Histoplasmosis: Results of the Colombian National Survey, 1992-2008

Myrtha Arango, Elizabeth Castañeda, Clara Inés Agudelo, Catalina De Bedout, Carlos Andrés Agudelo, Angela Tobón, Melva Linares, Yorlady Valencia, Ángela Restrepo, A. Vélez, A. Zuluaga, A. L. Correa, A. M. Restrepo, B. Orozco, B. Munnnoz, C. Betancourt, C. Vélez, D. H. Cáceres, J. M. Anaya, E. JaramilloF. Díaz, G. A. Benítez, P. Cárdenas, G. A. González, G. M. Ortiz, I. C. Vélez, J. Cárdenas, J. Henao, J. Ortega, J. C. Pizano, L. Vélez, L. Franco, M. Gaviria, M. Soto, O. Uribe, P. Sierra, R. Castrillón, R. Panesso, R. Ramírez, S. Estrada, S. Jaramillo, M. I. Múnera, N. Villamarín, L. A. Castro, J. Galindo, J. Oñate, J. Vélez, C. Castañeda, M. Recalde, A. Motta, D. Palacios, M. Gutiérrez, A. Morales, M. Paláu, E. Ojeda, F. Alvarado, E. Morón, P. Castellar, I. Padilla, G. Rodríguez, C. Díaz, C. Sánchez, E. Rojas, C. Fajardo, D. I. Ríos, F. Arboleda, L. Sopó, L. G. Uribe, R. Monroy, E. Ospina, N. Torres, R. Vega, S. López, S. Valderrama, S. F. Ramírez, S. Páez, J. C. Díez, F. Berbesi, M. C. Rodríguez, J. Lizarazo, J. Pérez, M. C. Kogson, M. Rincón, J. Suárez, R. Calderón, G. Collazos, H. J. Ortega, M. I. Vargas

Resultado de la investigación: Contribución a RevistaArtículo

31 Citas (Scopus)

Resumen

Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and consequently, a survey was designed to collect histoplasmosis cases diagnosed in the country. Objective. The aim of this work was to analyze the data collected from 1992 to 2008. Materials and methods. The survey included demographic data, risk factors, clinical manifestations, imaging data, diagnostic methods and antifungal treatment. Patients were grouped according to risk factors and comparisons of the various findings were done. Results. A total of 434 surveys were gathered from 20 of the country's Departments. Most patients (96.1%) were adults, 77% were males with a mean age of 38.4 years. Only 3.9% were children less than 15 years of age. In the adult population, AIDS was reported in 70.5% of the cases; additionally, in 7.0% patients other immunosuppressive conditions were informed. The most frequent clinical manifestations were fever (76.1%), cough (54.8%) and constitutional symptoms (56.8%). X rays abnormalities were represented mainly by infiltrates (65.9%) and nodules (17.1%). Diagnosis was made by microscopic observation of H. capsulatum in 49.6% patients, by culture in 58.0% and by serological test in 14.6% cases. Antifungal use was recorded in 52.5% cases. Conclusions. Histoplasmosis is frequent in Colombia, especially in certain risk factor groups such as the HIV-infected population. Data collected from this large number of cases has allowed valid comparisons on various aspects of histoplasmosis in Colombia.
Idioma originalEnglish (US)
Páginas (desde-hasta)344-356
Número de páginas13
PublicaciónBiomedica
EstadoPublished - dic 1 2011

Huella dactilar

Histoplasmosis
Colombia
Medical imaging
Immunosuppressive Agents
Asymptomatic Infections
Serologic Tests
X rays
Diagnostic Imaging
Cough
Population
Acquired Immunodeficiency Syndrome
Fever
X-Rays
Demography
Surveys and Questionnaires
HIV

Citar esto

Arango, M., Castañeda, E., Agudelo, C. I., De Bedout, C., Agudelo, C. A., Tobón, A., ... Vargas, M. I. (2011). Histoplasmosis: Results of the Colombian National Survey, 1992-2008. Biomedica, 344-356.
Arango, Myrtha ; Castañeda, Elizabeth ; Agudelo, Clara Inés ; De Bedout, Catalina ; Agudelo, Carlos Andrés ; Tobón, Angela ; Linares, Melva ; Valencia, Yorlady ; Restrepo, Ángela ; Vélez, A. ; Zuluaga, A. ; Correa, A. L. ; Restrepo, A. M. ; Orozco, B. ; Munnnoz, B. ; Betancourt, C. ; Vélez, C. ; Cáceres, D. H. ; Anaya, J. M. ; Jaramillo, E. ; Díaz, F. ; Benítez, G. A. ; Cárdenas, P. ; González, G. A. ; Ortiz, G. M. ; Vélez, I. C. ; Cárdenas, J. ; Henao, J. ; Ortega, J. ; Pizano, J. C. ; Vélez, L. ; Franco, L. ; Gaviria, M. ; Soto, M. ; Uribe, O. ; Sierra, P. ; Castrillón, R. ; Panesso, R. ; Ramírez, R. ; Estrada, S. ; Jaramillo, S. ; Múnera, M. I. ; Villamarín, N. ; Castro, L. A. ; Galindo, J. ; Oñate, J. ; Vélez, J. ; Castañeda, C. ; Recalde, M. ; Motta, A. ; Palacios, D. ; Gutiérrez, M. ; Morales, A. ; Paláu, M. ; Ojeda, E. ; Alvarado, F. ; Morón, E. ; Castellar, P. ; Padilla, I. ; Rodríguez, G. ; Díaz, C. ; Sánchez, C. ; Rojas, E. ; Fajardo, C. ; Ríos, D. I. ; Arboleda, F. ; Sopó, L. ; Uribe, L. G. ; Monroy, R. ; Ospina, E. ; Torres, N. ; Vega, R. ; López, S. ; Valderrama, S. ; Ramírez, S. F. ; Páez, S. ; Díez, J. C. ; Berbesi, F. ; Rodríguez, M. C. ; Lizarazo, J. ; Pérez, J. ; Kogson, M. C. ; Rincón, M. ; Suárez, J. ; Calderón, R. ; Collazos, G. ; Ortega, H. J. ; Vargas, M. I. / Histoplasmosis: Results of the Colombian National Survey, 1992-2008. En: Biomedica. 2011 ; pp. 344-356.
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title = "Histoplasmosis: Results of the Colombian National Survey, 1992-2008",
abstract = "Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and consequently, a survey was designed to collect histoplasmosis cases diagnosed in the country. Objective. The aim of this work was to analyze the data collected from 1992 to 2008. Materials and methods. The survey included demographic data, risk factors, clinical manifestations, imaging data, diagnostic methods and antifungal treatment. Patients were grouped according to risk factors and comparisons of the various findings were done. Results. A total of 434 surveys were gathered from 20 of the country's Departments. Most patients (96.1{\%}) were adults, 77{\%} were males with a mean age of 38.4 years. Only 3.9{\%} were children less than 15 years of age. In the adult population, AIDS was reported in 70.5{\%} of the cases; additionally, in 7.0{\%} patients other immunosuppressive conditions were informed. The most frequent clinical manifestations were fever (76.1{\%}), cough (54.8{\%}) and constitutional symptoms (56.8{\%}). X rays abnormalities were represented mainly by infiltrates (65.9{\%}) and nodules (17.1{\%}). Diagnosis was made by microscopic observation of H. capsulatum in 49.6{\%} patients, by culture in 58.0{\%} and by serological test in 14.6{\%} cases. Antifungal use was recorded in 52.5{\%} cases. Conclusions. Histoplasmosis is frequent in Colombia, especially in certain risk factor groups such as the HIV-infected population. Data collected from this large number of cases has allowed valid comparisons on various aspects of histoplasmosis in Colombia.",
author = "Myrtha Arango and Elizabeth Casta{\~n}eda and Agudelo, {Clara In{\'e}s} and {De Bedout}, Catalina and Agudelo, {Carlos Andr{\'e}s} and Angela Tob{\'o}n and Melva Linares and Yorlady Valencia and {\'A}ngela Restrepo and A. V{\'e}lez and A. Zuluaga and Correa, {A. L.} and Restrepo, {A. M.} and B. Orozco and B. Munnnoz and C. Betancourt and C. V{\'e}lez and C{\'a}ceres, {D. H.} and Anaya, {J. M.} and E. Jaramillo and F. D{\'i}az and Ben{\'i}tez, {G. A.} and P. C{\'a}rdenas and Gonz{\'a}lez, {G. A.} and Ortiz, {G. M.} and V{\'e}lez, {I. C.} and J. C{\'a}rdenas and J. Henao and J. Ortega and Pizano, {J. C.} and L. V{\'e}lez and L. Franco and M. Gaviria and M. Soto and O. Uribe and P. Sierra and R. Castrill{\'o}n and R. Panesso and R. Ram{\'i}rez and S. Estrada and S. Jaramillo and M{\'u}nera, {M. I.} and N. Villamar{\'i}n and Castro, {L. A.} and J. Galindo and J. O{\~n}ate and J. V{\'e}lez and C. Casta{\~n}eda and M. Recalde and A. Motta and D. Palacios and M. Guti{\'e}rrez and A. Morales and M. Pal{\'a}u and E. Ojeda and F. Alvarado and E. Mor{\'o}n and P. Castellar and I. Padilla and G. Rodr{\'i}guez and C. D{\'i}az and C. S{\'a}nchez and E. Rojas and C. Fajardo and R{\'i}os, {D. I.} and F. Arboleda and L. Sop{\'o} and Uribe, {L. G.} and R. Monroy and E. Ospina and N. Torres and R. Vega and S. L{\'o}pez and S. Valderrama and Ram{\'i}rez, {S. F.} and S. P{\'a}ez and D{\'i}ez, {J. C.} and F. Berbesi and Rodr{\'i}guez, {M. C.} and J. Lizarazo and J. P{\'e}rez and Kogson, {M. C.} and M. Rinc{\'o}n and J. Su{\'a}rez and R. Calder{\'o}n and G. Collazos and Ortega, {H. J.} and Vargas, {M. I.}",
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Arango, M, Castañeda, E, Agudelo, CI, De Bedout, C, Agudelo, CA, Tobón, A, Linares, M, Valencia, Y, Restrepo, Á, Vélez, A, Zuluaga, A, Correa, AL, Restrepo, AM, Orozco, B, Munnnoz, B, Betancourt, C, Vélez, C, Cáceres, DH, Anaya, JM, Jaramillo, E, Díaz, F, Benítez, GA, Cárdenas, P, González, GA, Ortiz, GM, Vélez, IC, Cárdenas, J, Henao, J, Ortega, J, Pizano, JC, Vélez, L, Franco, L, Gaviria, M, Soto, M, Uribe, O, Sierra, P, Castrillón, R, Panesso, R, Ramírez, R, Estrada, S, Jaramillo, S, Múnera, MI, Villamarín, N, Castro, LA, Galindo, J, Oñate, J, Vélez, J, Castañeda, C, Recalde, M, Motta, A, Palacios, D, Gutiérrez, M, Morales, A, Paláu, M, Ojeda, E, Alvarado, F, Morón, E, Castellar, P, Padilla, I, Rodríguez, G, Díaz, C, Sánchez, C, Rojas, E, Fajardo, C, Ríos, DI, Arboleda, F, Sopó, L, Uribe, LG, Monroy, R, Ospina, E, Torres, N, Vega, R, López, S, Valderrama, S, Ramírez, SF, Páez, S, Díez, JC, Berbesi, F, Rodríguez, MC, Lizarazo, J, Pérez, J, Kogson, MC, Rincón, M, Suárez, J, Calderón, R, Collazos, G, Ortega, HJ & Vargas, MI 2011, 'Histoplasmosis: Results of the Colombian National Survey, 1992-2008', Biomedica, pp. 344-356.

Histoplasmosis: Results of the Colombian National Survey, 1992-2008. / Arango, Myrtha; Castañeda, Elizabeth; Agudelo, Clara Inés; De Bedout, Catalina; Agudelo, Carlos Andrés; Tobón, Angela; Linares, Melva; Valencia, Yorlady; Restrepo, Ángela; Vélez, A.; Zuluaga, A.; Correa, A. L.; Restrepo, A. M.; Orozco, B.; Munnnoz, B.; Betancourt, C.; Vélez, C.; Cáceres, D. H.; Anaya, J. M.; Jaramillo, E.; Díaz, F.; Benítez, G. A.; Cárdenas, P.; González, G. A.; Ortiz, G. M.; Vélez, I. C.; Cárdenas, J.; Henao, J.; Ortega, J.; Pizano, J. C.; Vélez, L.; Franco, L.; Gaviria, M.; Soto, M.; Uribe, O.; Sierra, P.; Castrillón, R.; Panesso, R.; Ramírez, R.; Estrada, S.; Jaramillo, S.; Múnera, M. I.; Villamarín, N.; Castro, L. A.; Galindo, J.; Oñate, J.; Vélez, J.; Castañeda, C.; Recalde, M.; Motta, A.; Palacios, D.; Gutiérrez, M.; Morales, A.; Paláu, M.; Ojeda, E.; Alvarado, F.; Morón, E.; Castellar, P.; Padilla, I.; Rodríguez, G.; Díaz, C.; Sánchez, C.; Rojas, E.; Fajardo, C.; Ríos, D. I.; Arboleda, F.; Sopó, L.; Uribe, L. G.; Monroy, R.; Ospina, E.; Torres, N.; Vega, R.; López, S.; Valderrama, S.; Ramírez, S. F.; Páez, S.; Díez, J. C.; Berbesi, F.; Rodríguez, M. C.; Lizarazo, J.; Pérez, J.; Kogson, M. C.; Rincón, M.; Suárez, J.; Calderón, R.; Collazos, G.; Ortega, H. J.; Vargas, M. I.

En: Biomedica, 01.12.2011, p. 344-356.

Resultado de la investigación: Contribución a RevistaArtículo

TY - JOUR

T1 - Histoplasmosis: Results of the Colombian National Survey, 1992-2008

AU - Arango, Myrtha

AU - Castañeda, Elizabeth

AU - Agudelo, Clara Inés

AU - De Bedout, Catalina

AU - Agudelo, Carlos Andrés

AU - Tobón, Angela

AU - Linares, Melva

AU - Valencia, Yorlady

AU - Restrepo, Ángela

AU - Vélez, A.

AU - Zuluaga, A.

AU - Correa, A. L.

AU - Restrepo, A. M.

AU - Orozco, B.

AU - Munnnoz, B.

AU - Betancourt, C.

AU - Vélez, C.

AU - Cáceres, D. H.

AU - Anaya, J. M.

AU - Jaramillo, E.

AU - Díaz, F.

AU - Benítez, G. A.

AU - Cárdenas, P.

AU - González, G. A.

AU - Ortiz, G. M.

AU - Vélez, I. C.

AU - Cárdenas, J.

AU - Henao, J.

AU - Ortega, J.

AU - Pizano, J. C.

AU - Vélez, L.

AU - Franco, L.

AU - Gaviria, M.

AU - Soto, M.

AU - Uribe, O.

AU - Sierra, P.

AU - Castrillón, R.

AU - Panesso, R.

AU - Ramírez, R.

AU - Estrada, S.

AU - Jaramillo, S.

AU - Múnera, M. I.

AU - Villamarín, N.

AU - Castro, L. A.

AU - Galindo, J.

AU - Oñate, J.

AU - Vélez, J.

AU - Castañeda, C.

AU - Recalde, M.

AU - Motta, A.

AU - Palacios, D.

AU - Gutiérrez, M.

AU - Morales, A.

AU - Paláu, M.

AU - Ojeda, E.

AU - Alvarado, F.

AU - Morón, E.

AU - Castellar, P.

AU - Padilla, I.

AU - Rodríguez, G.

AU - Díaz, C.

AU - Sánchez, C.

AU - Rojas, E.

AU - Fajardo, C.

AU - Ríos, D. I.

AU - Arboleda, F.

AU - Sopó, L.

AU - Uribe, L. G.

AU - Monroy, R.

AU - Ospina, E.

AU - Torres, N.

AU - Vega, R.

AU - López, S.

AU - Valderrama, S.

AU - Ramírez, S. F.

AU - Páez, S.

AU - Díez, J. C.

AU - Berbesi, F.

AU - Rodríguez, M. C.

AU - Lizarazo, J.

AU - Pérez, J.

AU - Kogson, M. C.

AU - Rincón, M.

AU - Suárez, J.

AU - Calderón, R.

AU - Collazos, G.

AU - Ortega, H. J.

AU - Vargas, M. I.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and consequently, a survey was designed to collect histoplasmosis cases diagnosed in the country. Objective. The aim of this work was to analyze the data collected from 1992 to 2008. Materials and methods. The survey included demographic data, risk factors, clinical manifestations, imaging data, diagnostic methods and antifungal treatment. Patients were grouped according to risk factors and comparisons of the various findings were done. Results. A total of 434 surveys were gathered from 20 of the country's Departments. Most patients (96.1%) were adults, 77% were males with a mean age of 38.4 years. Only 3.9% were children less than 15 years of age. In the adult population, AIDS was reported in 70.5% of the cases; additionally, in 7.0% patients other immunosuppressive conditions were informed. The most frequent clinical manifestations were fever (76.1%), cough (54.8%) and constitutional symptoms (56.8%). X rays abnormalities were represented mainly by infiltrates (65.9%) and nodules (17.1%). Diagnosis was made by microscopic observation of H. capsulatum in 49.6% patients, by culture in 58.0% and by serological test in 14.6% cases. Antifungal use was recorded in 52.5% cases. Conclusions. Histoplasmosis is frequent in Colombia, especially in certain risk factor groups such as the HIV-infected population. Data collected from this large number of cases has allowed valid comparisons on various aspects of histoplasmosis in Colombia.

AB - Introduction. Histoplasmosis, a fungal disorder characterized by a wide spectrum of manifestations that range from subclinical infections to disseminated processes, affects both immunocompetent and immunosuppressed individuals. Histoplasmosis is not a reportable disease in Colombia and consequently, a survey was designed to collect histoplasmosis cases diagnosed in the country. Objective. The aim of this work was to analyze the data collected from 1992 to 2008. Materials and methods. The survey included demographic data, risk factors, clinical manifestations, imaging data, diagnostic methods and antifungal treatment. Patients were grouped according to risk factors and comparisons of the various findings were done. Results. A total of 434 surveys were gathered from 20 of the country's Departments. Most patients (96.1%) were adults, 77% were males with a mean age of 38.4 years. Only 3.9% were children less than 15 years of age. In the adult population, AIDS was reported in 70.5% of the cases; additionally, in 7.0% patients other immunosuppressive conditions were informed. The most frequent clinical manifestations were fever (76.1%), cough (54.8%) and constitutional symptoms (56.8%). X rays abnormalities were represented mainly by infiltrates (65.9%) and nodules (17.1%). Diagnosis was made by microscopic observation of H. capsulatum in 49.6% patients, by culture in 58.0% and by serological test in 14.6% cases. Antifungal use was recorded in 52.5% cases. Conclusions. Histoplasmosis is frequent in Colombia, especially in certain risk factor groups such as the HIV-infected population. Data collected from this large number of cases has allowed valid comparisons on various aspects of histoplasmosis in Colombia.

M3 - Article

SP - 344

EP - 356

JO - Biomedica

JF - Biomedica

SN - 0120-4157

ER -

Arango M, Castañeda E, Agudelo CI, De Bedout C, Agudelo CA, Tobón A y otros. Histoplasmosis: Results of the Colombian National Survey, 1992-2008. Biomedica. 2011 dic 1;344-356.