the peptide binding groove at pockets P1, P4, and P6 of these HLA molecules, elucidates their influence in the development of disease. Conclusion: The current study strengthens the HLA component of AIH in Latin America and its relationship to other populations around the world. © 2008 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.autrev.2008.11.005

DO - 10.1016/j.autrev.2008.11.005

M3 - Literature review

C2 - 19041429

SP - 325

EP - 331

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

ER -

Duarte-Rey C, Pardo AL, Rodríguez-Velosa Y, Mantilla RD, Anaya JM, Rojas-Villarraga A. HLA class II association with autoimmune hepatitis in Latin America: A meta-analysis. Autoimmunity Reviews. 2009 feb 1;325-331. https://doi.org/10.1016/j.autrev.2008.11.005